rs5945988

Homo sapiens
G>A
None
Check p-value
SNV (Single Nucleotide Variation)
A=0124 (2361/18910,GnomAD)
A=0099 (372/3775,1000G)
A=0109 (403/3708,TWINSUK)
A=0109 (315/2889,ALSPAC)
chrX:114484729 (GRCh38.p7) (Xq23)
AD
GWASdb2
1   publication(s)
See rs on genome
8 Enhancers around
32 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr XNC_000023.11:g.114484729G>A
GRCh37.p13 chr X fix patch HG1462_PATCHNW_004070891.1:g.153531G>A
GRCh37.p13 chr XNC_000023.10:g.113719182G>A

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1003G=0.785A=0.215
1000GenomesAmericanSub524G=0.940A=0.060
1000GenomesEast AsianSub764G=0.990A=0.010
1000GenomesEuropeSub766G=0.890A=0.110
1000GenomesGlobalStudy-wide3775G=0.901A=0.099
1000GenomesSouth AsianSub718G=0.950A=0.050
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide2889G=0.891A=0.109
The Genome Aggregation DatabaseAfricanSub5341G=0.796A=0.204
The Genome Aggregation DatabaseAmericanSub506G=0.920A=0.080
The Genome Aggregation DatabaseEast AsianSub952G=0.990A=0.010
The Genome Aggregation DatabaseEuropeSub11936G=0.900A=0.099
The Genome Aggregation DatabaseGlobalStudy-wide18910G=0.875A=0.124
The Genome Aggregation DatabaseOtherSub175G=0.790A=0.210
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.891A=0.109
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs59459880.000986alcohol dependence20201924

eQTL of rs5945988 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs5945988 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chrX196757196969E08143226
chrX200830200907E08147299
chrX201022201357E08147491
chrX201507201629E08147976
chrX201741201941E08148210
chrX201988202042E08148457
chrX202063202376E08148532
chrX200830200907E08247299


Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chrX197753198444E06744222
chrX197753198444E06844222
chrX198527198592E06844996
chrX198686198838E06845155
chrX199716200635E06846185
chrX197753198444E06944222
chrX199716200635E06946185
chrX197753198444E07044222
chrX198527198592E07044996
chrX198686198838E07045155
chrX199652199712E07046121
chrX199716200635E07046185
chrX191581193912E07138050
chrX199716200635E07146185
chrX197753198444E07244222
chrX198527198592E07244996
chrX198686198838E07245155
chrX199716200635E07246185
chrX197753198444E07344222
chrX198527198592E07344996
chrX198686198838E07345155
chrX199652199712E07346121
chrX199716200635E07346185
chrX199716200635E07446185
chrX197753198444E08144222
chrX197753198444E08244222
chrX198527198592E08244996
chrX198686198838E08245155
chrX199010199110E08245479
chrX199303199494E08245772
chrX199652199712E08246121
chrX199716200635E08246185