rs6007413

Homo sapiens
C>G
None
Check p-value
SNV (Single Nucleotide Variation)
G=0175 (5254/29936,GnomAD)
G=0169 (4945/29114,TOPMED)
G=0225 (1128/5008,1000G)
G=0138 (533/3854,ALSPAC)
G=0133 (494/3708,TWINSUK)
chr22:45034435 (GRCh38.p7) (22q13.31)
ND
GWASdb2
1   publication(s)
See rs on genome
131 Enhancers around
29 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 22NC_000022.11:g.45034435C>G
GRCh37.p13 chr 22NC_000022.10:g.45430316C>G

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.829G=0.171
1000GenomesAmericanSub694C=0.710G=0.290
1000GenomesEast AsianSub1008C=0.671G=0.329
1000GenomesEuropeSub1006C=0.854G=0.146
1000GenomesGlobalStudy-wide5008C=0.775G=0.225
1000GenomesSouth AsianSub978C=0.780G=0.220
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.862G=0.138
The Genome Aggregation DatabaseAfricanSub8716C=0.821G=0.179
The Genome Aggregation DatabaseAmericanSub836C=0.790G=0.210
The Genome Aggregation DatabaseEast AsianSub1610C=0.649G=0.351
The Genome Aggregation DatabaseEuropeSub18474C=0.842G=0.157
The Genome Aggregation DatabaseGlobalStudy-wide29936C=0.824G=0.175
The Genome Aggregation DatabaseOtherSub300C=0.870G=0.130
Trans-Omics for Precision MedicineGlobalStudy-wide29114C=0.830G=0.169
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.867G=0.133
PMID Title Author Journal
19268276Genome-wide association study of smoking initiation and current smoking.Vink JMAm J Hum Genet

P-Value

SNP ID p-value Traits Study
rs60074134.8E-05nicotine smoking19268276

eQTL of rs6007413 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs6007413 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr224540164045401901E067-28415
chr224543176345431807E0681447
chr224543190945431990E0681593
chr224546787145468102E06837555
chr224546856345468677E06838247
chr224538841945388520E069-41796
chr224538870945388749E069-41567
chr224538882645388992E069-41324
chr224538939245389442E069-40874
chr224538957345389692E069-40624
chr224540078245400847E069-29469
chr224540086345400990E069-29326
chr224540100745401120E069-29196
chr224540133845401408E069-28908
chr224540164045401901E069-28415
chr224543176345431807E0691447
chr224543190945431990E0691593
chr224543205345432447E0691737
chr224543249745432577E0692181
chr224538939245389442E070-40874
chr224538957345389692E070-40624
chr224539054545390908E070-39408
chr224539094945391463E070-38853
chr224539148245391567E070-38749
chr224539224545392287E070-38029
chr224539233145392460E070-37856
chr224539249445392562E070-37754
chr224539312145393230E070-37086
chr224539354245393604E070-36712
chr224539385345393949E070-36367
chr224539402045394070E070-36246
chr224539409045394140E070-36176
chr224539489645394950E070-35366
chr224539525545395366E070-34950
chr224539544245395492E070-34824
chr224539552645395649E070-34667
chr224539572745395912E070-34404
chr224539593345396040E070-34276
chr224539633345396539E070-33777
chr224539778445397875E070-32441
chr224539788345397933E070-32383
chr224539810645398156E070-32160
chr224539829945398343E070-31973
chr224539851145398589E070-31727
chr224539873045398780E070-31536
chr224539883545399004E070-31312
chr224539912145399185E070-31131
chr224539951745399749E070-30567
chr224540013445400214E070-30102
chr224540025845400308E070-30008
chr224540064645400725E070-29591
chr224540072745400777E070-29539
chr224540078245400847E070-29469
chr224540086345400990E070-29326
chr224543249745432577E0702181
chr224539032245390470E071-39846
chr224539054545390908E071-39408
chr224539094945391463E071-38853
chr224539873045398780E071-31536
chr224540164045401901E071-28415
chr224543176345431807E0711447
chr224543190945431990E0711593
chr224543205345432447E0711737
chr224543249745432577E0712181
chr224539094945391463E072-38853
chr224539148245391567E072-38749
chr224540133845401408E072-28908
chr224540164045401901E072-28415
chr224543190945431990E0721593
chr224538939245389442E073-40874
chr224538957345389692E073-40624
chr224539000845390116E073-40200
chr224539148245391567E073-38749
chr224543190945431990E0731593
chr224543205345432447E0731737
chr224543249745432577E0732181
chr224539312145393230E074-37086
chr224539402045394070E074-36246
chr224539409045394140E074-36176
chr224540064645400725E074-29591
chr224540072745400777E074-29539
chr224540078245400847E074-29469
chr224540086345400990E074-29326
chr224540100745401120E074-29196
chr224540133845401408E074-28908
chr224543176345431807E0741447
chr224543190945431990E0741593
chr224539054545390908E081-39408
chr224539094945391463E081-38853
chr224539148245391567E081-38749
chr224539224545392287E081-38029
chr224539233145392460E081-37856
chr224539249445392562E081-37754
chr224539312145393230E081-37086
chr224539354245393604E081-36712
chr224539385345393949E081-36367
chr224539402045394070E081-36246
chr224539409045394140E081-36176
chr224540013445400214E081-30102
chr224540025845400308E081-30008
chr224540064645400725E081-29591
chr224540072745400777E081-29539
chr224540078245400847E081-29469
chr224540086345400990E081-29326
chr224540100745401120E081-29196
chr224540133845401408E081-28908
chr224543176345431807E0811447
chr224543190945431990E0811593
chr224547321045473448E08142894
chr224538939245389442E082-40874
chr224539000845390116E082-40200
chr224539148245391567E082-38749
chr224539224545392287E082-38029
chr224539233145392460E082-37856
chr224539249445392562E082-37754
chr224539312145393230E082-37086
chr224539354245393604E082-36712
chr224539385345393949E082-36367
chr224539402045394070E082-36246
chr224539409045394140E082-36176
chr224540013445400214E082-30102
chr224540025845400308E082-30008
chr224540064645400725E082-29591
chr224540072745400777E082-29539
chr224540078245400847E082-29469
chr224540086345400990E082-29326
chr224543190945431990E0821593
chr224543205345432447E0821737
chr224547321045473448E08242894
chr224547370445473772E08243388
chr224547377845473840E08243462










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr224540191745404636E067-25680
chr224540470545405700E067-24616
chr224540571645406863E067-23453
chr224540191745404636E068-25680
chr224540470545405700E068-24616
chr224540571645406863E068-23453
chr224540191745404636E069-25680
chr224540470545405700E069-24616
chr224540571645406863E069-23453
chr224540191745404636E070-25680
chr224540470545405700E070-24616
chr224540571645406863E070-23453
chr224540191745404636E071-25680
chr224540470545405700E071-24616
chr224540571645406863E071-23453
chr224540191745404636E072-25680
chr224540470545405700E072-24616
chr224540571645406863E072-23453
chr224540191745404636E073-25680
chr224540470545405700E073-24616
chr224540571645406863E073-23453
chr224540191745404636E074-25680
chr224540470545405700E074-24616
chr224540571645406863E074-23453
chr224540191745404636E081-25680
chr224540571645406863E081-23453
chr224540191745404636E082-25680
chr224540470545405700E082-24616
chr224540571645406863E082-23453