rs6074015

Homo sapiens
C>T
NCOA5 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
T=0316 (9472/29924,GnomAD)
T=0318 (9269/29118,TOPMED)
T=0398 (1993/5008,1000G)
T=0339 (1306/3854,ALSPAC)
T=0332 (1231/3708,TWINSUK)
chr20:46083536 (GRCh38.p7) (20q13.12)
AD
GWASdb2
1   publication(s)
See rs on genome
343 Enhancers around
28 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 20NC_000020.11:g.46083536C>T
GRCh37.p13 chr 20NC_000020.10:g.44712175C>T

Gene: NCOA5, nuclear receptor coactivator 5(minus strand)

Molecule type Change Amino acid[Codon] SO Term
NCOA5 transcript variant 1NM_020967.2:c.N/AIntron Variant
NCOA5 transcript variant X1XM_005260474.3:c.N/AIntron Variant
NCOA5 transcript variant X2XM_011528951.2:c.N/AIntron Variant
NCOA5 transcript variant X3XM_017027988.1:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.711T=0.289
1000GenomesAmericanSub694C=0.510T=0.490
1000GenomesEast AsianSub1008C=0.435T=0.565
1000GenomesEuropeSub1006C=0.653T=0.347
1000GenomesGlobalStudy-wide5008C=0.602T=0.398
1000GenomesSouth AsianSub978C=0.640T=0.360
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.661T=0.339
The Genome Aggregation DatabaseAfricanSub8704C=0.742T=0.258
The Genome Aggregation DatabaseAmericanSub838C=0.500T=0.500
The Genome Aggregation DatabaseEast AsianSub1618C=0.434T=0.566
The Genome Aggregation DatabaseEuropeSub18462C=0.686T=0.313
The Genome Aggregation DatabaseGlobalStudy-wide29924C=0.683T=0.316
The Genome Aggregation DatabaseOtherSub302C=0.650T=0.350
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.681T=0.318
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.668T=0.332
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs60740150.00027alcohol dependence(early age of onset)20201924
rs60740150.00047alcohol dependence20201924

eQTL of rs6074015 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs6074015 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr204466381444663894E067-48281
chr204466521044665274E067-46901
chr204468562744685687E067-26488
chr204468979244689906E067-22269
chr204468996744690077E067-22098
chr204469018544690349E067-21826
chr204470178244701883E067-10292
chr204470192944701979E067-10196
chr204470210344702534E067-9641
chr204470258944702767E067-9408
chr204470277244702968E067-9207
chr204470299544703155E067-9020
chr204470322944703325E067-8850
chr204470386744703917E067-8258
chr204470392244703979E067-8196
chr204470417644704249E067-7926
chr204470652544706903E067-5272
chr204470691844706968E067-5207
chr204470715944707226E067-4949
chr204470737644708140E067-4035
chr204470818744708284E067-3891
chr204470833044708404E067-3771
chr204471177644711830E067-345
chr204471189144712092E067-83
chr204471212544712220E0670
chr204471389244714228E0671717
chr204471429844714424E0672123
chr204471445544714511E0672280
chr204471487344714923E0672698
chr204471530244715352E0673127
chr204471554744715688E0673372
chr204471578344715858E0673608
chr204471592544716125E0673750
chr204471637744716573E0674202
chr204471944944719528E0677274
chr204471955844719608E0677383
chr204475768244757727E06745507
chr204466275644662912E068-49263
chr204466521044665274E068-46901
chr204468473244684820E068-27355
chr204468487644684926E068-27249
chr204468494344685004E068-27171
chr204468562744685687E068-26488
chr204468838244688504E068-23671
chr204468890344688967E068-23208
chr204468897444689052E068-23123
chr204468908144689163E068-23012
chr204468919444689515E068-22660
chr204468979244689906E068-22269
chr204468996744690077E068-22098
chr204469018544690349E068-21826
chr204469154044691618E068-20557
chr204470037844700564E068-11611
chr204470063844700722E068-11453
chr204470078444700834E068-11341
chr204470086344700913E068-11262
chr204470178244701883E068-10292
chr204470192944701979E068-10196
chr204470210344702534E068-9641
chr204470258944702767E068-9408
chr204470277244702968E068-9207
chr204470299544703155E068-9020
chr204470322944703325E068-8850
chr204470629944706394E068-5781
chr204470645844706512E068-5663
chr204470652544706903E068-5272
chr204470691844706968E068-5207
chr204470715944707226E068-4949
chr204470737644708140E068-4035
chr204470818744708284E068-3891
chr204470833044708404E068-3771
chr204471177644711830E068-345
chr204471189144712092E068-83
chr204471212544712220E0680
chr204471288844712938E068713
chr204471358444713652E0681409
chr204471389244714228E0681717
chr204471429844714424E0682123
chr204471445544714511E0682280
chr204471487344714923E0682698
chr204471530244715352E0683127
chr204471554744715688E0683372
chr204471578344715858E0683608
chr204471592544716125E0683750
chr204471637744716573E0684202
chr204475725844757464E06845083
chr204475836244758414E06846187
chr204475847244758522E06846297
chr204475877744759107E06846602
chr204476069544761942E06848520
chr204468919444689515E069-22660
chr204468979244689906E069-22269
chr204468996744690077E069-22098
chr204469018544690349E069-21826
chr204470037844700564E069-11611
chr204470063844700722E069-11453
chr204470078444700834E069-11341
chr204470086344700913E069-11262
chr204470178244701883E069-10292
chr204470192944701979E069-10196
chr204470210344702534E069-9641
chr204470258944702767E069-9408
chr204470277244702968E069-9207
chr204470299544703155E069-9020
chr204470322944703325E069-8850
chr204470386744703917E069-8258
chr204470392244703979E069-8196
chr204470417644704249E069-7926
chr204470440944704600E069-7575
chr204470629944706394E069-5781
chr204470645844706512E069-5663
chr204470652544706903E069-5272
chr204470691844706968E069-5207
chr204470715944707226E069-4949
chr204470737644708140E069-4035
chr204471177644711830E069-345
chr204471189144712092E069-83
chr204471212544712220E0690
chr204471288844712938E069713
chr204471358444713652E0691409
chr204471389244714228E0691717
chr204471429844714424E0692123
chr204471445544714511E0692280
chr204471487344714923E0692698
chr204471530244715352E0693127
chr204471554744715688E0693372
chr204471578344715858E0693608
chr204471592544716125E0693750
chr204471637744716573E0694202
chr204475768244757727E06945507
chr204475792544758020E06945750
chr204475816444758230E06945989
chr204475931344759415E06947138
chr204475942144759685E06947246
chr204466521044665274E070-46901
chr204470737644708140E070-4035
chr204471358444713652E0701409
chr204471578344715858E0703608
chr204471637744716573E0704202
chr204475725844757464E07045083
chr204468562744685687E071-26488
chr204468838244688504E071-23671
chr204468890344688967E071-23208
chr204468897444689052E071-23123
chr204468908144689163E071-23012
chr204468919444689515E071-22660
chr204468979244689906E071-22269
chr204468996744690077E071-22098
chr204469018544690349E071-21826
chr204469154044691618E071-20557
chr204470063844700722E071-11453
chr204470078444700834E071-11341
chr204470086344700913E071-11262
chr204470178244701883E071-10292
chr204470192944701979E071-10196
chr204470210344702534E071-9641
chr204470258944702767E071-9408
chr204470277244702968E071-9207
chr204470299544703155E071-9020
chr204470322944703325E071-8850
chr204470386744703917E071-8258
chr204470392244703979E071-8196
chr204470417644704249E071-7926
chr204470440944704600E071-7575
chr204470645844706512E071-5663
chr204470652544706903E071-5272
chr204470691844706968E071-5207
chr204470715944707226E071-4949
chr204470737644708140E071-4035
chr204470818744708284E071-3891
chr204470833044708404E071-3771
chr204471049644710546E071-1629
chr204471177644711830E071-345
chr204471189144712092E071-83
chr204471212544712220E0710
chr204471288844712938E071713
chr204471358444713652E0711409
chr204471389244714228E0711717
chr204471429844714424E0712123
chr204471445544714511E0712280
chr204471487344714923E0712698
chr204471530244715352E0713127
chr204471554744715688E0713372
chr204471578344715858E0713608
chr204471592544716125E0713750
chr204475931344759415E07147138
chr204476069544761942E07148520
chr204466381444663894E072-48281
chr204468838244688504E072-23671
chr204468908144689163E072-23012
chr204468919444689515E072-22660
chr204468979244689906E072-22269
chr204468996744690077E072-22098
chr204469018544690349E072-21826
chr204470063844700722E072-11453
chr204470078444700834E072-11341
chr204470086344700913E072-11262
chr204470178244701883E072-10292
chr204470192944701979E072-10196
chr204470210344702534E072-9641
chr204470258944702767E072-9408
chr204470277244702968E072-9207
chr204470299544703155E072-9020
chr204470386744703917E072-8258
chr204470392244703979E072-8196
chr204470417644704249E072-7926
chr204470440944704600E072-7575
chr204470629944706394E072-5781
chr204470645844706512E072-5663
chr204470652544706903E072-5272
chr204470691844706968E072-5207
chr204470715944707226E072-4949
chr204470737644708140E072-4035
chr204470818744708284E072-3891
chr204471177644711830E072-345
chr204471189144712092E072-83
chr204471212544712220E0720
chr204471288844712938E072713
chr204471358444713652E0721409
chr204471389244714228E0721717
chr204471429844714424E0722123
chr204471445544714511E0722280
chr204471487344714923E0722698
chr204471530244715352E0723127
chr204471554744715688E0723372
chr204471578344715858E0723608
chr204471592544716125E0723750
chr204471637744716573E0724202
chr204475725844757464E07245083
chr204466381444663894E073-48281
chr204466420044664279E073-47896
chr204466455744664607E073-47568
chr204466469144664741E073-47434
chr204466480644664885E073-47290
chr204466521044665274E073-46901
chr204468890344688967E073-23208
chr204468897444689052E073-23123
chr204468908144689163E073-23012
chr204468919444689515E073-22660
chr204468979244689906E073-22269
chr204468996744690077E073-22098
chr204469018544690349E073-21826
chr204470645844706512E073-5663
chr204470652544706903E073-5272
chr204470691844706968E073-5207
chr204470715944707226E073-4949
chr204470737644708140E073-4035
chr204470818744708284E073-3891
chr204470833044708404E073-3771
chr204471177644711830E073-345
chr204471189144712092E073-83
chr204471212544712220E0730
chr204471288844712938E073713
chr204471358444713652E0731409
chr204471389244714228E0731717
chr204471429844714424E0732123
chr204471445544714511E0732280
chr204471487344714923E0732698
chr204471530244715352E0733127
chr204471554744715688E0733372
chr204471578344715858E0733608
chr204475711644757216E07344941
chr204475725844757464E07345083
chr204475768244757727E07345507
chr204475792544758020E07345750
chr204468979244689906E074-22269
chr204468996744690077E074-22098
chr204469018544690349E074-21826
chr204470063844700722E074-11453
chr204470078444700834E074-11341
chr204470086344700913E074-11262
chr204470178244701883E074-10292
chr204470192944701979E074-10196
chr204470210344702534E074-9641
chr204470258944702767E074-9408
chr204470277244702968E074-9207
chr204470299544703155E074-9020
chr204470322944703325E074-8850
chr204470386744703917E074-8258
chr204470392244703979E074-8196
chr204470417644704249E074-7926
chr204470440944704600E074-7575
chr204470493744704998E074-7177
chr204470629944706394E074-5781
chr204470645844706512E074-5663
chr204470652544706903E074-5272
chr204470691844706968E074-5207
chr204470715944707226E074-4949
chr204470737644708140E074-4035
chr204470818744708284E074-3891
chr204470833044708404E074-3771
chr204471177644711830E074-345
chr204471189144712092E074-83
chr204471212544712220E0740
chr204471288844712938E074713
chr204471358444713652E0741409
chr204471389244714228E0741717
chr204471429844714424E0742123
chr204471445544714511E0742280
chr204471487344714923E0742698
chr204471530244715352E0743127
chr204471554744715688E0743372
chr204471578344715858E0743608
chr204468562744685687E081-26488
chr204471358444713652E0811409
chr204471389244714228E0811717
chr204471429844714424E0812123
chr204471554744715688E0813372
chr204471578344715858E0813608
chr204471592544716125E0813750
chr204471637744716573E0814202
chr204475655644756680E08144381
chr204475678444756876E08144609
chr204475689044756960E08144715
chr204475699344757067E08144818
chr204475711644757216E08144941
chr204475725844757464E08145083
chr204475768244757727E08145507
chr204475792544758020E08145750
chr204475816444758230E08145989
chr204475836244758414E08146187
chr204475847244758522E08146297
chr204475877744759107E08146602
chr204475931344759415E08147138
chr204475942144759685E08147246
chr204476069544761942E08148520
chr204466455744664607E082-47568
chr204471288844712938E082713
chr204471358444713652E0821409
chr204471389244714228E0821717
chr204471429844714424E0822123
chr204471445544714511E0822280
chr204471530244715352E0823127
chr204471554744715688E0823372
chr204475711644757216E08244941
chr204475725844757464E08245083
chr204475768244757727E08245507
chr204475792544758020E08245750
chr204475816444758230E08245989
chr204475836244758414E08246187
chr204475847244758522E08246297
chr204475931344759415E08247138
chr204475942144759685E08247246










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr204471711244719186E0674937
chr204474627444748213E06734099
chr204471711244719186E0684937
chr204472811444728753E06815939
chr204474627444748213E06834099
chr204468659344686687E069-25488
chr204471711244719186E0694937
chr204472811444728753E06915939
chr204474627444748213E06934099
chr204471711244719186E0704937
chr204468673444688209E071-23966
chr204471711244719186E0714937
chr204472811444728753E07115939
chr204474627444748213E07134099
chr204468659344686687E072-25488
chr204471711244719186E0724937
chr204472811444728753E07215939
chr204474627444748213E07234099
chr204471711244719186E0734937
chr204472811444728753E07315939
chr204474627444748213E07334099
chr204468659344686687E074-25488
chr204471711244719186E0744937
chr204472811444728753E07415939
chr204474627444748213E07434099
chr204471711244719186E0814937
chr204468659344686687E082-25488
chr204471711244719186E0824937