rs6077681

Homo sapiens
T>C
SNAP25-AS1 : Intron Variant
LOC105372524 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
C=0105 (3165/29954,GnomAD)
C=0128 (3730/29118,TOPMED)
C=0099 (496/5008,1000G)
C=0099 (381/3854,ALSPAC)
C=0087 (322/3708,TWINSUK)
chr20:10173796 (GRCh38.p7) (20p12.2)
AD
GWASdb2
1   publication(s)
See rs on genome
43 Enhancers around
84 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 20NC_000020.11:g.10173796T>C
GRCh37.p13 chr 20NC_000020.10:g.10154444T>C

Gene: SNAP25-AS1, SNAP25 antisense RNA 1(minus strand)

Molecule type Change Amino acid[Codon] SO Term
SNAP25-AS1 transcriptNR_040710.1:n.N/AIntron Variant

Gene: LOC105372524, uncharacterized LOC105372524(plus strand)

Molecule type Change Amino acid[Codon] SO Term
LOC105372524 transcript variant X1XR_001754492.1:n.N/AIntron Variant
LOC105372524 transcript variant X2XR_001754493.1:n.N/AGenic Upstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.831C=0.169
1000GenomesAmericanSub694T=0.850C=0.150
1000GenomesEast AsianSub1008T=0.974C=0.026
1000GenomesEuropeSub1006T=0.910C=0.090
1000GenomesGlobalStudy-wide5008T=0.901C=0.099
1000GenomesSouth AsianSub978T=0.950C=0.050
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.901C=0.099
The Genome Aggregation DatabaseAfricanSub8712T=0.829C=0.171
The Genome Aggregation DatabaseAmericanSub834T=0.850C=0.150
The Genome Aggregation DatabaseEast AsianSub1620T=0.972C=0.028
The Genome Aggregation DatabaseEuropeSub18486T=0.920C=0.079
The Genome Aggregation DatabaseGlobalStudy-wide29954T=0.894C=0.105
The Genome Aggregation DatabaseOtherSub302T=0.920C=0.080
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.871C=0.128
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.913C=0.087
PMID Title Author Journal
24277619ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.Quillen EEAm J Med Genet B Neuropsychiatr Genet

P-Value

SNP ID p-value Traits Study
rs60776810.000904alcohol dependence24277619

eQTL of rs6077681 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs6077681 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr201019674210196961E06742298
chr201019702010197166E06742576
chr201019718210197373E06742738
chr201019737410197482E06742930
chr201011223810112328E068-42116
chr201015218810152304E068-2140
chr201019702010197166E06842576
chr201019718210197373E06842738
chr201019737410197482E06842930
chr201011244010113448E069-40996
chr201015218810152304E069-2140
chr201019674210196961E06942298
chr201019702010197166E06942576
chr201019718210197373E06942738
chr201019737410197482E06942930
chr201011223810112328E070-42116
chr201012811910128286E070-26158
chr201019674210196961E07142298
chr201019702010197166E07142576
chr201019718210197373E07142738
chr201019737410197482E07142930
chr201015218810152304E072-2140
chr201019702010197166E07242576
chr201019718210197373E07242738
chr201019737410197482E07242930
chr201011244010113448E073-40996
chr201015218810152304E073-2140
chr201019674210196961E07342298
chr201019702010197166E07342576
chr201019718210197373E07342738
chr201019737410197482E07342930
chr201017211310172271E07417669
chr201017249510172767E07418051
chr201019737410197482E07442930
chr201011244010113448E081-40996
chr201014763810148272E081-6172
chr201014882510148877E081-5567
chr201014913210149172E081-5272
chr201011244010113448E082-40996
chr201013823310138532E082-15912
chr201014913210149172E082-5272
chr201015505810155451E082614
chr201015561310155663E0821169










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr201015257410153615E067-829
chr201015380610153890E067-554
chr201015390910154014E067-430
chr201015416710154231E067-213
chr201019779610199090E06743352
chr201019911210200908E06744668
chr201020106310201138E06746619
chr201020176110201864E06747317
chr201020212510202202E06747681
chr201020236210202425E06747918
chr201020300210203052E06748558
chr201015257410153615E068-829
chr201015380610153890E068-554
chr201015390910154014E068-430
chr201015416710154231E068-213
chr201019752810197675E06843084
chr201019779610199090E06843352
chr201019911210200908E06844668
chr201020106310201138E06846619
chr201020176110201864E06847317
chr201020212510202202E06847681
chr201020236210202425E06847918
chr201020300210203052E06848558
chr201015257410153615E069-829
chr201015380610153890E069-554
chr201015390910154014E069-430
chr201019752810197675E06943084
chr201019779610199090E06943352
chr201019911210200908E06944668
chr201020106310201138E06946619
chr201020176110201864E06947317
chr201020212510202202E06947681
chr201020236210202425E06947918
chr201020300210203052E06948558
chr201015257410153615E070-829
chr201019752810197675E07043084
chr201019779610199090E07043352
chr201019911210200908E07044668
chr201020106310201138E07046619
chr201015257410153615E071-829
chr201019752810197675E07143084
chr201019779610199090E07143352
chr201019911210200908E07144668
chr201020106310201138E07146619
chr201020176110201864E07147317
chr201020212510202202E07147681
chr201020236210202425E07147918
chr201020349210203807E07149048
chr201015257410153615E072-829
chr201015380610153890E072-554
chr201015390910154014E072-430
chr201015416710154231E072-213
chr201019752810197675E07243084
chr201019779610199090E07243352
chr201019911210200908E07244668
chr201020106310201138E07246619
chr201020176110201864E07247317
chr201020212510202202E07247681
chr201020236210202425E07247918
chr201020300210203052E07248558
chr201020349210203807E07249048
chr201015257410153615E073-829
chr201015380610153890E073-554
chr201015390910154014E073-430
chr201019779610199090E07343352
chr201019911210200908E07344668
chr201020106310201138E07346619
chr201020176110201864E07347317
chr201020212510202202E07347681
chr201020236210202425E07347918
chr201020300210203052E07348558
chr201020349210203807E07349048
chr201019779610199090E07443352
chr201019911210200908E07444668
chr201019911210200908E08144668
chr201020106310201138E08146619
chr201015257410153615E082-829
chr201019752810197675E08243084
chr201019779610199090E08243352
chr201019911210200908E08244668
chr201020106310201138E08246619
chr201020176110201864E08247317
chr201020212510202202E08247681
chr201020236210202425E08247918