rs6081761

Homo sapiens
G>A
RIN2 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
A=0402 (12016/29892,GnomAD)
A=0424 (12355/29118,TOPMED)
A=0404 (2025/5008,1000G)
A=0365 (1406/3854,ALSPAC)
A=0381 (1411/3708,TWINSUK)
chr20:19826064 (GRCh38.p7) (20p11.23)
ND
GWASdb2
1   publication(s)
See rs on genome
234 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 20NC_000020.11:g.19826064G>A
GRCh37.p13 chr 20NC_000020.10:g.19806708G>A

Gene: RIN2, Ras and Rab interactor 2(plus strand)

Molecule type Change Amino acid[Codon] SO Term
RIN2 transcript variant 1NM_001242581.1:c.N/AGenic Upstream Transcript Variant
RIN2 transcript variant 2NM_018993.3:c.N/AGenic Upstream Transcript Variant
RIN2 transcript variant X7XM_005260731.2:c.N/AIntron Variant
RIN2 transcript variant X6XM_006723574.3:c.N/AIntron Variant
RIN2 transcript variant X5XM_006723575.3:c.N/AIntron Variant
RIN2 transcript variant X2XM_017027887.1:c.N/AIntron Variant
RIN2 transcript variant X3XM_017027888.1:c.N/AIntron Variant
RIN2 transcript variant X19XM_005260733.2:c.N/AGenic Upstream Transcript Variant
RIN2 transcript variant X14XM_006723577.2:c.N/AGenic Upstream Transcript Variant
RIN2 transcript variant X1XM_011529255.2:c.N/AGenic Upstream Transcript Variant
RIN2 transcript variant X10XM_011529257.1:c.N/AGenic Upstream Transcript Variant
RIN2 transcript variant X12XM_011529258.2:c.N/AGenic Upstream Transcript Variant
RIN2 transcript variant X17XM_011529259.2:c.N/AGenic Upstream Transcript Variant
RIN2 transcript variant X4XM_017027889.1:c.N/AGenic Upstream Transcript Variant
RIN2 transcript variant X10XM_017027890.1:c.N/AGenic Upstream Transcript Variant
RIN2 transcript variant X15XM_017027891.1:c.N/AGenic Upstream Transcript Variant
RIN2 transcript variant X16XM_017027892.1:c.N/AGenic Upstream Transcript Variant
RIN2 transcript variant X18XM_017027893.1:c.N/AGenic Upstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.509A=0.491
1000GenomesAmericanSub694G=0.640A=0.360
1000GenomesEast AsianSub1008G=0.649A=0.351
1000GenomesEuropeSub1006G=0.594A=0.406
1000GenomesGlobalStudy-wide5008G=0.596A=0.404
1000GenomesSouth AsianSub978G=0.630A=0.370
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.635A=0.365
The Genome Aggregation DatabaseAfricanSub8704G=0.542A=0.458
The Genome Aggregation DatabaseAmericanSub832G=0.690A=0.310
The Genome Aggregation DatabaseEast AsianSub1618G=0.664A=0.336
The Genome Aggregation DatabaseEuropeSub18436G=0.616A=0.383
The Genome Aggregation DatabaseGlobalStudy-wide29892G=0.598A=0.402
The Genome Aggregation DatabaseOtherSub302G=0.460A=0.540
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.575A=0.424
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.619A=0.381
PMID Title Author Journal
17158188Novel genes identified in a high-density genome wide association study for nicotine dependence.Bierut LJHum Mol Genet

P-Value

SNP ID p-value Traits Study
rs60817610.000109nicotine dependence17158188

eQTL of rs6081761 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs6081761 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr201976437819766453E067-40255
chr201976655819767638E067-39070
chr201978758319788945E067-17763
chr201979454619794862E067-11846
chr201979499519795216E067-11492
chr201979531819795362E067-11346
chr201979570219795924E067-10784
chr201981449519814545E0677787
chr201981493119815004E0678223
chr201981506619815197E0678358
chr201981581119815861E0679103
chr201981587119815931E0679163
chr201981634219816839E0679634
chr201981686919816919E06710161
chr201981786819817918E06711160
chr201981795719818116E06711249
chr201981816719818227E06711459
chr201981899119819083E06712283
chr201981914619819424E06712438
chr201981966119819767E06712953
chr201981980319819951E06713095
chr201982094419821291E06714236
chr201982133819821388E06714630
chr201982979419831203E06723086
chr201983126019831311E06724552
chr201983204819832098E06725340
chr201983239219832463E06725684
chr201983250619832708E06725798
chr201983271619832849E06726008
chr201983313419833218E06726426
chr201976437819766453E068-40255
chr201976655819767638E068-39070
chr201977313719773234E068-33474
chr201977325519773305E068-33403
chr201978758319788945E068-17763
chr201979499519795216E068-11492
chr201980855519809519E0681847
chr201981358019813864E0686872
chr201981493119815004E0688223
chr201981506619815197E0688358
chr201981914619819424E06812438
chr201981966119819767E06812953
chr201981980319819951E06813095
chr201982000119820086E06813293
chr201982023019820311E06813522
chr201982052319820576E06813815
chr201982094419821291E06814236
chr201982133819821388E06814630
chr201982262219822672E06815914
chr201982979419831203E06823086
chr201983126019831311E06824552
chr201983204819832098E06825340
chr201983239219832463E06825684
chr201983250619832708E06825798
chr201983271619832849E06826008
chr201976437819766453E069-40255
chr201976655819767638E069-39070
chr201977313719773234E069-33474
chr201977325519773305E069-33403
chr201979499519795216E069-11492
chr201979606419796711E069-9997
chr201979673919796847E069-9861
chr201981493119815004E0698223
chr201981506619815197E0698358
chr201981581119815861E0699103
chr201981587119815931E0699163
chr201981634219816839E0699634
chr201981686919816919E06910161
chr201981914619819424E06912438
chr201981966119819767E06912953
chr201981980319819951E06913095
chr201982000119820086E06913293
chr201982023019820311E06913522
chr201982052319820576E06913815
chr201982094419821291E06914236
chr201982133819821388E06914630
chr201982262219822672E06915914
chr201982979419831203E06923086
chr201983126019831311E06924552
chr201983204819832098E06925340
chr201983239219832463E06925684
chr201983250619832708E06925798
chr201983271619832849E06926008
chr201983313419833218E06926426
chr201982979419831203E07023086
chr201975807019758256E071-48452
chr201975828319758438E071-48270
chr201975853419758574E071-48134
chr201976068119761313E071-45395
chr201976136019761524E071-45184
chr201976437819766453E071-40255
chr201976655819767638E071-39070
chr201977313719773234E071-33474
chr201977325519773305E071-33403
chr201978758319788945E071-17763
chr201979365919793699E071-13009
chr201979391319794042E071-12666
chr201979406019794140E071-12568
chr201979454619794862E071-11846
chr201979499519795216E071-11492
chr201979531819795362E071-11346
chr201979570219795924E071-10784
chr201980246319802527E071-4181
chr201980255219802633E071-4075
chr201980264919802699E071-4009
chr201980298419803082E071-3626
chr201980855519809519E0711847
chr201980954219809627E0712834
chr201981407419814468E0717366
chr201981449519814545E0717787
chr201981493119815004E0718223
chr201981506619815197E0718358
chr201981581119815861E0719103
chr201981587119815931E0719163
chr201981634219816839E0719634
chr201981786819817918E07111160
chr201981795719818116E07111249
chr201981914619819424E07112438
chr201981966119819767E07112953
chr201981980319819951E07113095
chr201982094419821291E07114236
chr201982133819821388E07114630
chr201982262219822672E07115914
chr201982979419831203E07123086
chr201983204819832098E07125340
chr201983239219832463E07125684
chr201983250619832708E07125798
chr201983271619832849E07126008
chr201983313419833218E07126426
chr201983866019838710E07131952
chr201983883319838916E07132125
chr201984840219849428E07141694
chr201984950819849558E07142800
chr201975873219758882E072-47826
chr201975916219759322E072-47386
chr201976068119761313E072-45395
chr201976136019761524E072-45184
chr201976168719761798E072-44910
chr201976437819766453E072-40255
chr201976655819767638E072-39070
chr201977313719773234E072-33474
chr201977325519773305E072-33403
chr201978758319788945E072-17763
chr201979281119792984E072-13724
chr201979343919793543E072-13165
chr201979365919793699E072-13009
chr201979391319794042E072-12666
chr201979406019794140E072-12568
chr201979454619794862E072-11846
chr201979499519795216E072-11492
chr201979531819795362E072-11346
chr201980246319802527E072-4181
chr201980855519809519E0721847
chr201980954219809627E0722834
chr201981493119815004E0728223
chr201981506619815197E0728358
chr201981581119815861E0729103
chr201981587119815931E0729163
chr201981686919816919E07210161
chr201981899119819083E07212283
chr201981914619819424E07212438
chr201981966119819767E07212953
chr201981980319819951E07213095
chr201982000119820086E07213293
chr201982023019820311E07213522
chr201982094419821291E07214236
chr201982262219822672E07215914
chr201982979419831203E07223086
chr201983126019831311E07224552
chr201983204819832098E07225340
chr201983239219832463E07225684
chr201983250619832708E07225798
chr201983271619832849E07226008
chr201983313419833218E07226426
chr201976437819766453E073-40255
chr201976655819767638E073-39070
chr201978758319788945E073-17763
chr201979391319794042E073-12666
chr201979406019794140E073-12568
chr201979499519795216E073-11492
chr201979531819795362E073-11346
chr201981449519814545E0737787
chr201981493119815004E0738223
chr201981506619815197E0738358
chr201982979419831203E07323086
chr201983126019831311E07324552
chr201983204819832098E07325340
chr201983239219832463E07325684
chr201983250619832708E07325798
chr201983271619832849E07326008
chr201976068119761313E074-45395
chr201976136019761524E074-45184
chr201976437819766453E074-40255
chr201976655819767638E074-39070
chr201978758319788945E074-17763
chr201979343919793543E074-13165
chr201979365919793699E074-13009
chr201979391319794042E074-12666
chr201979406019794140E074-12568
chr201979454619794862E074-11846
chr201979499519795216E074-11492
chr201979531819795362E074-11346
chr201979570219795924E074-10784
chr201979606419796711E074-9997
chr201979673919796847E074-9861
chr201979686719797077E074-9631
chr201981493119815004E0748223
chr201981506619815197E0748358
chr201981581119815861E0749103
chr201981587119815931E0749163
chr201981634219816839E0749634
chr201981966119819767E07412953
chr201981980319819951E07413095
chr201982000119820086E07413293
chr201982133819821388E07414630
chr201982979419831203E07423086
chr201983126019831311E07424552
chr201983204819832098E07425340
chr201983239219832463E07425684
chr201983250619832708E07425798
chr201983271619832849E07426008
chr201976437819766453E081-40255
chr201978916919789260E081-17448
chr201978951819789568E081-17140
chr201978967019789745E081-16963
chr201978997719790077E081-16631
chr201979011019790539E081-16169
chr201980109919801630E081-5078
chr201976437819766453E082-40255
chr201976655819767638E082-39070
chr201978758319788945E082-17763
chr201978916919789260E082-17448
chr201981634219816839E0829634
chr201981686919816919E08210161