rs61776290

Organism: Homo sapiens

Alleles: C>T

Gene : Feature

None

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

T=0085 (2572/29940,GnomAD)
T=0070 (2037/29118,TOPMED)
T=0071 (358/5008,1000G)
T=0101 (389/3854,ALSPAC)
T=0110 (407/3708,TWINSUK)

Position: chr1:10634850 (GRCh38.p7) (1p36.22)

Phenotype: AD

Dataset:

GWASdb2 | GWASCatalog

Publications: 1 publication(s)

Genomic View: See rs on genome

Enhancer: 132 Enhancers around

Promoter: 10 Promoters around

Variant Details Frequency Publications p-values eSNP meSNP

Genomic Coordinates

Sequence Name	Change(s)
GRCh38.p7 chr 1	NC_000001.11:g.10634850C>T
GRCh37.p13 chr 1	NC_000001.10:g.10694907C>T

Population Frequency

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	C=0.992	T=0.008
1000Genomes	American	Sub	694	C=0.940	T=0.060
1000Genomes	East Asian	Sub	1008	C=0.999	T=0.001
1000Genomes	Europe	Sub	1006	C=0.872	T=0.128
1000Genomes	Global	Study-wide	5008	C=0.929	T=0.071
1000Genomes	South Asian	Sub	978	C=0.820	T=0.180
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	C=0.899	T=0.101
The Genome Aggregation Database	African	Sub	8720	C=0.982	T=0.018
The Genome Aggregation Database	American	Sub	838	C=0.930	T=0.070
The Genome Aggregation Database	East Asian	Sub	1622	C=1.000	T=0.000
The Genome Aggregation Database	Europe	Sub	18458	C=0.875	T=0.124
The Genome Aggregation Database	Global	Study-wide	29940	C=0.914	T=0.085
The Genome Aggregation Database	Other	Sub	302	C=0.820	T=0.180
Trans-Omics for Precision Medicine	Global	Study-wide	29118	C=0.930	T=0.070
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	C=0.890	T=0.110

PMID	Title	Author	Journal
24962325	Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families.	Kapoor M	Drug Alcohol Depend

P-Value

SNP ID	p-value	Traits	Study
rs61776290	2E-07	alcohol dependence (age at onset)	24962325

eQTL of rs61776290 in Brain tissues (GTEx Analysis Release V7)

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

meQTL of rs61776290 in Fetal Brain

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome	Start	End	Region	Distance ( -/+ : Up/Downstream )
chr1	10674618	10674691	E067	-20216
chr1	10676080	10676130	E067	-18777
chr1	10676190	10676279	E067	-18628
chr1	10723387	10724295	E067	28480
chr1	10725989	10726476	E067	31082
chr1	10658122	10658519	E068	-36388
chr1	10674618	10674691	E068	-20216
chr1	10723387	10724295	E068	28480
chr1	10674618	10674691	E069	-20216
chr1	10676080	10676130	E069	-18777
chr1	10676190	10676279	E069	-18628
chr1	10723387	10724295	E069	28480
chr1	10725626	10725944	E069	30719
chr1	10725989	10726476	E069	31082
chr1	10657285	10657517	E070	-37390
chr1	10657636	10657777	E070	-37130
chr1	10657802	10657902	E070	-37005
chr1	10658122	10658519	E070	-36388
chr1	10658521	10658674	E070	-36233
chr1	10658819	10658900	E070	-36007
chr1	10659286	10659975	E070	-34932
chr1	10675435	10675632	E070	-19275
chr1	10676080	10676130	E070	-18777
chr1	10676190	10676279	E070	-18628
chr1	10676383	10676433	E070	-18474
chr1	10683745	10683802	E070	-11105
chr1	10692059	10692263	E070	-2644
chr1	10692491	10692700	E070	-2207
chr1	10692869	10693116	E070	-1791
chr1	10694645	10695194	E070	0
chr1	10695242	10696319	E070	335
chr1	10699890	10700675	E070	4983
chr1	10700718	10700866	E070	5811
chr1	10700912	10701033	E070	6005
chr1	10701085	10701135	E070	6178
chr1	10701359	10701479	E070	6452
chr1	10708766	10708816	E070	13859
chr1	10711529	10711737	E070	16622
chr1	10711855	10712174	E070	16948
chr1	10723007	10723313	E070	28100
chr1	10723387	10724295	E070	28480
chr1	10724441	10724697	E070	29534
chr1	10730791	10730871	E070	35884
chr1	10731201	10731514	E070	36294
chr1	10731564	10731686	E070	36657
chr1	10731720	10732119	E070	36813
chr1	10733491	10733680	E070	38584
chr1	10734074	10734134	E070	39167
chr1	10734771	10734824	E070	39864
chr1	10735138	10735403	E070	40231
chr1	10735523	10735640	E070	40616
chr1	10737231	10738061	E070	42324
chr1	10738134	10738259	E070	43227
chr1	10738329	10738466	E070	43422
chr1	10738761	10738860	E070	43854
chr1	10738967	10740291	E070	44060
chr1	10658122	10658519	E071	-36388
chr1	10658521	10658674	E071	-36233
chr1	10674173	10674224	E071	-20683
chr1	10674618	10674691	E071	-20216
chr1	10675435	10675632	E071	-19275
chr1	10676080	10676130	E071	-18777
chr1	10676190	10676279	E071	-18628
chr1	10694645	10695194	E071	0
chr1	10695242	10696319	E071	335
chr1	10700718	10700866	E071	5811
chr1	10700912	10701033	E071	6005
chr1	10701085	10701135	E071	6178
chr1	10723007	10723313	E071	28100
chr1	10723387	10724295	E071	28480
chr1	10725626	10725944	E071	30719
chr1	10725989	10726476	E071	31082
chr1	10742209	10742367	E071	47302
chr1	10658122	10658519	E072	-36388
chr1	10674618	10674691	E072	-20216
chr1	10676080	10676130	E072	-18777
chr1	10676190	10676279	E072	-18628
chr1	10723007	10723313	E072	28100
chr1	10723387	10724295	E072	28480
chr1	10724441	10724697	E072	29534
chr1	10725626	10725944	E072	30719
chr1	10725989	10726476	E072	31082
chr1	10658122	10658519	E073	-36388
chr1	10694645	10695194	E073	0
chr1	10723007	10723313	E073	28100
chr1	10723387	10724295	E073	28480
chr1	10658122	10658519	E074	-36388
chr1	10674618	10674691	E074	-20216
chr1	10723387	10724295	E074	28480
chr1	10725626	10725944	E074	30719
chr1	10725989	10726476	E074	31082
chr1	10726487	10726755	E074	31580
chr1	10672536	10673120	E081	-21787
chr1	10675435	10675632	E081	-19275
chr1	10676080	10676130	E081	-18777
chr1	10676190	10676279	E081	-18628
chr1	10676383	10676433	E081	-18474
chr1	10695242	10696319	E081	335
chr1	10699890	10700675	E081	4983
chr1	10700718	10700866	E081	5811
chr1	10700912	10701033	E081	6005
chr1	10711529	10711737	E081	16622
chr1	10711855	10712174	E081	16948
chr1	10722583	10722820	E081	27676
chr1	10722892	10722989	E081	27985
chr1	10723007	10723313	E081	28100
chr1	10723387	10724295	E081	28480
chr1	10724441	10724697	E081	29534
chr1	10731201	10731514	E081	36294
chr1	10731564	10731686	E081	36657
chr1	10731720	10732119	E081	36813
chr1	10733491	10733680	E081	38584
chr1	10737231	10738061	E081	42324
chr1	10738134	10738259	E081	43227
chr1	10738329	10738466	E081	43422
chr1	10738761	10738860	E081	43854
chr1	10738967	10740291	E081	44060
chr1	10742209	10742367	E081	47302
chr1	10742504	10743011	E081	47597
chr1	10743017	10743352	E081	48110
chr1	10743354	10743692	E081	48447
chr1	10652230	10652294	E082	-42613
chr1	10675435	10675632	E082	-19275
chr1	10694645	10695194	E082	0
chr1	10695242	10696319	E082	335
chr1	10723387	10724295	E082	28480
chr1	10724441	10724697	E082	29534
chr1	10738134	10738259	E082	43227
chr1	10738329	10738466	E082	43422
chr1	10738761	10738860	E082	43854
chr1	10742504	10743011	E082	47597
chr1	10743776	10743895	E082	48869

Promoter Annotation (GRCh37.p13)

Chromosome	Start	End	Region	Distance(-/+:Up/Downstream)
chr1	10698813	10698918	E070	3906
chr1	10698970	10699106	E070	4063
chr1	10699129	10699276	E070	4222
chr1	10698304	10698417	E082	3397
chr1	10698437	10698582	E082	3530
chr1	10698617	10698657	E082	3710
chr1	10698725	10698803	E082	3818
chr1	10698813	10698918	E082	3906
chr1	10698970	10699106	E082	4063
chr1	10699129	10699276	E082	4222