rs62059203

Homo sapiens
G>C
ZNRF1 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
C=0086 (2603/29960,GnomAD)
C=0108 (3148/29118,TOPMED)
C=0118 (592/5008,1000G)
C=0062 (240/3854,ALSPAC)
C=0065 (242/3708,TWINSUK)
chr16:75098967 (GRCh38.p7) (16q23.1)
CD
GWASdb2
1   publication(s)
See rs on genome
324 Enhancers around
21 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 16NC_000016.10:g.75098967G>C
GRCh37.p13 chr 16NC_000016.9:g.75132865G>C

Gene: ZNRF1, zinc and ring finger 1, E3 ubiquitin protein ligase(plus strand)

Molecule type Change Amino acid[Codon] SO Term
ZNRF1 transcriptNM_032268.4:c.N/AIntron Variant
ZNRF1 transcript variant X1XM_017023793.1:c.N/AIntron Variant
ZNRF1 transcript variant X3XM_011523392.1:c.N/AGenic Downstream Transcript Variant
ZNRF1 transcript variant X2XM_017023794.1:c.N/AGenic Downstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.812C=0.188
1000GenomesAmericanSub694G=0.790C=0.210
1000GenomesEast AsianSub1008G=0.948C=0.052
1000GenomesEuropeSub1006G=0.938C=0.062
1000GenomesGlobalStudy-wide5008G=0.882C=0.118
1000GenomesSouth AsianSub978G=0.920C=0.080
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.938C=0.062
The Genome Aggregation DatabaseAfricanSub8720G=0.858C=0.142
The Genome Aggregation DatabaseAmericanSub838G=0.820C=0.180
The Genome Aggregation DatabaseEast AsianSub1622G=0.956C=0.044
The Genome Aggregation DatabaseEuropeSub18478G=0.939C=0.060
The Genome Aggregation DatabaseGlobalStudy-wide29960G=0.913C=0.086
The Genome Aggregation DatabaseOtherSub302G=0.940C=0.060
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.891C=0.108
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.935C=0.065
PMID Title Author Journal
23958962Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene.Gelernter JMol Psychiatry

P-Value

SNP ID p-value Traits Study
rs620592030.000131Cocaine induced paranoia, AA23958962
rs620592030.000492Cocaine induced paranoia23958962

eQTL of rs62059203 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs62059203 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr167508760975087677E067-45188
chr167508791275088032E067-44833
chr167508807175088416E067-44449
chr167508848175088554E067-44311
chr167508861575088823E067-44042
chr167508885175088914E067-43951
chr167508898575089085E067-43780
chr167508934275089473E067-43392
chr167510363975103913E067-28952
chr167510396075104234E067-28631
chr167510430075104675E067-28190
chr167510765775108324E067-24541
chr167510839175108513E067-24352
chr167510901175110026E067-22839
chr167511518775115369E067-17496
chr167511557575115916E067-16949
chr167512076475121968E067-10897
chr167512198175122041E067-10824
chr167512210775122157E067-10708
chr167512219275122421E067-10444
chr167512818075128355E067-4510
chr167512848475128575E067-4290
chr167512857775128627E067-4238
chr167512890075128950E067-3915
chr167512913775129586E067-3279
chr167512967375129766E067-3099
chr167513178575133114E0670
chr167513312175134327E067256
chr167513437775134494E0671512
chr167513883575138906E0675970
chr167513903875139078E0676173
chr167513909375140293E0676228
chr167514255975146625E0679694
chr167514908475149192E06716219
chr167514921875149285E06716353
chr167514938375149448E06716518
chr167514946075149591E06716595
chr167514959275149652E06716727
chr167508760975087677E068-45188
chr167508791275088032E068-44833
chr167508807175088416E068-44449
chr167508848175088554E068-44311
chr167508861575088823E068-44042
chr167508885175088914E068-43951
chr167508898575089085E068-43780
chr167510363975103913E068-28952
chr167510396075104234E068-28631
chr167510765775108324E068-24541
chr167510839175108513E068-24352
chr167510901175110026E068-22839
chr167511518775115369E068-17496
chr167512076475121968E068-10897
chr167512198175122041E068-10824
chr167512210775122157E068-10708
chr167512219275122421E068-10444
chr167512249775122586E068-10279
chr167512264075122710E068-10155
chr167512279875122948E068-9917
chr167512848475128575E068-4290
chr167512857775128627E068-4238
chr167512890075128950E068-3915
chr167512913775129586E068-3279
chr167512967375129766E068-3099
chr167513178575133114E0680
chr167513312175134327E068256
chr167513903875139078E0686173
chr167513909375140293E0686228
chr167514040675140481E0687541
chr167514052175140648E0687656
chr167514078775141015E0687922
chr167514115175141377E0688286
chr167514139575141509E0688530
chr167514151775141676E0688652
chr167514168875141921E0688823
chr167514192575142163E0689060
chr167514227275142490E0689407
chr167514938375149448E06816518
chr167514946075149591E06816595
chr167514959275149652E06816727
chr167515102875151137E06818163
chr167508760975087677E069-45188
chr167508791275088032E069-44833
chr167508807175088416E069-44449
chr167508848175088554E069-44311
chr167508861575088823E069-44042
chr167508885175088914E069-43951
chr167508898575089085E069-43780
chr167508934275089473E069-43392
chr167509217675092244E069-40621
chr167509226475093068E069-39797
chr167510363975103913E069-28952
chr167510396075104234E069-28631
chr167510430075104675E069-28190
chr167510901175110026E069-22839
chr167512076475121968E069-10897
chr167512198175122041E069-10824
chr167512210775122157E069-10708
chr167512219275122421E069-10444
chr167512249775122586E069-10279
chr167512264075122710E069-10155
chr167512279875122948E069-9917
chr167512848475128575E069-4290
chr167512857775128627E069-4238
chr167512890075128950E069-3915
chr167512913775129586E069-3279
chr167512967375129766E069-3099
chr167513178575133114E0690
chr167513312175134327E069256
chr167513437775134494E0691512
chr167513457375134784E0691708
chr167513883575138906E0695970
chr167513903875139078E0696173
chr167513909375140293E0696228
chr167514040675140481E0697541
chr167514052175140648E0697656
chr167514227275142490E0699407
chr167514879475148933E06915929
chr167514908475149192E06916219
chr167508760975087677E070-45188
chr167508791275088032E070-44833
chr167508807175088416E070-44449
chr167508848175088554E070-44311
chr167508861575088823E070-44042
chr167508885175088914E070-43951
chr167508898575089085E070-43780
chr167511765275117702E070-15163
chr167514255975146625E0709694
chr167508791275088032E071-44833
chr167508807175088416E071-44449
chr167508848175088554E071-44311
chr167508861575088823E071-44042
chr167508885175088914E071-43951
chr167508898575089085E071-43780
chr167510363975103913E071-28952
chr167510396075104234E071-28631
chr167510430075104675E071-28190
chr167510901175110026E071-22839
chr167512076475121968E071-10897
chr167512198175122041E071-10824
chr167512210775122157E071-10708
chr167512219275122421E071-10444
chr167512249775122586E071-10279
chr167512784875127996E071-4869
chr167512799975128135E071-4730
chr167512818075128355E071-4510
chr167512848475128575E071-4290
chr167512857775128627E071-4238
chr167512890075128950E071-3915
chr167512913775129586E071-3279
chr167512967375129766E071-3099
chr167513178575133114E0710
chr167513312175134327E071256
chr167513437775134494E0711512
chr167513457375134784E0711708
chr167513829875138449E0715433
chr167513850575138599E0715640
chr167513862775138733E0715762
chr167513883575138906E0715970
chr167513903875139078E0716173
chr167513909375140293E0716228
chr167514040675140481E0717541
chr167514052175140648E0717656
chr167514078775141015E0717922
chr167514115175141377E0718286
chr167514139575141509E0718530
chr167514151775141676E0718652
chr167514168875141921E0718823
chr167514192575142163E0719060
chr167514227275142490E0719407
chr167514255975146625E0719694
chr167514771275147834E07114847
chr167514785575148076E07114990
chr167514811875148200E07115253
chr167514908475149192E07116219
chr167508791275088032E072-44833
chr167508807175088416E072-44449
chr167508848175088554E072-44311
chr167508861575088823E072-44042
chr167508885175088914E072-43951
chr167508898575089085E072-43780
chr167508934275089473E072-43392
chr167509226475093068E072-39797
chr167510363975103913E072-28952
chr167510396075104234E072-28631
chr167510430075104675E072-28190
chr167510901175110026E072-22839
chr167511518775115369E072-17496
chr167512076475121968E072-10897
chr167512249775122586E072-10279
chr167512818075128355E072-4510
chr167512848475128575E072-4290
chr167512857775128627E072-4238
chr167512890075128950E072-3915
chr167512913775129586E072-3279
chr167512967375129766E072-3099
chr167512983275130181E072-2684
chr167513045475131046E072-1819
chr167513106975131188E072-1677
chr167513124875131481E072-1384
chr167513178575133114E0720
chr167513312175134327E072256
chr167513437775134494E0721512
chr167513457375134784E0721708
chr167513862775138733E0725762
chr167513883575138906E0725970
chr167513903875139078E0726173
chr167513909375140293E0726228
chr167514078775141015E0727922
chr167514811875148200E07215253
chr167514847675148634E07215611
chr167514866375148724E07215798
chr167514879475148933E07215929
chr167514908475149192E07216219
chr167508791275088032E073-44833
chr167508807175088416E073-44449
chr167508848175088554E073-44311
chr167508861575088823E073-44042
chr167508885175088914E073-43951
chr167508898575089085E073-43780
chr167508934275089473E073-43392
chr167509217675092244E073-40621
chr167509226475093068E073-39797
chr167510363975103913E073-28952
chr167510396075104234E073-28631
chr167510901175110026E073-22839
chr167511518775115369E073-17496
chr167511557575115916E073-16949
chr167512076475121968E073-10897
chr167512198175122041E073-10824
chr167512210775122157E073-10708
chr167512890075128950E073-3915
chr167513178575133114E0730
chr167513312175134327E073256
chr167513811975138204E0735254
chr167513829875138449E0735433
chr167513850575138599E0735640
chr167513862775138733E0735762
chr167513883575138906E0735970
chr167513903875139078E0736173
chr167513909375140293E0736228
chr167514040675140481E0737541
chr167514052175140648E0737656
chr167514921875149285E07316353
chr167514938375149448E07316518
chr167508791275088032E074-44833
chr167508807175088416E074-44449
chr167508848175088554E074-44311
chr167508861575088823E074-44042
chr167508885175088914E074-43951
chr167508898575089085E074-43780
chr167508934275089473E074-43392
chr167509217675092244E074-40621
chr167509226475093068E074-39797
chr167510363975103913E074-28952
chr167510396075104234E074-28631
chr167510430075104675E074-28190
chr167510901175110026E074-22839
chr167512076475121968E074-10897
chr167512198175122041E074-10824
chr167512210775122157E074-10708
chr167512219275122421E074-10444
chr167512249775122586E074-10279
chr167512818075128355E074-4510
chr167512848475128575E074-4290
chr167512857775128627E074-4238
chr167512890075128950E074-3915
chr167512913775129586E074-3279
chr167512967375129766E074-3099
chr167512983275130181E074-2684
chr167513124875131481E074-1384
chr167513178575133114E0740
chr167513312175134327E074256
chr167513437775134494E0741512
chr167513829875138449E0745433
chr167513850575138599E0745640
chr167513862775138733E0745762
chr167513883575138906E0745970
chr167513903875139078E0746173
chr167513909375140293E0746228
chr167514040675140481E0747541
chr167514052175140648E0747656
chr167514078775141015E0747922
chr167514115175141377E0748286
chr167514139575141509E0748530
chr167514255975146625E0749694
chr167514908475149192E07416219
chr167514921875149285E07416353
chr167514938375149448E07416518
chr167514946075149591E07416595
chr167514959275149652E07416727
chr167508861575088823E081-44042
chr167508885175088914E081-43951
chr167508898575089085E081-43780
chr167509590675097259E081-35606
chr167510363975103913E081-28952
chr167510396075104234E081-28631
chr167510720275107312E081-25553
chr167510748375107614E081-25251
chr167510765775108324E081-24541
chr167510839175108513E081-24352
chr167510901175110026E081-22839
chr167514255975146625E0819694
chr167514959275149652E08116727
chr167508760975087677E082-45188
chr167508791275088032E082-44833
chr167508807175088416E082-44449
chr167508848175088554E082-44311
chr167508861575088823E082-44042
chr167508885175088914E082-43951
chr167508898575089085E082-43780
chr167508934275089473E082-43392
chr167510363975103913E082-28952
chr167510396075104234E082-28631
chr167510430075104675E082-28190
chr167510748375107614E082-25251
chr167510765775108324E082-24541
chr167510839175108513E082-24352
chr167510853575108625E082-24240
chr167510868775108799E082-24066
chr167510885375108982E082-23883
chr167510901175110026E082-22839
chr167514255975146625E0829694
chr167514664575146800E08213780
chr167514685275147340E08213987










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr167514994775150119E06717082
chr167515021675151011E06717351
chr167518185075182061E06748985
chr167514994775150119E06817082
chr167515021675151011E06817351
chr167518185075182061E06848985
chr167514994775150119E06917082
chr167515021675151011E06917351
chr167518185075182061E06948985
chr167515021675151011E07017351
chr167518185075182061E07048985
chr167514994775150119E07117082
chr167515021675151011E07117351
chr167514994775150119E07217082
chr167515021675151011E07217351
chr167518185075182061E07248985
chr167514994775150119E07317082
chr167515021675151011E07317351
chr167514994775150119E07417082
chr167515021675151011E07417351
chr167518185075182061E07448985