rs62103177

Homo sapiens
G>A
KCNG2 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
A=0102 (3058/29822,GnomAD)
A=0111 (3256/29116,TOPMED)
A=0073 (364/5008,1000G)
A=0148 (569/3854,ALSPAC)
A=0143 (529/3708,TWINSUK)
chr18:79864479 (GRCh38.p7) (18q23)
OD
GWASdb2 | GWASCatalog
2   publication(s)
See rs on genome
94 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 18NC_000018.10:g.79864479G>A
GRCh37.p13 chr 18NC_000018.9:g.77624479G>A

Gene: KCNG2, potassium voltage-gated channel modifier subfamily G member 2(plus strand)

Molecule type Change Amino acid[Codon] SO Term
KCNG2 transcriptNM_012283.1:c.N/AIntron Variant
KCNG2 transcript variant X2XM_011525918.2:c.N/AIntron Variant
KCNG2 transcript variant X4XM_011525920.2:c.N/AIntron Variant
KCNG2 transcript variant X1XM_017025704.1:c.N/AIntron Variant
KCNG2 transcript variant X3XM_017025705.1:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.956A=0.044
1000GenomesAmericanSub694G=0.900A=0.100
1000GenomesEast AsianSub1008G=0.966A=0.034
1000GenomesEuropeSub1006G=0.851A=0.149
1000GenomesGlobalStudy-wide5008G=0.927A=0.073
1000GenomesSouth AsianSub978G=0.950A=0.050
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.852A=0.148
The Genome Aggregation DatabaseAfricanSub8690G=0.933A=0.067
The Genome Aggregation DatabaseAmericanSub834G=0.900A=0.100
The Genome Aggregation DatabaseEast AsianSub1616G=0.977A=0.023
The Genome Aggregation DatabaseEuropeSub18380G=0.875A=0.124
The Genome Aggregation DatabaseGlobalStudy-wide29822G=0.897A=0.102
The Genome Aggregation DatabaseOtherSub302G=0.810A=0.190
Trans-Omics for Precision MedicineGlobalStudy-wide29116G=0.888A=0.111
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.857A=0.143
PMID Title Author Journal
26044620Gene network analysis shows immune-signaling and ERK1/2 as novel genetic markers for multiple addiction phenotypes: alcohol, smoking and opioid addiction.Reyes-Gibby CCBMC Syst Biol
24143882Genome-wide association study of opioid dependence: multiple associations mapped to calcium and potassium pathways.Gelernter JBiol Psychiatry

P-Value

SNP ID p-value Traits Study
rs621031774E-10Opioid sensitivity24143882

eQTL of rs62103177 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
Chr18:77624479RBFADNENSG00000261126.3G>A1.8371e-21-182421Cerebellum
Chr18:77624479RBFADNENSG00000261126.3G>A2.1242e-10-182421Frontal_Cortex_BA9
Chr18:77624479RBFADNENSG00000261126.3G>A2.3662e-12-182421Cortex
Chr18:77624479RBFADNENSG00000261126.3G>A1.0885e-18-182421Cerebellar_Hemisphere
Chr18:77624479RBFADNENSG00000261126.3G>A1.9838e-14-182421Caudate_basal_ganglia
Chr18:77624479RBFADNENSG00000261126.3G>A2.4022e-9-182421Hippocampus

meQTL of rs62103177 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr187763052077630972E0676041
chr187763123477631309E0676755
chr187763139977631502E0676920
chr187763678777636968E06712308
chr187767231177672984E06747832
chr187767317377673356E06748694
chr187767339177673466E06748912
chr187761642077617762E068-6717
chr187763658377636745E06812104
chr187763678777636968E06812308
chr187763724377637454E06812764
chr187763753077637827E06813051
chr187757922577579328E069-45151
chr187757939277579445E069-45034
chr187761642077617762E069-6717
chr187763123477631309E0696755
chr187763139977631502E0696920
chr187763165677631742E0697177
chr187763181377631969E0697334
chr187763201177632061E0697532
chr187763678777636968E06912308
chr187767231177672984E06947832
chr187761642077617762E070-6717
chr187763052077630972E0706041
chr187763123477631309E0706755
chr187763139977631502E0706920
chr187767198277672208E07047503
chr187761642077617762E071-6717
chr187763052077630972E0716041
chr187763123477631309E0716755
chr187763139977631502E0716920
chr187763165677631742E0717177
chr187763181377631969E0717334
chr187763201177632061E0717532
chr187763209377632254E0717614
chr187763658377636745E07112104
chr187763678777636968E07112308
chr187764178777641857E07117308
chr187766529577665367E07140816
chr187766539177665441E07140912
chr187766546577665518E07140986
chr187766560977665659E07141130
chr187766570777665938E07141228
chr187766613577666195E07141656
chr187767317377673356E07148694
chr187767339177673466E07148912
chr187767353177673711E07149052
chr187757995777580546E072-43933
chr187763052077630972E0726041
chr187763123477631309E0726755
chr187763139977631502E0726920
chr187763165677631742E0727177
chr187763181377631969E0727334
chr187763201177632061E0727532
chr187763209377632254E0727614
chr187763658377636745E07212104
chr187763678777636968E07212308
chr187764178777641857E07217308
chr187764211677642166E07217637
chr187764217077642251E07217691
chr187767198277672208E07247503
chr187767231177672984E07247832
chr187767317377673356E07248694
chr187763790377638045E07313424
chr187767072577670812E07346246
chr187767109577671212E07346616
chr187767198277672208E07347503
chr187767231177672984E07347832
chr187767317377673356E07348694
chr187761642077617762E074-6717
chr187763678777636968E07412308
chr187763724377637454E07412764
chr187763052077630972E0816041
chr187763123477631309E0816755
chr187763139977631502E0816920
chr187763165677631742E0817177
chr187763181377631969E0817334
chr187763201177632061E0817532
chr187763209377632254E0817614
chr187763252077632807E0818041
chr187763297177633255E0818492
chr187763678777636968E08112308
chr187763724377637454E08112764
chr187763753077637827E08113051
chr187767198277672208E08147503
chr187763052077630972E0826041
chr187763123477631309E0826755
chr187763139977631502E0826920
chr187763165677631742E0827177
chr187763181377631969E0827334
chr187763201177632061E0827532
chr187763209377632254E0827614
chr187763252077632807E0828041
chr187763297177633255E0828492