rs641221

Organism: Homo sapiens

Alleles: A>G

Gene : Feature

ZFR : Intron Variant

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

G=0425 (12720/29904,GnomAD)
G=0401 (11683/29118,TOPMED)
G=0443 (2218/5008,1000G)
G=0445 (1715/3854,ALSPAC)
G=0427 (1585/3708,TWINSUK)

Position: chr5:32439218 (GRCh38.p7) (5p13.3)

Phenotype: AD

Dataset:

GWASdb2

Publications: 2 publication(s)

Genomic View: See rs on genome

Enhancer: 72 Enhancers around

Promoter: 10 Promoters around

Variant Details Frequency Publications p-values eSNP meSNP

Genomic Coordinates

Sequence Name	Change(s)
GRCh38.p7 chr 5	NC_000005.10:g.32439218A>G
GRCh37.p13 chr 5	NC_000005.9:g.32439324A>G

Gene: ZFR, zinc finger RNA binding protein(minus strand)

Molecule type	Change	Amino acid[Codon]	SO Term
ZFR transcript	NM_016107.3:c.	N/A	Intron Variant
ZFR transcript variant X1	XR_427659.2:n.	N/A	Intron Variant

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	A=0.637	G=0.363
1000Genomes	American	Sub	694	A=0.550	G=0.450
1000Genomes	East Asian	Sub	1008	A=0.444	G=0.556
1000Genomes	Europe	Sub	1006	A=0.575	G=0.425
1000Genomes	Global	Study-wide	5008	A=0.557	G=0.443
1000Genomes	South Asian	Sub	978	A=0.550	G=0.450
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	A=0.555	G=0.445
The Genome Aggregation Database	African	Sub	8696	A=0.645	G=0.355
The Genome Aggregation Database	American	Sub	836	A=0.550	G=0.450
The Genome Aggregation Database	East Asian	Sub	1612	A=0.427	G=0.573
The Genome Aggregation Database	Europe	Sub	18458	A=0.555	G=0.444
The Genome Aggregation Database	Global	Study-wide	29904	A=0.574	G=0.425
The Genome Aggregation Database	Other	Sub	302	A=0.580	G=0.420
Trans-Omics for Precision Medicine	Global	Study-wide	29118	A=0.598	G=0.401
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	A=0.573	G=0.427

PMID	Title	Author	Journal
21314694	Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample.	Kendler KS	Alcohol Clin Exp Res
16400611	Genomewide linkage scan of 409 European-ancestry and African American families with schizophrenia: suggestive evidence of linkage at 8p23.3-p21.2 and 11p13.1-q14.1 in the combined sample.	Suarez BK	Am J Hum Genet

SNP ID	p-value	Traits	Study
rs641221	0.000756	alcohol dependence	21314694

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome	Start	End	Region	Distance ( -/+ : Up/Downstream )
chr5	32410859	32411060	E067	-28264
chr5	32414235	32414485	E067	-24839
chr5	32419946	32420225	E067	-19099
chr5	32420720	32420906	E067	-18418
chr5	32421068	32421112	E067	-18212
chr5	32421319	32421412	E067	-17912
chr5	32421567	32421624	E067	-17700
chr5	32422240	32422284	E067	-17040
chr5	32428792	32428856	E067	-10468
chr5	32439341	32439502	E067	17
chr5	32439598	32439715	E067	274
chr5	32390940	32391592	E068	-47732
chr5	32420720	32420906	E068	-18418
chr5	32421068	32421112	E068	-18212
chr5	32421319	32421412	E068	-17912
chr5	32428792	32428856	E068	-10468
chr5	32435860	32435940	E068	-3384
chr5	32461444	32461596	E068	22120
chr5	32461758	32461819	E068	22434
chr5	32475556	32475851	E068	36232
chr5	32390940	32391592	E069	-47732
chr5	32391649	32391740	E069	-47584
chr5	32421068	32421112	E069	-18212
chr5	32421319	32421412	E069	-17912
chr5	32421567	32421624	E069	-17700
chr5	32422240	32422284	E069	-17040
chr5	32424132	32424233	E069	-15091
chr5	32439341	32439502	E069	17
chr5	32390940	32391592	E071	-47732
chr5	32414235	32414485	E071	-24839
chr5	32419946	32420225	E071	-19099
chr5	32420720	32420906	E071	-18418
chr5	32421068	32421112	E071	-18212
chr5	32421319	32421412	E071	-17912
chr5	32421567	32421624	E071	-17700
chr5	32422240	32422284	E071	-17040
chr5	32424132	32424233	E071	-15091
chr5	32424279	32424341	E071	-14983
chr5	32436835	32436958	E071	-2366
chr5	32437005	32437193	E071	-2131
chr5	32439341	32439502	E071	17
chr5	32439598	32439715	E071	274
chr5	32445585	32445902	E071	6261
chr5	32390940	32391592	E072	-47732
chr5	32391649	32391740	E072	-47584
chr5	32410859	32411060	E072	-28264
chr5	32419946	32420225	E072	-19099
chr5	32420720	32420906	E072	-18418
chr5	32435382	32435557	E072	-3767
chr5	32439598	32439715	E072	274
chr5	32439813	32439873	E072	489
chr5	32445585	32445902	E072	6261
chr5	32419946	32420225	E073	-19099
chr5	32420720	32420906	E073	-18418
chr5	32435860	32435940	E073	-3384
chr5	32445585	32445902	E073	6261
chr5	32390836	32390905	E074	-48419
chr5	32390940	32391592	E074	-47732
chr5	32391649	32391740	E074	-47584
chr5	32392240	32392412	E074	-46912
chr5	32410859	32411060	E074	-28264
chr5	32412107	32412211	E074	-27113
chr5	32412731	32412871	E074	-26453
chr5	32414235	32414485	E074	-24839
chr5	32424132	32424233	E074	-15091
chr5	32424279	32424341	E074	-14983
chr5	32428792	32428856	E074	-10468
chr5	32439341	32439502	E074	17
chr5	32439598	32439715	E074	274
chr5	32445585	32445902	E074	6261
chr5	32445585	32445902	E081	6261
chr5	32446005	32446066	E081	6681

Promoter Annotation (GRCh37.p13)

Chromosome	Start	End	Region	Distance(-/+:Up/Downstream)
chr5	32443218	32445582	E067	3894
chr5	32443218	32445582	E068	3894
chr5	32443218	32445582	E069	3894
chr5	32443218	32445582	E070	3894
chr5	32443218	32445582	E071	3894
chr5	32443218	32445582	E072	3894
chr5	32443218	32445582	E073	3894
chr5	32443218	32445582	E074	3894
chr5	32443218	32445582	E081	3894
chr5	32443218	32445582	E082	3894

rs641221

Genomic Coordinates

Gene: ZFR, zinc finger RNA binding protein(minus strand)

Population Frequency

P-Value

eQTL of rs641221 in Brain tissues (GTEx Analysis Release V7)

meQTL of rs641221 in Fetal Brain

Genomic View

Chromatin Interaction

Enhancer Annotation (GRCh37.p13)

Promoter Annotation (GRCh37.p13)