rs641221

Homo sapiens
A>G
ZFR : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
G=0425 (12720/29904,GnomAD)
G=0401 (11683/29118,TOPMED)
G=0443 (2218/5008,1000G)
G=0445 (1715/3854,ALSPAC)
G=0427 (1585/3708,TWINSUK)
chr5:32439218 (GRCh38.p7) (5p13.3)
AD
GWASdb2
2   publication(s)
See rs on genome
72 Enhancers around
10 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 5NC_000005.10:g.32439218A>G
GRCh37.p13 chr 5NC_000005.9:g.32439324A>G

Gene: ZFR, zinc finger RNA binding protein(minus strand)

Molecule type Change Amino acid[Codon] SO Term
ZFR transcriptNM_016107.3:c.N/AIntron Variant
ZFR transcript variant X1XR_427659.2:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.637G=0.363
1000GenomesAmericanSub694A=0.550G=0.450
1000GenomesEast AsianSub1008A=0.444G=0.556
1000GenomesEuropeSub1006A=0.575G=0.425
1000GenomesGlobalStudy-wide5008A=0.557G=0.443
1000GenomesSouth AsianSub978A=0.550G=0.450
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.555G=0.445
The Genome Aggregation DatabaseAfricanSub8696A=0.645G=0.355
The Genome Aggregation DatabaseAmericanSub836A=0.550G=0.450
The Genome Aggregation DatabaseEast AsianSub1612A=0.427G=0.573
The Genome Aggregation DatabaseEuropeSub18458A=0.555G=0.444
The Genome Aggregation DatabaseGlobalStudy-wide29904A=0.574G=0.425
The Genome Aggregation DatabaseOtherSub302A=0.580G=0.420
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.598G=0.401
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.573G=0.427
PMID Title Author Journal
21314694Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample.Kendler KSAlcohol Clin Exp Res
16400611Genomewide linkage scan of 409 European-ancestry and African American families with schizophrenia: suggestive evidence of linkage at 8p23.3-p21.2 and 11p13.1-q14.1 in the combined sample.Suarez BKAm J Hum Genet

P-Value

SNP ID p-value Traits Study
rs6412210.000756alcohol dependence21314694

eQTL of rs641221 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs641221 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr53241085932411060E067-28264
chr53241423532414485E067-24839
chr53241994632420225E067-19099
chr53242072032420906E067-18418
chr53242106832421112E067-18212
chr53242131932421412E067-17912
chr53242156732421624E067-17700
chr53242224032422284E067-17040
chr53242879232428856E067-10468
chr53243934132439502E06717
chr53243959832439715E067274
chr53239094032391592E068-47732
chr53242072032420906E068-18418
chr53242106832421112E068-18212
chr53242131932421412E068-17912
chr53242879232428856E068-10468
chr53243586032435940E068-3384
chr53246144432461596E06822120
chr53246175832461819E06822434
chr53247555632475851E06836232
chr53239094032391592E069-47732
chr53239164932391740E069-47584
chr53242106832421112E069-18212
chr53242131932421412E069-17912
chr53242156732421624E069-17700
chr53242224032422284E069-17040
chr53242413232424233E069-15091
chr53243934132439502E06917
chr53239094032391592E071-47732
chr53241423532414485E071-24839
chr53241994632420225E071-19099
chr53242072032420906E071-18418
chr53242106832421112E071-18212
chr53242131932421412E071-17912
chr53242156732421624E071-17700
chr53242224032422284E071-17040
chr53242413232424233E071-15091
chr53242427932424341E071-14983
chr53243683532436958E071-2366
chr53243700532437193E071-2131
chr53243934132439502E07117
chr53243959832439715E071274
chr53244558532445902E0716261
chr53239094032391592E072-47732
chr53239164932391740E072-47584
chr53241085932411060E072-28264
chr53241994632420225E072-19099
chr53242072032420906E072-18418
chr53243538232435557E072-3767
chr53243959832439715E072274
chr53243981332439873E072489
chr53244558532445902E0726261
chr53241994632420225E073-19099
chr53242072032420906E073-18418
chr53243586032435940E073-3384
chr53244558532445902E0736261
chr53239083632390905E074-48419
chr53239094032391592E074-47732
chr53239164932391740E074-47584
chr53239224032392412E074-46912
chr53241085932411060E074-28264
chr53241210732412211E074-27113
chr53241273132412871E074-26453
chr53241423532414485E074-24839
chr53242413232424233E074-15091
chr53242427932424341E074-14983
chr53242879232428856E074-10468
chr53243934132439502E07417
chr53243959832439715E074274
chr53244558532445902E0746261
chr53244558532445902E0816261
chr53244600532446066E0816681








Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr53244321832445582E0673894
chr53244321832445582E0683894
chr53244321832445582E0693894
chr53244321832445582E0703894
chr53244321832445582E0713894
chr53244321832445582E0723894
chr53244321832445582E0733894
chr53244321832445582E0743894
chr53244321832445582E0813894
chr53244321832445582E0823894