rs6425323

Homo sapiens
C>T
None
Check p-value
SNV (Single Nucleotide Variation)
T=0405 (12130/29904,GnomAD)
T=0361 (10529/29118,TOPMED)
T=0285 (1428/5008,1000G)
T=0464 (1787/3854,ALSPAC)
T=0486 (1803/3708,TWINSUK)
chr1:175155900 (GRCh38.p7) (1q25.1)
AD
GWASdb2
4   publication(s)
See rs on genome
27 Enhancers around
8 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 1NC_000001.11:g.175155900C>T
GRCh37.p13 chr 1NC_000001.10:g.175125036C>T

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.674T=0.326
1000GenomesAmericanSub694C=0.690T=0.310
1000GenomesEast AsianSub1008C=0.901T=0.099
1000GenomesEuropeSub1006C=0.553T=0.447
1000GenomesGlobalStudy-wide5008C=0.715T=0.285
1000GenomesSouth AsianSub978C=0.760T=0.240
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.536T=0.464
The Genome Aggregation DatabaseAfricanSub8712C=0.665T=0.335
The Genome Aggregation DatabaseAmericanSub838C=0.740T=0.260
The Genome Aggregation DatabaseEast AsianSub1616C=0.897T=0.103
The Genome Aggregation DatabaseEuropeSub18438C=0.526T=0.474
The Genome Aggregation DatabaseGlobalStudy-wide29904C=0.594T=0.405
The Genome Aggregation DatabaseOtherSub300C=0.710T=0.290
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.638T=0.361
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.514T=0.486
PMID Title Author Journal
21703634A meta-analysis of two genome-wide association studies identifies 3 new loci for alcohol dependence.Wang KSJ Psychiatr Res
23365539Large scale association analysis for drug addiction: results from SNP to gene.Guo XScientificWorldJournal
20202923A genome-wide association study of alcohol dependence.Bierut LJProc Natl Acad Sci U S A
21956439Genome-wide association study of alcohol dependence implicates KIAA0040 on chromosome 1q.Zuo LNeuropsychopharmacology

P-Value

SNP ID p-value Traits Study
rs64253230.000000313alcohol dependence21703634
rs64253230.00000227alcohol dependence20202923
rs64253230.00028alcohol dependence21956439

eQTL of rs6425323 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs6425323 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr1175127262175127638E0672226
chr1175127726175127793E0672690
chr1175121212175121706E069-3330
chr1175138495175138718E06913459
chr1175117508175117593E070-7443
chr1175131566175131616E0706530
chr1175131702175131793E0706666
chr1175131845175132044E0706809
chr1175132208175132358E0707172
chr1175169465175169525E07144429
chr1175169774175170871E07144738
chr1175121212175121706E072-3330
chr1175173548175173704E07348512
chr1175173714175173889E07348678
chr1175115170175115364E081-9672
chr1175115429175115500E081-9536
chr1175115737175116333E081-8703
chr1175116438175116534E081-8502
chr1175116763175117071E081-7965
chr1175117325175117401E081-7635
chr1175117508175117593E081-7443
chr1175120951175121040E081-3996
chr1175121212175121706E081-3330
chr1175127262175127638E0822226
chr1175127726175127793E0822690
chr1175173548175173704E08248512
chr1175173714175173889E08248678








Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr1175160861175163201E06735825
chr1175160861175163201E06835825
chr1175160861175163201E06935825
chr1175160861175163201E07135825
chr1175160861175163201E07235825
chr1175160861175163201E07335825
chr1175160861175163201E07435825
chr1175160861175163201E08235825