rs6432321

Homo sapiens
T>C
None
Check p-value
SNV (Single Nucleotide Variation)
T==0173 (5198/29968,GnomAD)
T==0162 (4738/29116,TOPMED)
T==0159 (796/5008,1000G)
T==0194 (746/3854,ALSPAC)
T==0180 (668/3708,TWINSUK)
chr2:12638219 (GRCh38.p7) (2p24.3)
AD
GWASdb2
1   publication(s)
See rs on genome
17 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 2NC_000002.12:g.12638219T>C
GRCh37.p13 chr 2NC_000002.11:g.12778345T>C

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.131C=0.869
1000GenomesAmericanSub694T=0.190C=0.810
1000GenomesEast AsianSub1008T=0.098C=0.902
1000GenomesEuropeSub1006T=0.197C=0.803
1000GenomesGlobalStudy-wide5008T=0.159C=0.841
1000GenomesSouth AsianSub978T=0.200C=0.800
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.194C=0.806
The Genome Aggregation DatabaseAfricanSub8722T=0.116C=0.884
The Genome Aggregation DatabaseAmericanSub838T=0.220C=0.780
The Genome Aggregation DatabaseEast AsianSub1620T=0.151C=0.849
The Genome Aggregation DatabaseEuropeSub18486T=0.200C=0.799
The Genome Aggregation DatabaseGlobalStudy-wide29968T=0.173C=0.826
The Genome Aggregation DatabaseOtherSub302T=0.180C=0.820
Trans-Omics for Precision MedicineGlobalStudy-wide29116T=0.162C=0.837
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.180C=0.820
PMID Title Author Journal
24277619ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.Quillen EEAm J Med Genet B Neuropsychiatr Genet

P-Value

SNP ID p-value Traits Study
rs64323210.000225alcohol dependence24277619

eQTL of rs6432321 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs6432321 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr21275329212753547E067-24798
chr21275366512753897E067-24448
chr21273708112737248E068-41097
chr21273779112738157E068-40188
chr21275329212753547E068-24798
chr21282447212825118E06846127
chr21274619912746317E069-32028
chr21274636712747109E069-31236
chr21275329212753547E069-24798
chr21274636712747109E070-31236
chr21275289712753012E072-25333
chr21275329212753547E072-24798
chr21275366512753897E072-24448
chr21280349812803830E07325153
chr21280400412804124E07325659
chr21275289712753012E082-25333
chr21275329212753547E082-24798