rs6450184

Homo sapiens
G>C
ARL15 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
G==0382 (11451/29916,GnomAD)
G==0414 (12067/29118,TOPMED)
G==0463 (2318/5008,1000G)
G==0314 (1210/3854,ALSPAC)
G==0310 (1149/3708,TWINSUK)
chr5:54286675 (GRCh38.p7) (5q11.2)
AD
GWASdb2
1   publication(s)
See rs on genome
26 Enhancers around
11 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 5NC_000005.10:g.54286675G>C
GRCh37.p13 chr 5NC_000005.9:g.53582505G>C

Gene: ARL15, ADP ribosylation factor like GTPase 15(minus strand)

Molecule type Change Amino acid[Codon] SO Term
ARL15 transcriptNM_019087.2:c.N/AIntron Variant
ARL15 transcript variant X1XM_011543498.2:c.N/AIntron Variant
ARL15 transcript variant X2XM_011543499.2:c.N/AIntron Variant
ARL15 transcript variant X3XM_011543500.2:c.N/AIntron Variant
ARL15 transcript variant X4XM_017009598.1:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.524C=0.476
1000GenomesAmericanSub694G=0.540C=0.460
1000GenomesEast AsianSub1008G=0.577C=0.423
1000GenomesEuropeSub1006G=0.316C=0.684
1000GenomesGlobalStudy-wide5008G=0.463C=0.537
1000GenomesSouth AsianSub978G=0.360C=0.640
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.314C=0.686
The Genome Aggregation DatabaseAfricanSub8694G=0.502C=0.498
The Genome Aggregation DatabaseAmericanSub832G=0.530C=0.470
The Genome Aggregation DatabaseEast AsianSub1614G=0.611C=0.389
The Genome Aggregation DatabaseEuropeSub18474G=0.302C=0.697
The Genome Aggregation DatabaseGlobalStudy-wide29916G=0.382C=0.617
The Genome Aggregation DatabaseOtherSub302G=0.240C=0.760
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.414C=0.585
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.310C=0.690
PMID Title Author Journal
24962325Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families.Kapoor MDrug Alcohol Depend

P-Value

SNP ID p-value Traits Study
rs64501849.42E-07alcohol dependence (age at onset)24962325

eQTL of rs6450184 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs6450184 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr55359219153592302E0679686
chr55359230553592489E0679800
chr55360474653604828E06722241
chr55359156353591979E0689058
chr55359219153592302E0689686
chr55359230553592489E0689800
chr55357394153574185E069-8320
chr55357422253574433E069-8072
chr55360335753603465E07020852
chr55360351753603786E07021012
chr55360440353604546E07021898
chr55360474653604828E07122241
chr55357394153574185E072-8320
chr55357422253574433E072-8072
chr55357444553574505E072-8000
chr55357422253574433E074-8072
chr55357444553574505E074-8000
chr55359119253591246E0748687
chr55359156353591979E0749058
chr55359219153592302E0749686
chr55359230553592489E0749800
chr55360351753603786E08121012
chr55360427953604329E08121774
chr55360440353604546E08121898
chr55360474653604828E08122241
chr55360803253608085E08125527








Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr55360503053607991E06722525
chr55360503053607991E06822525
chr55360503053607991E06922525
chr55360503053607991E07022525
chr55355060653550896E071-31609
chr55360503053607991E07122525
chr55360503053607991E07222525
chr55360503053607991E07322525
chr55360503053607991E07422525
chr55360503053607991E08122525
chr55360503053607991E08222525