rs6458004

Homo sapiens
T>C
None
Check p-value
SNV (Single Nucleotide Variation)
T==0370 (11094/29938,GnomAD)
T==0301 (8784/29118,TOPMED)
T==0425 (2128/5008,1000G)
T==0390 (1502/3854,ALSPAC)
T==0401 (1487/3708,TWINSUK)
chr6:37594927 (GRCh38.p7) (6p21.2)
AD
GWASdb2
1   publication(s)
See rs on genome
120 Enhancers around
19 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 6NC_000006.12:g.37594927T>C
GRCh37.p13 chr 6NC_000006.11:g.37562703T>C

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.159C=0.841
1000GenomesAmericanSub694T=0.440C=0.560
1000GenomesEast AsianSub1008T=0.810C=0.190
1000GenomesEuropeSub1006T=0.375C=0.625
1000GenomesGlobalStudy-wide5008T=0.425C=0.575
1000GenomesSouth AsianSub978T=0.430C=0.570
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.390C=0.610
The Genome Aggregation DatabaseAfricanSub8724T=0.200C=0.800
The Genome Aggregation DatabaseAmericanSub834T=0.410C=0.590
The Genome Aggregation DatabaseEast AsianSub1618T=0.831C=0.169
The Genome Aggregation DatabaseEuropeSub18464T=0.411C=0.588
The Genome Aggregation DatabaseGlobalStudy-wide29938T=0.370C=0.629
The Genome Aggregation DatabaseOtherSub298T=0.200C=0.800
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.301C=0.698
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.401C=0.599
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs64580040.000829alcohol dependence20201924

eQTL of rs6458004 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs6458004 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr63752691837527006E067-35697
chr63752691837527006E069-35697
chr63758694437587318E06924241
chr63751532637516107E070-46596
chr63751976537519969E070-42734
chr63752002237520212E070-42491
chr63752287237522964E070-39739
chr63752308137523294E070-39409
chr63752550837525569E070-37134
chr63752594337525993E070-36710
chr63752604537526302E070-36401
chr63752691837527006E070-35697
chr63752910937529340E070-33363
chr63752974437530325E070-32378
chr63753080737530912E070-31791
chr63753101337531077E070-31626
chr63753139037531436E070-31267
chr63753156437531661E070-31042
chr63753213237532182E070-30521
chr63753455637534741E070-27962
chr63753485237534976E070-27727
chr63753504737535167E070-27536
chr63753764637537947E070-24756
chr63753796437538014E070-24689
chr63755568237556076E070-6627
chr63755615237556402E070-6301
chr63755641937556531E070-6172
chr63755653737556658E070-6045
chr63755780037558042E070-4661
chr63758668237586725E07023979
chr63758673837586824E07024035
chr63758694437587318E07024241
chr63758753737587591E07024834
chr63759196837592105E07029265
chr63759214137592279E07029438
chr63759398037594030E07031277
chr63757580237576025E07113099
chr63757607937576159E07113376
chr63758673837586824E07124035
chr63758694437587318E07124241
chr63752691837527006E072-35697
chr63752731037528654E072-34049
chr63753455637534741E072-27962
chr63759640337596750E07233700
chr63752691837527006E073-35697
chr63752731037528654E073-34049
chr63758694437587318E07324241
chr63753455637534741E074-27962
chr63751690037517184E081-45519
chr63751722337517353E081-45350
chr63751750037517589E081-45114
chr63751931037519487E081-43216
chr63751976537519969E081-42734
chr63752002237520212E081-42491
chr63752042137520471E081-42232
chr63752136837521757E081-40946
chr63752213137522190E081-40513
chr63752235637522558E081-40145
chr63752287237522964E081-39739
chr63752308137523294E081-39409
chr63752462137524843E081-37860
chr63752550837525569E081-37134
chr63752594337525993E081-36710
chr63752604537526302E081-36401
chr63752691837527006E081-35697
chr63752731037528654E081-34049
chr63752910937529340E081-33363
chr63752974437530325E081-32378
chr63753080737530912E081-31791
chr63753101337531077E081-31626
chr63753139037531436E081-31267
chr63753156437531661E081-31042
chr63753213237532182E081-30521
chr63753455637534741E081-27962
chr63753485237534976E081-27727
chr63753504737535167E081-27536
chr63753530337535354E081-27349
chr63753543537535546E081-27157
chr63753739437537463E081-25240
chr63753764637537947E081-24756
chr63754425937544525E081-18178
chr63755254237552736E081-9967
chr63755344637553531E081-9172
chr63755385837553974E081-8729
chr63755437137554416E081-8287
chr63755568237556076E081-6627
chr63755615237556402E081-6301
chr63755641937556531E081-6172
chr63755653737556658E081-6045
chr63755780037558042E081-4661
chr63755846237558522E081-4181
chr63758668237586725E08123979
chr63758673837586824E08124035
chr63758694437587318E08124241
chr63759196837592105E08129265
chr63759214137592279E08129438
chr63759640337596750E08133700
chr63760323637603453E08140533
chr63761015837610218E08147455
chr63751532637516107E082-46596
chr63751976537519969E082-42734
chr63752002237520212E082-42491
chr63752042137520471E082-42232
chr63752136837521757E082-40946
chr63752594337525993E082-36710
chr63752604537526302E082-36401
chr63752691837527006E082-35697
chr63752910937529340E082-33363
chr63753455637534741E082-27962
chr63755437137554416E082-8287
chr63755568237556076E082-6627
chr63755615237556402E082-6301
chr63755641937556531E082-6172
chr63755653737556658E082-6045
chr63755780037558042E082-4661
chr63758668237586725E08223979
chr63758673837586824E08224035
chr63758694437587318E08224241
chr63758753737587591E08224834
chr63759398037594030E08231277









Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr63752869837528764E067-33939
chr63752876737528859E067-33844
chr63753317737534494E067-28209
chr63752869837528764E068-33939
chr63752876737528859E068-33844
chr63753317737534494E068-28209
chr63753317737534494E069-28209
chr63753317737534494E070-28209
chr63752869837528764E071-33939
chr63752876737528859E071-33844
chr63752869837528764E072-33939
chr63752876737528859E072-33844
chr63753317737534494E072-28209
chr63753317737534494E073-28209
chr63752869837528764E074-33939
chr63753317737534494E074-28209
chr63752869837528764E081-33939
chr63752876737528859E081-33844
chr63753317737534494E082-28209