rs6464419

Homo sapiens
A>G
DPP6 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
A==0130 (3919/29952,GnomAD)
A==0154 (4485/29118,TOPMED)
A==0124 (620/5008,1000G)
A==0151 (583/3854,ALSPAC)
A==0161 (596/3708,TWINSUK)
chr7:154386240 (GRCh38.p7) (7q36.2)
ND
GWASdb2
1   publication(s)
See rs on genome
203 Enhancers around
16 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 7NC_000007.14:g.154386240A>G
GRCh37.p13 chr 7NC_000007.13:g.154083325A>G
DPP6 RefSeqGeneNG_033878.1:g.503907A>G

Gene: DPP6, dipeptidyl peptidase like 6(plus strand)

Molecule type Change Amino acid[Codon] SO Term
DPP6 transcript variant 3NM_001039350.2:c.N/AIntron Variant
DPP6 transcript variant 4NM_001290252.1:c.N/AIntron Variant
DPP6 transcript variant 5NM_001290253.1:c.N/AIntron Variant
DPP6 transcript variant 2NM_001936.4:c.N/AIntron Variant
DPP6 transcript variant 1NM_130797.3:c.N/AIntron Variant
DPP6 transcript variant X1XM_017011808.1:c.N/AIntron Variant
DPP6 transcript variant X2XM_017011809.1:c.N/AIntron Variant
DPP6 transcript variant X3XM_017011810.1:c.N/AIntron Variant
DPP6 transcript variant X4XM_017011811.1:c.N/AIntron Variant
DPP6 transcript variant X5XM_017011812.1:c.N/AGenic Upstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.166G=0.834
1000GenomesAmericanSub694A=0.120G=0.880
1000GenomesEast AsianSub1008A=0.010G=0.990
1000GenomesEuropeSub1006A=0.170G=0.830
1000GenomesGlobalStudy-wide5008A=0.124G=0.876
1000GenomesSouth AsianSub978A=0.140G=0.860
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.151G=0.849
The Genome Aggregation DatabaseAfricanSub8714A=0.148G=0.852
The Genome Aggregation DatabaseAmericanSub834A=0.110G=0.890
The Genome Aggregation DatabaseEast AsianSub1618A=0.004G=0.996
The Genome Aggregation DatabaseEuropeSub18484A=0.133G=0.866
The Genome Aggregation DatabaseGlobalStudy-wide29952A=0.130G=0.869
The Genome Aggregation DatabaseOtherSub302A=0.200G=0.800
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.154G=0.846
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.161G=0.839
PMID Title Author Journal
23542338A genomewide association study of smoking relapse in four European population-based samples.Tozzi FPsychiatr Genet

P-Value

SNP ID p-value Traits Study
rs64644198.11E-07nicotine dependence (smoking)23542338

eQTL of rs6464419 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs6464419 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr7154050378154050715E067-32610
chr7154050731154050877E067-32448
chr7154050921154051015E067-32310
chr7154051091154051141E067-32184
chr7154120248154120748E06736923
chr7154120795154120872E06737470
chr7154120987154121086E06737662
chr7154121258154121381E06737933
chr7154121445154121878E06738120
chr7154121927154122048E06738602
chr7154122121154122306E06738796
chr7154122483154122669E06739158
chr7154124766154125091E06741441
chr7154127321154127361E06743996
chr7154127449154127513E06744124
chr7154127723154127808E06744398
chr7154127910154127964E06744585
chr7154128192154128336E06744867
chr7154037288154037338E068-45987
chr7154037465154037547E068-45778
chr7154044254154044314E068-39011
chr7154044761154045193E068-38132
chr7154050378154050715E068-32610
chr7154050731154050877E068-32448
chr7154050921154051015E068-32310
chr7154051091154051141E068-32184
chr7154069212154069628E068-13697
chr7154069831154069928E068-13397
chr7154069969154070039E068-13286
chr7154073222154073348E068-9977
chr7154112587154112652E06829262
chr7154112807154113006E06829482
chr7154116092154116168E06832767
chr7154116248154116298E06832923
chr7154116502154116574E06833177
chr7154120248154120748E06836923
chr7154120795154120872E06837470
chr7154120987154121086E06837662
chr7154121258154121381E06837933
chr7154121445154121878E06838120
chr7154121927154122048E06838602
chr7154122121154122306E06838796
chr7154122483154122669E06839158
chr7154124766154125091E06841441
chr7154050378154050715E069-32610
chr7154050731154050877E069-32448
chr7154050921154051015E069-32310
chr7154051091154051141E069-32184
chr7154120248154120748E06936923
chr7154120795154120872E06937470
chr7154120987154121086E06937662
chr7154121258154121381E06937933
chr7154121445154121878E06938120
chr7154121927154122048E06938602
chr7154122121154122306E06938796
chr7154122483154122669E06939158
chr7154124766154125091E06941441
chr7154126634154126779E06943309
chr7154127321154127361E06943996
chr7154127449154127513E06944124
chr7154034614154034671E070-48654
chr7154034734154034784E070-48541
chr7154034931154035355E070-47970
chr7154035466154035560E070-47765
chr7154037288154037338E070-45987
chr7154037465154037547E070-45778
chr7154040069154040184E070-43141
chr7154044254154044314E070-39011
chr7154044761154045193E070-38132
chr7154045699154045753E070-37572
chr7154046100154046150E070-37175
chr7154048104154048226E070-35099
chr7154048453154048493E070-34832
chr7154048684154048761E070-34564
chr7154050378154050715E070-32610
chr7154050731154050877E070-32448
chr7154050921154051015E070-32310
chr7154051091154051141E070-32184
chr7154051293154051343E070-31982
chr7154073222154073348E070-9977
chr7154073516154073590E070-9735
chr7154073630154073823E070-9502
chr7154073897154073947E070-9378
chr7154095341154095502E07012016
chr7154120248154120748E07036923
chr7154120795154120872E07037470
chr7154120987154121086E07037662
chr7154121258154121381E07037933
chr7154121445154121878E07038120
chr7154121927154122048E07038602
chr7154122121154122306E07038796
chr7154122483154122669E07039158
chr7154124766154125091E07041441
chr7154034931154035355E071-47970
chr7154035466154035560E071-47765
chr7154044761154045193E071-38132
chr7154050731154050877E071-32448
chr7154050921154051015E071-32310
chr7154051091154051141E071-32184
chr7154051293154051343E071-31982
chr7154116248154116298E07132923
chr7154116502154116574E07133177
chr7154120248154120748E07136923
chr7154120795154120872E07137470
chr7154120987154121086E07137662
chr7154121258154121381E07137933
chr7154121445154121878E07138120
chr7154121927154122048E07138602
chr7154122121154122306E07138796
chr7154122483154122669E07139158
chr7154124766154125091E07141441
chr7154125924154125974E07142599
chr7154126634154126779E07143309
chr7154127321154127361E07143996
chr7154127449154127513E07144124
chr7154127723154127808E07144398
chr7154127910154127964E07144585
chr7154044761154045193E072-38132
chr7154050378154050715E072-32610
chr7154050731154050877E072-32448
chr7154050921154051015E072-32310
chr7154051091154051141E072-32184
chr7154120248154120748E07236923
chr7154120795154120872E07237470
chr7154120987154121086E07237662
chr7154121258154121381E07237933
chr7154126634154126779E07243309
chr7154127321154127361E07243996
chr7154127449154127513E07244124
chr7154127723154127808E07244398
chr7154127910154127964E07244585
chr7154128192154128336E07244867
chr7154116092154116168E07332767
chr7154120795154120872E07337470
chr7154120987154121086E07337662
chr7154121258154121381E07337933
chr7154121445154121878E07338120
chr7154035466154035560E074-47765
chr7154050378154050715E074-32610
chr7154050731154050877E074-32448
chr7154050921154051015E074-32310
chr7154051091154051141E074-32184
chr7154051293154051343E074-31982
chr7154112587154112652E07429262
chr7154112807154113006E07429482
chr7154116248154116298E07432923
chr7154116502154116574E07433177
chr7154120248154120748E07436923
chr7154120795154120872E07437470
chr7154120987154121086E07437662
chr7154121258154121381E07437933
chr7154121445154121878E07438120
chr7154121927154122048E07438602
chr7154122121154122306E07438796
chr7154122483154122669E07439158
chr7154124766154125091E07441441
chr7154125924154125974E07442599
chr7154126634154126779E07443309
chr7154127321154127361E07443996
chr7154127449154127513E07444124
chr7154127723154127808E07444398
chr7154127910154127964E07444585
chr7154128192154128336E07444867
chr7154129331154129388E07446006
chr7154034614154034671E081-48654
chr7154034734154034784E081-48541
chr7154034931154035355E081-47970
chr7154035466154035560E081-47765
chr7154037288154037338E081-45987
chr7154037465154037547E081-45778
chr7154037927154037997E081-45328
chr7154044254154044314E081-39011
chr7154044761154045193E081-38132
chr7154050378154050715E081-32610
chr7154050731154050877E081-32448
chr7154050921154051015E081-32310
chr7154051091154051141E081-32184
chr7154073056154073106E081-10219
chr7154095212154095305E08111887
chr7154095341154095502E08112016
chr7154121445154121878E08138120
chr7154121927154122048E08138602
chr7154122121154122306E08138796
chr7154122483154122669E08139158
chr7154124766154125091E08141441
chr7154035466154035560E082-47765
chr7154037288154037338E082-45987
chr7154037465154037547E082-45778
chr7154037927154037997E082-45328
chr7154044254154044314E082-39011
chr7154044761154045193E082-38132
chr7154050378154050715E082-32610
chr7154050731154050877E082-32448
chr7154050921154051015E082-32310
chr7154051091154051141E082-32184
chr7154051293154051343E082-31982
chr7154094626154094726E08211301
chr7154095212154095305E08211887
chr7154095341154095502E08212016
chr7154121445154121878E08238120
chr7154121927154122048E08238602
chr7154122121154122306E08238796
chr7154130837154130896E08247512










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr7154035626154036662E067-46663
chr7154036708154036950E067-46375
chr7154035626154036662E068-46663
chr7154036708154036950E068-46375
chr7154035626154036662E069-46663
chr7154036708154036950E069-46375
chr7154035626154036662E070-46663
chr7154035626154036662E071-46663
chr7154036708154036950E071-46375
chr7154035626154036662E072-46663
chr7154036708154036950E072-46375
chr7154035626154036662E073-46663
chr7154036708154036950E073-46375
chr7154035626154036662E074-46663
chr7154036708154036950E074-46375
chr7154035626154036662E082-46663