rs6465083

Homo sapiens
C>T
GRM3 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
T=0392 (11716/29874,GnomAD)
T=0466 (13578/29118,TOPMED)
T=0382 (1915/5008,1000G)
T=0263 (1012/3854,ALSPAC)
T=0276 (1024/3708,TWINSUK)
chr7:86732020 (GRCh38.p7) (7q21.12)
ND
GWASdb2
1   publication(s)
See rs on genome
348 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 7NC_000007.14:g.86732020C>T
GRCh37.p13 chr 7NC_000007.13:g.86361336C>T

Gene: GRM3, glutamate metabotropic receptor 3(plus strand)

Molecule type Change Amino acid[Codon] SO Term
GRM3 transcript variant 1NM_000840.2:c.N/AIntron Variant
GRM3 transcript variant X1XM_011516088.1:c.N/AIntron Variant
GRM3 transcript variant X2XM_017012073.1:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.270T=0.730
1000GenomesAmericanSub694C=0.740T=0.260
1000GenomesEast AsianSub1008C=0.769T=0.231
1000GenomesEuropeSub1006C=0.711T=0.289
1000GenomesGlobalStudy-wide5008C=0.618T=0.382
1000GenomesSouth AsianSub978C=0.750T=0.250
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.737T=0.263
The Genome Aggregation DatabaseAfricanSub8698C=0.342T=0.658
The Genome Aggregation DatabaseAmericanSub836C=0.760T=0.240
The Genome Aggregation DatabaseEast AsianSub1604C=0.794T=0.206
The Genome Aggregation DatabaseEuropeSub18434C=0.710T=0.289
The Genome Aggregation DatabaseGlobalStudy-wide29874C=0.607T=0.392
The Genome Aggregation DatabaseOtherSub302C=0.610T=0.390
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.533T=0.466
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.724T=0.276
PMID Title Author Journal
23542338A genomewide association study of smoking relapse in four European population-based samples.Tozzi FPsychiatr Genet

P-Value

SNP ID p-value Traits Study
rs64650833.97E-07nicotine dependence (smoking)23542338

eQTL of rs6465083 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs6465083 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr78632746386327709E067-33627
chr78632806186328226E067-33110
chr78632910686329197E067-32139
chr78633477686334850E067-26486
chr78633525886335355E067-25981
chr78633565786335751E067-25585
chr78633577586335841E067-25495
chr78633593286335997E067-25339
chr78633620886336487E067-24849
chr78633661886336759E067-24577
chr78633682486337035E067-24301
chr78633709586337172E067-24164
chr78633724986337315E067-24021
chr78633735186338175E067-23161
chr78633842886338485E067-22851
chr78633860286338668E067-22668
chr78633982186339871E067-21465
chr78634005386340113E067-21223
chr78634018786340237E067-21099
chr78634024786340343E067-20993
chr78634146586341580E067-19756
chr78634238486342434E067-18902
chr78634444686344496E067-16840
chr78634454986344599E067-16737
chr78634510186345151E067-16185
chr78634739686347446E067-13890
chr78634785486347955E067-13381
chr78635305886353168E067-8168
chr78637592986376043E06714593
chr78637607486376485E06714738
chr78637699386377033E06715657
chr78637709186377387E06715755
chr78637740886377894E06716072
chr78637806786378119E06716731
chr78637817386378245E06716837
chr78638037786380469E06719041
chr78638057186380621E06719235
chr78638092186380961E06719585
chr78638239786382441E06721061
chr78638942286389472E06728086
chr78639790886397978E06736572
chr78639811686398170E06736780
chr78639845986398515E06737123
chr78639876586398833E06737429
chr78639892186398988E06737585
chr78640511886405168E06743782
chr78640558386405709E06744247
chr78640578386405875E06744447
chr78640706786407117E06745731
chr78640716686407216E06745830
chr78640726086407310E06745924
chr78640775286407810E06746416
chr78640974286409864E06748406
chr78640991186409961E06748575
chr78641011786410167E06748781
chr78641023486410284E06748898
chr78632100686321056E068-40280
chr78632423586324371E068-36965
chr78632734586327403E068-33933
chr78632746386327709E068-33627
chr78632806186328226E068-33110
chr78633477686334850E068-26486
chr78633525886335355E068-25981
chr78633565786335751E068-25585
chr78633577586335841E068-25495
chr78633593286335997E068-25339
chr78633620886336487E068-24849
chr78633661886336759E068-24577
chr78633682486337035E068-24301
chr78633709586337172E068-24164
chr78633724986337315E068-24021
chr78633735186338175E068-23161
chr78633842886338485E068-22851
chr78634024786340343E068-20993
chr78634444686344496E068-16840
chr78634454986344599E068-16737
chr78634785486347955E068-13381
chr78635464886354698E068-6638
chr78635494386355035E068-6301
chr78636729986367349E0685963
chr78637592986376043E06814593
chr78637607486376485E06814738
chr78637740886377894E06816072
chr78637806786378119E06816731
chr78637817386378245E06816837
chr78637833386378449E06816997
chr78637859386379434E06817257
chr78638942286389472E06828086
chr78638970186389905E06828365
chr78639811686398170E06836780
chr78639845986398515E06837123
chr78639876586398833E06837429
chr78639892186398988E06837585
chr78640511886405168E06843782
chr78640558386405709E06844247
chr78640578386405875E06844447
chr78640599986406049E06844663
chr78640612286406202E06844786
chr78640622186406313E06844885
chr78640647186406545E06845135
chr78640706786407117E06845731
chr78640716686407216E06845830
chr78640726086407310E06845924
chr78640775286407810E06846416
chr78641011786410167E06848781
chr78641023486410284E06848898
chr78632404686324136E069-37200
chr78633477686334850E069-26486
chr78633525886335355E069-25981
chr78633565786335751E069-25585
chr78633577586335841E069-25495
chr78633593286335997E069-25339
chr78633620886336487E069-24849
chr78633661886336759E069-24577
chr78633682486337035E069-24301
chr78633709586337172E069-24164
chr78633724986337315E069-24021
chr78633735186338175E069-23161
chr78633842886338485E069-22851
chr78633860286338668E069-22668
chr78634146586341580E069-19756
chr78634238486342434E069-18902
chr78634265486342704E069-18632
chr78634785486347955E069-13381
chr78635305886353168E069-8168
chr78637377986374325E06912443
chr78637444086374649E06913104
chr78637592986376043E06914593
chr78637607486376485E06914738
chr78637699386377033E06915657
chr78637709186377387E06915755
chr78639160586391723E06930269
chr78639174286391828E06930406
chr78639202786392077E06930691
chr78639250086392571E06931164
chr78639259286392668E06931256
chr78639876586398833E06937429
chr78639892186398988E06937585
chr78640558386405709E06944247
chr78640578386405875E06944447
chr78640599986406049E06944663
chr78640612286406202E06944786
chr78640622186406313E06944885
chr78640647186406545E06945135
chr78640706786407117E06945731
chr78640716686407216E06945830
chr78640726086407310E06945924
chr78640775286407810E06946416
chr78641011786410167E06948781
chr78633577586335841E070-25495
chr78633593286335997E070-25339
chr78633620886336487E070-24849
chr78633661886336759E070-24577
chr78633682486337035E070-24301
chr78633709586337172E070-24164
chr78633724986337315E070-24021
chr78633735186338175E070-23161
chr78633842886338485E070-22851
chr78633860286338668E070-22668
chr78632100686321056E071-40280
chr78632734586327403E071-33933
chr78632746386327709E071-33627
chr78633477686334850E071-26486
chr78633525886335355E071-25981
chr78633565786335751E071-25585
chr78633577586335841E071-25495
chr78633593286335997E071-25339
chr78633620886336487E071-24849
chr78633661886336759E071-24577
chr78633682486337035E071-24301
chr78633709586337172E071-24164
chr78633724986337315E071-24021
chr78633735186338175E071-23161
chr78633842886338485E071-22851
chr78633860286338668E071-22668
chr78634018786340237E071-21099
chr78634024786340343E071-20993
chr78634739686347446E071-13890
chr78635305886353168E071-8168
chr78636314186363464E0711805
chr78636729986367349E0715963
chr78636753586367884E0716199
chr78637444086374649E07113104
chr78637468286374924E07113346
chr78637572186375811E07114385
chr78637592986376043E07114593
chr78637607486376485E07114738
chr78637699386377033E07115657
chr78637709186377387E07115755
chr78638455986384627E07123223
chr78638466986384729E07123333
chr78638490486384973E07123568
chr78639790886397978E07136572
chr78639811686398170E07136780
chr78639845986398515E07137123
chr78639876586398833E07137429
chr78639892186398988E07137585
chr78640706786407117E07145731
chr78640716686407216E07145830
chr78640726086407310E07145924
chr78640991186409961E07148575
chr78641011786410167E07148781
chr78641023486410284E07148898
chr78633565786335751E072-25585
chr78633577586335841E072-25495
chr78633593286335997E072-25339
chr78633620886336487E072-24849
chr78633661886336759E072-24577
chr78633682486337035E072-24301
chr78633709586337172E072-24164
chr78633724986337315E072-24021
chr78633735186338175E072-23161
chr78633842886338485E072-22851
chr78633860286338668E072-22668
chr78634265486342704E072-18632
chr78634648286346617E072-14719
chr78634671286346778E072-14558
chr78634739686347446E072-13890
chr78634785486347955E072-13381
chr78634982186349875E072-11461
chr78634997686350026E072-11310
chr78635016286350212E072-11124
chr78635026086350391E072-10945
chr78636729986367349E0725963
chr78637607486376485E07214738
chr78637699386377033E07215657
chr78637709186377387E07215755
chr78637740886377894E07216072
chr78637806786378119E07216731
chr78637817386378245E07216837
chr78637833386378449E07216997
chr78637859386379434E07217257
chr78638417986384229E07222843
chr78638426686384326E07222930
chr78638455986384627E07223223
chr78638466986384729E07223333
chr78638970186389905E07228365
chr78639845986398515E07237123
chr78639876586398833E07237429
chr78639892186398988E07237585
chr78640558386405709E07244247
chr78640578386405875E07244447
chr78640599986406049E07244663
chr78640612286406202E07244786
chr78640622186406313E07244885
chr78640647186406545E07245135
chr78633565786335751E073-25585
chr78633577586335841E073-25495
chr78633593286335997E073-25339
chr78633620886336487E073-24849
chr78633661886336759E073-24577
chr78633682486337035E073-24301
chr78633709586337172E073-24164
chr78633724986337315E073-24021
chr78633735186338175E073-23161
chr78633842886338485E073-22851
chr78633860286338668E073-22668
chr78636753586367884E0736199
chr78637833386378449E07316997
chr78638942286389472E07328086
chr78639250086392571E07331164
chr78639259286392668E07331256
chr78639271486392764E07331378
chr78640558386405709E07344247
chr78640578386405875E07344447
chr78631950586319555E074-41781
chr78631956086319600E074-41736
chr78632806186328226E074-33110
chr78633159686331650E074-29686
chr78633170786331765E074-29571
chr78633565786335751E074-25585
chr78633577586335841E074-25495
chr78633593286335997E074-25339
chr78633620886336487E074-24849
chr78633661886336759E074-24577
chr78633682486337035E074-24301
chr78633709586337172E074-24164
chr78633724986337315E074-24021
chr78633735186338175E074-23161
chr78633842886338485E074-22851
chr78633860286338668E074-22668
chr78634238486342434E074-18902
chr78634265486342704E074-18632
chr78634739686347446E074-13890
chr78634785486347955E074-13381
chr78634982186349875E074-11461
chr78634997686350026E074-11310
chr78635016286350212E074-11124
chr78635026086350391E074-10945
chr78636729986367349E0745963
chr78637377986374325E07412443
chr78637444086374649E07413104
chr78637572186375811E07414385
chr78637592986376043E07414593
chr78637607486376485E07414738
chr78637699386377033E07415657
chr78637709186377387E07415755
chr78637859386379434E07417257
chr78637949386379549E07418157
chr78637957386380227E07418237
chr78638037786380469E07419041
chr78638057186380621E07419235
chr78638092186380961E07419585
chr78638417986384229E07422843
chr78638426686384326E07422930
chr78638455986384627E07423223
chr78639259286392668E07431256
chr78639271486392764E07431378
chr78639285986392909E07431523
chr78639324686393309E07431910
chr78639335986393433E07432023
chr78639845986398515E07437123
chr78639876586398833E07437429
chr78639892186398988E07437585
chr78640558386405709E07444247
chr78640578386405875E07444447
chr78640599986406049E07444663
chr78640612286406202E07444786
chr78640622186406313E07444885
chr78640647186406545E07445135
chr78640706786407117E07445731
chr78640716686407216E07445830
chr78640726086407310E07445924
chr78640775286407810E07446416
chr78633477686334850E081-26486
chr78633565786335751E081-25585
chr78633577586335841E081-25495
chr78633593286335997E081-25339
chr78633682486337035E081-24301
chr78633709586337172E081-24164
chr78633724986337315E081-24021
chr78633735186338175E081-23161
chr78633842886338485E081-22851
chr78637699386377033E08115657
chr78637709186377387E08115755
chr78637740886377894E08116072
chr78637806786378119E08116731
chr78637817386378245E08116837
chr78637833386378449E08116997
chr78637859386379434E08117257
chr78637957386380227E08118237
chr78638037786380469E08119041
chr78638057186380621E08119235
chr78633565786335751E082-25585
chr78633577586335841E082-25495
chr78633593286335997E082-25339
chr78637709186377387E08215755
chr78637949386379549E08218157