rs6466086

Homo sapiens
A>G
None
Check p-value
SNV (Single Nucleotide Variation)
G=0236 (7076/29974,GnomAD)
G=0309 (9013/29118,TOPMED)
G=0333 (1667/5008,1000G)
G=0088 (338/3854,ALSPAC)
G=0082 (305/3708,TWINSUK)
chr7:106122980 (GRCh38.p7) (7q22.3)
AD
GWASdb2
1   publication(s)
See rs on genome
138 Enhancers around
17 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 7NC_000007.14:g.106122980A>G
GRCh37.p13 chr 7NC_000007.13:g.105763426A>G

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.322G=0.678
1000GenomesAmericanSub694A=0.660G=0.340
1000GenomesEast AsianSub1008A=0.735G=0.265
1000GenomesEuropeSub1006A=0.919G=0.081
1000GenomesGlobalStudy-wide5008A=0.667G=0.333
1000GenomesSouth AsianSub978A=0.810G=0.190
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.912G=0.088
The Genome Aggregation DatabaseAfricanSub8714A=0.423G=0.577
The Genome Aggregation DatabaseAmericanSub838A=0.650G=0.350
The Genome Aggregation DatabaseEast AsianSub1618A=0.755G=0.245
The Genome Aggregation DatabaseEuropeSub18502A=0.928G=0.071
The Genome Aggregation DatabaseGlobalStudy-wide29974A=0.763G=0.236
The Genome Aggregation DatabaseOtherSub302A=0.890G=0.110
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.690G=0.309
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.918G=0.082
PMID Title Author Journal
22481050Genetic influences on craving for alcohol.Agrawal AAddict Behav

P-Value

SNP ID p-value Traits Study
rs64660861.26E-05alcohol craving with or without dependence22481050

eQTL of rs6466086 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs6466086 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr7105720785105721066E067-42360
chr7105741056105741213E067-22213
chr7105741240105741354E067-22072
chr7105741381105741550E067-21876
chr7105741681105741729E067-21697
chr7105741863105741945E067-21481
chr7105742278105742520E067-20906
chr7105742915105743114E067-20312
chr7105743168105743234E067-20192
chr7105743326105743439E067-19987
chr7105749348105749418E067-14008
chr7105749532105749814E067-13612
chr7105749870105750208E067-13218
chr7105780869105781170E06717443
chr7105807194105807735E06743768
chr7105807821105808003E06744395
chr7105808006105808177E06744580
chr7105808304105808379E06744878
chr7105808595105808723E06745169
chr7105741056105741213E068-22213
chr7105741240105741354E068-22072
chr7105741381105741550E068-21876
chr7105741681105741729E068-21697
chr7105749348105749418E068-14008
chr7105749532105749814E068-13612
chr7105749870105750208E068-13218
chr7105720785105721066E069-42360
chr7105745928105746028E069-17398
chr7105748878105748944E069-14482
chr7105748950105749160E069-14266
chr7105749348105749418E069-14008
chr7105749532105749814E069-13612
chr7105749870105750208E069-13218
chr7105749348105749418E070-14008
chr7105749532105749814E070-13612
chr7105749870105750208E070-13218
chr7105740981105741031E071-22395
chr7105741056105741213E071-22213
chr7105741240105741354E071-22072
chr7105741381105741550E071-21876
chr7105741681105741729E071-21697
chr7105745787105745906E071-17520
chr7105745928105746028E071-17398
chr7105748878105748944E071-14482
chr7105748950105749160E071-14266
chr7105749348105749418E071-14008
chr7105749532105749814E071-13612
chr7105749870105750208E071-13218
chr7105793319105793554E07129893
chr7105793609105793637E07130183
chr7105793644105793970E07130218
chr7105794135105794688E07130709
chr7105745928105746028E073-17398
chr7105749870105750208E073-13218
chr7105779824105780753E07316398
chr7105780869105781170E07317443
chr7105793319105793554E07329893
chr7105793609105793637E07330183
chr7105793644105793970E07330218
chr7105716887105716952E074-46474
chr7105720785105721066E074-42360
chr7105743168105743234E074-20192
chr7105743326105743439E074-19987
chr7105744515105744555E074-18871
chr7105745488105745661E074-17765
chr7105745787105745906E074-17520
chr7105745928105746028E074-17398
chr7105749348105749418E074-14008
chr7105749532105749814E074-13612
chr7105749870105750208E074-13218
chr7105762517105762567E074-859
chr7105713613105713671E081-49755
chr7105713768105713877E081-49549
chr7105713956105713996E081-49430
chr7105714115105714169E081-49257
chr7105714277105714452E081-48974
chr7105714649105714863E081-48563
chr7105714910105715139E081-48287
chr7105715175105715531E081-47895
chr7105716355105716726E081-46700
chr7105716887105716952E081-46474
chr7105741681105741729E081-21697
chr7105741863105741945E081-21481
chr7105748878105748944E081-14482
chr7105748950105749160E081-14266
chr7105749348105749418E081-14008
chr7105749532105749814E081-13612
chr7105749870105750208E081-13218
chr7105779540105779610E08116114
chr7105779651105779691E08116225
chr7105779824105780753E08116398
chr7105780869105781170E08117443
chr7105781301105781579E08117875
chr7105792814105792889E08129388
chr7105792974105793055E08129548
chr7105793180105793300E08129754
chr7105793319105793554E08129893
chr7105793609105793637E08130183
chr7105793644105793970E08130218
chr7105794135105794688E08130709
chr7105794827105795127E08131401
chr7105795144105795238E08131718
chr7105795285105795546E08131859
chr7105796059105796145E08132633
chr7105796226105796378E08132800
chr7105804761105804882E08141335
chr7105804958105805192E08141532
chr7105810218105810748E08146792
chr7105713613105713671E082-49755
chr7105713768105713877E082-49549
chr7105713956105713996E082-49430
chr7105714115105714169E082-49257
chr7105714277105714452E082-48974
chr7105714649105714863E082-48563
chr7105714910105715139E082-48287
chr7105715175105715531E082-47895
chr7105716355105716726E082-46700
chr7105716887105716952E082-46474
chr7105745488105745661E082-17765
chr7105745787105745906E082-17520
chr7105762267105762507E082-919
chr7105762517105762567E082-859
chr7105779540105779610E08216114
chr7105779651105779691E08216225
chr7105779824105780753E08216398
chr7105780869105781170E08217443
chr7105792814105792889E08229388
chr7105792974105793055E08229548
chr7105793180105793300E08229754
chr7105793319105793554E08229893
chr7105793609105793637E08230183
chr7105793644105793970E08230218
chr7105794827105795127E08231401
chr7105795144105795238E08231718
chr7105795285105795546E08231859
chr7105809821105809871E08246395
chr7105809912105809952E08246486
chr7105810218105810748E08246792









Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr7105751216105751296E067-12130
chr7105751330105754007E067-9419
chr7105751216105751296E068-12130
chr7105751330105754007E068-9419
chr7105751330105754007E069-9419
chr7105751330105754007E070-9419
chr7105751330105754007E071-9419
chr7105751216105751296E072-12130
chr7105751330105754007E072-9419
chr7105751216105751296E073-12130
chr7105751330105754007E073-9419
chr7105751216105751296E074-12130
chr7105751330105754007E074-9419
chr7105751216105751296E081-12130
chr7105751330105754007E081-9419
chr7105751216105751296E082-12130
chr7105751330105754007E082-9419