rs646667

Homo sapiens
T>C
SESN3 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
C=0079 (2364/29928,GnomAD)
C=0098 (2873/29118,TOPMED)
C=0157 (788/5008,1000G)
C=0025 (97/3854,ALSPAC)
C=0022 (82/3708,TWINSUK)
chr11:95182814 (GRCh38.p7) (11q21)
AD
GWASdb2
1   publication(s)
See rs on genome
126 Enhancers around
22 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 11NC_000011.10:g.95182814T>C
GRCh37.p13 chr 11NC_000011.9:g.94915978T>C

Gene: SESN3, sestrin 3(minus strand)

Molecule type Change Amino acid[Codon] SO Term
SESN3 transcript variant 2NM_001271594.1:c.N/AIntron Variant
SESN3 transcript variant 1NM_144665.3:c.N/AIntron Variant
SESN3 transcript variant X1XM_011542614.1:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.825C=0.175
1000GenomesAmericanSub694T=0.920C=0.080
1000GenomesEast AsianSub1008T=0.688C=0.312
1000GenomesEuropeSub1006T=0.984C=0.016
1000GenomesGlobalStudy-wide5008T=0.843C=0.157
1000GenomesSouth AsianSub978T=0.830C=0.170
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.975C=0.025
The Genome Aggregation DatabaseAfricanSub8706T=0.846C=0.154
The Genome Aggregation DatabaseAmericanSub834T=0.940C=0.060
The Genome Aggregation DatabaseEast AsianSub1600T=0.723C=0.278
The Genome Aggregation DatabaseEuropeSub18486T=0.971C=0.028
The Genome Aggregation DatabaseGlobalStudy-wide29928T=0.921C=0.079
The Genome Aggregation DatabaseOtherSub302T=0.980C=0.020
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.901C=0.098
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.978C=0.022
PMID Title Author Journal
24277619ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.Quillen EEAm J Med Genet B Neuropsychiatr Genet

P-Value

SNP ID p-value Traits Study
rs6466670.000338alcohol consumption (maxi-drinks)24277619

eQTL of rs646667 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs646667 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr119486605594866759E067-49219
chr119486748894868437E067-47541
chr119486847694868585E067-47393
chr119487361094873824E067-42154
chr119487398594874162E067-41816
chr119487418894874349E067-41629
chr119487566994875850E067-40128
chr119488047794881189E067-34789
chr119488145894881976E067-34002
chr119488220594882259E067-33719
chr119488230394882532E067-33446
chr119488738894887475E067-28503
chr119491565494915780E067-198
chr119491589894915977E067-1
chr119491736894917491E0671390
chr119491770894917941E0671730
chr119495903794959090E06743059
chr119495910994959159E06743131
chr119486605594866759E068-49219
chr119486714694867318E068-48660
chr119486748894868437E068-47541
chr119486847694868585E068-47393
chr119488011994880343E068-35635
chr119488035594880466E068-35512
chr119488047794881189E068-34789
chr119488145894881976E068-34002
chr119488985194890075E068-25903
chr119489012394891025E068-24953
chr119489106294891240E068-24738
chr119489138294891540E068-24438
chr119489162794891690E068-24288
chr119493127394931323E06815295
chr119494351694943625E06827538
chr119494367494943782E06827696
chr119494435694944572E06828378
chr119486605594866759E069-49219
chr119486714694867318E069-48660
chr119486748894868437E069-47541
chr119486847694868585E069-47393
chr119487361094873824E069-42154
chr119487398594874162E069-41816
chr119487418894874349E069-41629
chr119487471794874783E069-41195
chr119487638094876539E069-39439
chr119487793094878045E069-37933
chr119487809594878328E069-37650
chr119487838094878510E069-37468
chr119487868994878805E069-37173
chr119487896294879057E069-36921
chr119488047794881189E069-34789
chr119488145894881976E069-34002
chr119488220594882259E069-33719
chr119488230394882532E069-33446
chr119492624494926296E06910266
chr119492453894924721E0708560
chr119494646994946535E07030491
chr119486605594866759E071-49219
chr119486748894868437E071-47541
chr119486847694868585E071-47393
chr119487341494873477E071-42501
chr119487361094873824E071-42154
chr119487398594874162E071-41816
chr119487418894874349E071-41629
chr119487471794874783E071-41195
chr119487515194875333E071-40645
chr119487980294879925E071-36053
chr119488011994880343E071-35635
chr119488035594880466E071-35512
chr119488047794881189E071-34789
chr119488145894881976E071-34002
chr119488220594882259E071-33719
chr119488230394882532E071-33446
chr119493112494931232E07115146
chr119493127394931323E07115295
chr119486605594866759E072-49219
chr119486714694867318E072-48660
chr119486748894868437E072-47541
chr119486847694868585E072-47393
chr119486913394869183E072-46795
chr119487361094873824E072-42154
chr119487398594874162E072-41816
chr119487418894874349E072-41629
chr119487536694875474E072-40504
chr119487566994875850E072-40128
chr119488011994880343E072-35635
chr119488035594880466E072-35512
chr119488047794881189E072-34789
chr119488145894881976E072-34002
chr119488220594882259E072-33719
chr119488230394882532E072-33446
chr119492624494926296E07210266
chr119492686994926972E07210891
chr119492724294927286E07211264
chr119494351694943625E07227538
chr119494367494943782E07227696
chr119494435694944572E07228378
chr119496082694960876E07244848
chr119496092594960975E07244947
chr119486748894868437E073-47541
chr119487566994875850E073-40128
chr119488035594880466E073-35512
chr119488047794881189E073-34789
chr119488145894881976E073-34002
chr119489012394891025E073-24953
chr119489106294891240E073-24738
chr119492986594929942E07313887
chr119493017794930287E07314199
chr119493039194930441E07314413
chr119486605594866759E074-49219
chr119486714694867318E074-48660
chr119486748894868437E074-47541
chr119486847694868585E074-47393
chr119487361094873824E074-42154
chr119487398594874162E074-41816
chr119487418894874349E074-41629
chr119487566994875850E074-40128
chr119487980294879925E074-36053
chr119488011994880343E074-35635
chr119488035594880466E074-35512
chr119488047794881189E074-34789
chr119488145894881976E074-34002
chr119488220594882259E074-33719
chr119488230394882532E074-33446
chr119496082694960876E07444848
chr119496092594960975E07444947
chr119496121794961273E07445239








Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr119488273494885508E067-30470
chr119496205994962166E06746081
chr119488273494885508E068-30470
chr119496137194962034E06845393
chr119496205994962166E06846081
chr119488273494885508E069-30470
chr119496137194962034E06945393
chr119496205994962166E06946081
chr119496137194962034E07045393
chr119496205994962166E07046081
chr119488273494885508E071-30470
chr119496205994962166E07146081
chr119488273494885508E072-30470
chr119496137194962034E07245393
chr119496205994962166E07246081
chr119488273494885508E073-30470
chr119496137194962034E07345393
chr119496205994962166E07346081
chr119488273494885508E074-30470
chr119488273494885508E082-30470
chr119496137194962034E08245393
chr119496205994962166E08246081