rs6473308

Homo sapiens
G>A
None
Check p-value
SNV (Single Nucleotide Variation)
G==0343 (10287/29938,GnomAD)
G==0360 (10502/29118,TOPMED)
G==0397 (1987/5008,1000G)
G==0333 (1282/3854,ALSPAC)
G==0321 (1190/3708,TWINSUK)
chr8:81795473 (GRCh38.p7) (8q21.13)
AD
GWASdb2
1   publication(s)
See rs on genome
93 Enhancers around
39 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 8NC_000008.11:g.81795473G>A
GRCh37.p13 chr 8NC_000008.10:g.82707708G>A

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.376A=0.624
1000GenomesAmericanSub694G=0.390A=0.610
1000GenomesEast AsianSub1008G=0.597A=0.403
1000GenomesEuropeSub1006G=0.327A=0.673
1000GenomesGlobalStudy-wide5008G=0.397A=0.603
1000GenomesSouth AsianSub978G=0.290A=0.710
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.333A=0.667
The Genome Aggregation DatabaseAfricanSub8704G=0.368A=0.632
The Genome Aggregation DatabaseAmericanSub836G=0.320A=0.680
The Genome Aggregation DatabaseEast AsianSub1616G=0.631A=0.369
The Genome Aggregation DatabaseEuropeSub18480G=0.307A=0.692
The Genome Aggregation DatabaseGlobalStudy-wide29938G=0.343A=0.656
The Genome Aggregation DatabaseOtherSub302G=0.370A=0.630
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.360A=0.639
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.321A=0.679
PMID Title Author Journal
23743675A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks.Kapoor MHum Genet

P-Value

SNP ID p-value Traits Study
rs64733083.66E-05alcohol consumption23743675

eQTL of rs6473308 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs6473308 in Fetal Brain

Probe ID Position Gene beta p-value
cg17211192chr8:82754475SNX160.06507179835992783.6150e-27
cg27398817chr8:82754497SNX160.03859704753286651.9163e-15
cg23324259chr8:82754387SNX160.01760097898047476.9527e-14

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr88272692182727044E06719213
chr88272708482727145E06719376
chr88272739782727713E06719689
chr88275141582751459E06743707
chr88275155182751632E06743843
chr88275169382751743E06743985
chr88275176982751905E06744061
chr88275192082751978E06744212
chr88275205182752101E06744343
chr88275213682752286E06744428
chr88275242482752500E06744716
chr88275252382752586E06744815
chr88274913582749745E06841427
chr88275040382750493E06842695
chr88275055782750622E06842849
chr88275073382750913E06843025
chr88275118682751259E06843478
chr88275141582751459E06843707
chr88275155182751632E06843843
chr88275169382751743E06843985
chr88275242482752500E06844716
chr88275252382752586E06844815
chr88275264882752702E06844940
chr88275205182752101E06944343
chr88275213682752286E06944428
chr88275242482752500E06944716
chr88275252382752586E06944815
chr88275264882752702E06944940
chr88270876682709232E0701058
chr88270927582709325E0701567
chr88270935482709440E0701646
chr88273635982736422E07028651
chr88273760682737656E07029898
chr88273770482737783E07029996
chr88274913582749745E07041427
chr88272692182727044E07119213
chr88272739782727713E07119689
chr88275040382750493E07142695
chr88275055782750622E07142849
chr88275073382750913E07143025
chr88275176982751905E07144061
chr88275192082751978E07144212
chr88275205182752101E07144343
chr88275213682752286E07144428
chr88275242482752500E07144716
chr88275252382752586E07144815
chr88275264882752702E07144940
chr88269268482693377E072-14331
chr88272629482726439E07218586
chr88272692182727044E07219213
chr88272708482727145E07219376
chr88272739782727713E07219689
chr88272739782727713E07319689
chr88272692182727044E07419213
chr88275040382750493E07442695
chr88275055782750622E07442849
chr88275073382750913E07443025
chr88275118682751259E07443478
chr88275141582751459E07443707
chr88275155182751632E07443843
chr88275169382751743E07443985
chr88275176982751905E07444061
chr88275192082751978E07444212
chr88275205182752101E07444343
chr88275213682752286E07444428
chr88275242482752500E07444716
chr88275252382752586E07444815
chr88275264882752702E07444940
chr88269268482693377E081-14331
chr88274894182748991E08141233
chr88275118682751259E08143478
chr88275141582751459E08143707
chr88275155182751632E08143843
chr88275169382751743E08143985
chr88275176982751905E08144061
chr88275192082751978E08144212
chr88275205182752101E08144343
chr88275213682752286E08144428
chr88275242482752500E08144716
chr88275252382752586E08144815
chr88275264882752702E08144940
chr88269939382699447E082-8261
chr88269957982699654E082-8054
chr88274913582749745E08241427
chr88274982582749873E08242117
chr88275155182751632E08243843
chr88275169382751743E08243985
chr88275176982751905E08244061
chr88275192082751978E08244212
chr88275205182752101E08244343
chr88275213682752286E08244428
chr88275242482752500E08244716
chr88275252382752586E08244815










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr88275290282753069E06745194
chr88275314082753307E06745432
chr88275349982753591E06745791
chr88275360282754599E06745894
chr88275349982753591E06845791
chr88275360282754599E06845894
chr88275461982755486E06846911
chr88275290282753069E06945194
chr88275314082753307E06945432
chr88275349982753591E06945791
chr88275360282754599E06945894
chr88275290282753069E07045194
chr88275314082753307E07045432
chr88275349982753591E07045791
chr88275360282754599E07045894
chr88275290282753069E07145194
chr88275314082753307E07145432
chr88275349982753591E07145791
chr88275360282754599E07145894
chr88275461982755486E07146911
chr88275290282753069E07245194
chr88275314082753307E07245432
chr88275349982753591E07245791
chr88275360282754599E07245894
chr88275290282753069E07345194
chr88275314082753307E07345432
chr88275349982753591E07345791
chr88275360282754599E07345894
chr88275461982755486E07346911
chr88275314082753307E07445432
chr88275349982753591E07445791
chr88275360282754599E07445894
chr88275461982755486E07446911
chr88275360282754599E08145894
chr88275290282753069E08245194
chr88275314082753307E08245432
chr88275349982753591E08245791
chr88275360282754599E08245894
chr88275461982755486E08246911