rs6473309

Homo sapiens
A>G
None
Check p-value
SNV (Single Nucleotide Variation)
A==0343 (10275/29910,GnomAD)
A==0360 (10502/29118,TOPMED)
A==0397 (1987/5008,1000G)
A==0333 (1282/3854,ALSPAC)
A==0320 (1188/3708,TWINSUK)
chr8:81795645 (GRCh38.p7) (8q21.13)
AD
GWASdb2
1   publication(s)
See rs on genome
93 Enhancers around
39 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 8NC_000008.11:g.81795645A>G
GRCh37.p13 chr 8NC_000008.10:g.82707880A>G

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.376G=0.624
1000GenomesAmericanSub694A=0.390G=0.610
1000GenomesEast AsianSub1008A=0.597G=0.403
1000GenomesEuropeSub1006A=0.327G=0.673
1000GenomesGlobalStudy-wide5008A=0.397G=0.603
1000GenomesSouth AsianSub978A=0.290G=0.710
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.333G=0.667
The Genome Aggregation DatabaseAfricanSub8700A=0.368G=0.632
The Genome Aggregation DatabaseAmericanSub838A=0.320G=0.680
The Genome Aggregation DatabaseEast AsianSub1614A=0.629G=0.371
The Genome Aggregation DatabaseEuropeSub18456A=0.307G=0.692
The Genome Aggregation DatabaseGlobalStudy-wide29910A=0.343G=0.656
The Genome Aggregation DatabaseOtherSub302A=0.370G=0.630
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.360G=0.639
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.320G=0.680
PMID Title Author Journal
23743675A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks.Kapoor MHum Genet

P-Value

SNP ID p-value Traits Study
rs64733093.54E-05alcohol consumption23743675

eQTL of rs6473309 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs6473309 in Fetal Brain

Probe ID Position Gene beta p-value
cg17211192chr8:82754475SNX160.06507179835992783.6150e-27
cg27398817chr8:82754497SNX160.03859704753286651.9163e-15
cg23324259chr8:82754387SNX160.01760097898047476.9527e-14

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr88272692182727044E06719041
chr88272708482727145E06719204
chr88272739782727713E06719517
chr88275141582751459E06743535
chr88275155182751632E06743671
chr88275169382751743E06743813
chr88275176982751905E06743889
chr88275192082751978E06744040
chr88275205182752101E06744171
chr88275213682752286E06744256
chr88275242482752500E06744544
chr88275252382752586E06744643
chr88274913582749745E06841255
chr88275040382750493E06842523
chr88275055782750622E06842677
chr88275073382750913E06842853
chr88275118682751259E06843306
chr88275141582751459E06843535
chr88275155182751632E06843671
chr88275169382751743E06843813
chr88275242482752500E06844544
chr88275252382752586E06844643
chr88275264882752702E06844768
chr88275205182752101E06944171
chr88275213682752286E06944256
chr88275242482752500E06944544
chr88275252382752586E06944643
chr88275264882752702E06944768
chr88270876682709232E070886
chr88270927582709325E0701395
chr88270935482709440E0701474
chr88273635982736422E07028479
chr88273760682737656E07029726
chr88273770482737783E07029824
chr88274913582749745E07041255
chr88272692182727044E07119041
chr88272739782727713E07119517
chr88275040382750493E07142523
chr88275055782750622E07142677
chr88275073382750913E07142853
chr88275176982751905E07143889
chr88275192082751978E07144040
chr88275205182752101E07144171
chr88275213682752286E07144256
chr88275242482752500E07144544
chr88275252382752586E07144643
chr88275264882752702E07144768
chr88269268482693377E072-14503
chr88272629482726439E07218414
chr88272692182727044E07219041
chr88272708482727145E07219204
chr88272739782727713E07219517
chr88272739782727713E07319517
chr88272692182727044E07419041
chr88275040382750493E07442523
chr88275055782750622E07442677
chr88275073382750913E07442853
chr88275118682751259E07443306
chr88275141582751459E07443535
chr88275155182751632E07443671
chr88275169382751743E07443813
chr88275176982751905E07443889
chr88275192082751978E07444040
chr88275205182752101E07444171
chr88275213682752286E07444256
chr88275242482752500E07444544
chr88275252382752586E07444643
chr88275264882752702E07444768
chr88269268482693377E081-14503
chr88274894182748991E08141061
chr88275118682751259E08143306
chr88275141582751459E08143535
chr88275155182751632E08143671
chr88275169382751743E08143813
chr88275176982751905E08143889
chr88275192082751978E08144040
chr88275205182752101E08144171
chr88275213682752286E08144256
chr88275242482752500E08144544
chr88275252382752586E08144643
chr88275264882752702E08144768
chr88269939382699447E082-8433
chr88269957982699654E082-8226
chr88274913582749745E08241255
chr88274982582749873E08241945
chr88275155182751632E08243671
chr88275169382751743E08243813
chr88275176982751905E08243889
chr88275192082751978E08244040
chr88275205182752101E08244171
chr88275213682752286E08244256
chr88275242482752500E08244544
chr88275252382752586E08244643










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr88275290282753069E06745022
chr88275314082753307E06745260
chr88275349982753591E06745619
chr88275360282754599E06745722
chr88275349982753591E06845619
chr88275360282754599E06845722
chr88275461982755486E06846739
chr88275290282753069E06945022
chr88275314082753307E06945260
chr88275349982753591E06945619
chr88275360282754599E06945722
chr88275290282753069E07045022
chr88275314082753307E07045260
chr88275349982753591E07045619
chr88275360282754599E07045722
chr88275290282753069E07145022
chr88275314082753307E07145260
chr88275349982753591E07145619
chr88275360282754599E07145722
chr88275461982755486E07146739
chr88275290282753069E07245022
chr88275314082753307E07245260
chr88275349982753591E07245619
chr88275360282754599E07245722
chr88275290282753069E07345022
chr88275314082753307E07345260
chr88275349982753591E07345619
chr88275360282754599E07345722
chr88275461982755486E07346739
chr88275314082753307E07445260
chr88275349982753591E07445619
chr88275360282754599E07445722
chr88275461982755486E07446739
chr88275360282754599E08145722
chr88275290282753069E08245022
chr88275314082753307E08245260
chr88275349982753591E08245619
chr88275360282754599E08245722
chr88275461982755486E08246739