rs6474300

Homo sapiens
A>G
None
Check p-value
SNV (Single Nucleotide Variation)
G=0198 (5944/29940,GnomAD)
G=0221 (6442/29118,TOPMED)
G=0172 (859/5008,1000G)
G=0195 (752/3854,ALSPAC)
G=0199 (737/3708,TWINSUK)
chr8:41108162 (GRCh38.p7) (8p11.21)
AD
GWASdb2
1   publication(s)
See rs on genome
86 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 8NC_000008.11:g.41108162A>G
GRCh37.p13 chr 8NC_000008.10:g.40965681A>G

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.720G=0.280
1000GenomesAmericanSub694A=0.810G=0.190
1000GenomesEast AsianSub1008A=0.953G=0.047
1000GenomesEuropeSub1006A=0.810G=0.190
1000GenomesGlobalStudy-wide5008A=0.828G=0.172
1000GenomesSouth AsianSub978A=0.880G=0.120
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.805G=0.195
The Genome Aggregation DatabaseAfricanSub8706A=0.732G=0.268
The Genome Aggregation DatabaseAmericanSub836A=0.830G=0.170
The Genome Aggregation DatabaseEast AsianSub1620A=0.957G=0.043
The Genome Aggregation DatabaseEuropeSub18476A=0.818G=0.181
The Genome Aggregation DatabaseGlobalStudy-wide29940A=0.801G=0.198
The Genome Aggregation DatabaseOtherSub302A=0.840G=0.160
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.778G=0.221
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.801G=0.199
PMID Title Author Journal
21703634A meta-analysis of two genome-wide association studies identifies 3 new loci for alcohol dependence.Wang KSJ Psychiatr Res

P-Value

SNP ID p-value Traits Study
rs64743004.38E-05alcohol dependence21703634

eQTL of rs6474300 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs6474300 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr84095664640956823E067-8858
chr84095693340956983E067-8698
chr84095843640959066E067-6615
chr84095637340956547E068-9134
chr84095664640956823E068-8858
chr84095693340956983E068-8698
chr84095787740958229E068-7452
chr84095843640959066E068-6615
chr84098310640983258E06817425
chr84098334640983565E06817665
chr84098356640983966E06817885
chr84095637340956547E069-9134
chr84095664640956823E069-8858
chr84095693340956983E069-8698
chr84095713640957193E069-8488
chr84095728840957389E069-8292
chr84095787740958229E069-7452
chr84095843640959066E069-6615
chr84098356640983966E06917885
chr84100364241004576E06937961
chr84101453841014650E06948857
chr84101479941014926E06949118
chr84101496541015191E06949284
chr84101520341015290E06949522
chr84093498740935164E070-30517
chr84093525540935870E070-29811
chr84093612640936318E070-29363
chr84093634140936403E070-29278
chr84093649640936624E070-29057
chr84093688640937001E070-28680
chr84093751340937563E070-28118
chr84095637340956547E071-9134
chr84095664640956823E071-8858
chr84095693340956983E071-8698
chr84095713640957193E071-8488
chr84095728840957389E071-8292
chr84095787740958229E071-7452
chr84095843640959066E071-6615
chr84095920640959298E071-6383
chr84095956740959617E071-6064
chr84097344940973538E0717768
chr84097360040973654E0717919
chr84097374640973915E0718065
chr84098310640983258E07117425
chr84098334640983565E07117665
chr84098356640983966E07117885
chr84101453841014650E07148857
chr84101479941014926E07149118
chr84101496541015191E07149284
chr84101520341015290E07149522
chr84094104740941097E072-24584
chr84094110140941225E072-24456
chr84095664640956823E072-8858
chr84095693340956983E072-8698
chr84095713640957193E072-8488
chr84095728840957389E072-8292
chr84095787740958229E072-7452
chr84095843640959066E072-6615
chr84095664640956823E073-8858
chr84095693340956983E073-8698
chr84095713640957193E073-8488
chr84095728840957389E073-8292
chr84095637340956547E074-9134
chr84095664640956823E074-8858
chr84095693340956983E074-8698
chr84095713640957193E074-8488
chr84095728840957389E074-8292
chr84095787740958229E074-7452
chr84095843640959066E074-6615
chr84095920640959298E074-6383
chr84095956740959617E074-6064
chr84096011640960263E074-5418
chr84096026440960595E074-5086
chr84100364241004576E07437961
chr84101479941014926E07449118
chr84101496541015191E07449284
chr84101520341015290E07449522
chr84095637340956547E081-9134
chr84095664640956823E081-8858
chr84095693340956983E081-8698
chr84093498740935164E082-30517
chr84093525540935870E082-29811
chr84093612640936318E082-29363
chr84093634140936403E082-29278
chr84093649640936624E082-29057
chr84093751340937563E082-28118