rs6496267

Homo sapiens
G>A
None
Check p-value
SNV (Single Nucleotide Variation)
G==0351 (10501/29918,GnomAD)
G==0341 (9951/29118,TOPMED)
G==0409 (2048/5008,1000G)
G==0341 (1314/3854,ALSPAC)
G==0329 (1221/3708,TWINSUK)
chr15:97902567 (GRCh38.p7) (15q26.2)
AD
GWASdb2
1   publication(s)
See rs on genome
35 Enhancers around
2 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 15NC_000015.10:g.97902567G>A
GRCh37.p13 chr 15NC_000015.9:g.98445797G>A

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.264A=0.736
1000GenomesAmericanSub694G=0.480A=0.520
1000GenomesEast AsianSub1008G=0.569A=0.431
1000GenomesEuropeSub1006G=0.356A=0.644
1000GenomesGlobalStudy-wide5008G=0.409A=0.591
1000GenomesSouth AsianSub978G=0.440A=0.560
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.341A=0.659
The Genome Aggregation DatabaseAfricanSub8702G=0.287A=0.713
The Genome Aggregation DatabaseAmericanSub836G=0.420A=0.580
The Genome Aggregation DatabaseEast AsianSub1618G=0.574A=0.426
The Genome Aggregation DatabaseEuropeSub18460G=0.358A=0.642
The Genome Aggregation DatabaseGlobalStudy-wide29918G=0.351A=0.649
The Genome Aggregation DatabaseOtherSub302G=0.390A=0.610
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.341A=0.658
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.329A=0.671
PMID Title Author Journal
24277619ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.Quillen EEAm J Med Genet B Neuropsychiatr Genet

P-Value

SNP ID p-value Traits Study
rs64962670.000289alcohol consumption (maxi-drinks)24277619

eQTL of rs6496267 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs6496267 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr159844220098442895E068-2902
chr159844293798443128E068-2669
chr159844713698447822E0681339
chr159840999398410590E070-35207
chr159844220098442895E070-2902
chr159844293798443128E070-2669
chr159844316398443497E070-2300
chr159844713698447822E0701339
chr159845710798457158E07011310
chr159845765698457706E07011859
chr159845782498457874E07012027
chr159845800498458208E07012207
chr159845862298458692E07012825
chr159845887998459095E07013082
chr159845913298459339E07013335
chr159844643298446493E071635
chr159844220098442895E072-2902
chr159844220098442895E073-2902
chr159844293798443128E073-2669
chr159844316398443497E073-2300
chr159844713698447822E0731339
chr159840999398410590E081-35207
chr159841105798411552E081-34245
chr159844127698441506E081-4291
chr159844178598441864E081-3933
chr159844220098442895E081-2902
chr159844293798443128E081-2669
chr159844713698447822E0811339
chr159840999398410590E082-35207
chr159841105798411552E082-34245
chr159843385298434002E082-11795
chr159844220098442895E082-2902
chr159844293798443128E082-2669
chr159844316398443497E082-2300
chr159844713698447822E0821339







Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr159841861098418939E073-26858
chr159841910498419204E073-26593