rs6506389

Homo sapiens
C>T
None
Check p-value
SNV (Single Nucleotide Variation)
C==0124 (3737/29956,GnomAD)
C==0091 (2657/29118,TOPMED)
C==0066 (330/5008,1000G)
C==0143 (551/3854,ALSPAC)
C==0152 (565/3708,TWINSUK)
chr18:6467157 (GRCh38.p7) (18p11.31)
AD
GWASdb2
1   publication(s)
See rs on genome
30 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 18NC_000018.10:g.6467157C>T
GRCh37.p13 chr 18NC_000018.9:g.6467156C>T

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.014T=0.986
1000GenomesAmericanSub694C=0.080T=0.920
1000GenomesEast AsianSub1008C=0.059T=0.941
1000GenomesEuropeSub1006C=0.163T=0.837
1000GenomesGlobalStudy-wide5008C=0.066T=0.934
1000GenomesSouth AsianSub978C=0.030T=0.970
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.143T=0.857
The Genome Aggregation DatabaseAfricanSub8732C=0.041T=0.959
The Genome Aggregation DatabaseAmericanSub836C=0.080T=0.920
The Genome Aggregation DatabaseEast AsianSub1618C=0.065T=0.935
The Genome Aggregation DatabaseEuropeSub18468C=0.171T=0.828
The Genome Aggregation DatabaseGlobalStudy-wide29956C=0.124T=0.875
The Genome Aggregation DatabaseOtherSub302C=0.100T=0.900
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.091T=0.908
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.152T=0.848
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs65063890.000056alcohol dependence20201924
rs65063890.0000562alcoholismpha002892

eQTL of rs6506389 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs6506389 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr1864760056476055E0678849
chr1864763496476424E0679193
chr1864847436484973E06717587
chr1864850356485330E06717879
chr1864235956423717E068-43439
chr1864847436484973E06817587
chr1864850356485330E06817879
chr1864847436484973E06917587
chr1864850356485330E06917879
chr1864760056476055E0708849
chr1864763496476424E0709193
chr1864770426477135E0709886
chr1864774536477526E07010297
chr1864777296477886E07010573
chr1864780126478505E07010856
chr1864785436478670E07011387
chr1864787106478970E07011554
chr1864850356485330E07017879
chr1864763496476424E0719193
chr1864847436484973E07117587
chr1864760056476055E0728849
chr1864763496476424E0729193
chr1864760056476055E0748849
chr1864763496476424E0749193
chr1864850356485330E07417879
chr1864948846494959E08127728
chr1864951426496084E08127986
chr1864961276496181E08128971
chr1864962276496311E08129071
chr1864964676496580E08129311