rs6507820

Homo sapiens
C>A / C>T
ZBTB7C : Intron Variant
LOC105372104 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
T=0150 (4522/29968,GnomAD)
T=0164 (823/5008,1000G)
T=0076 (292/3854,ALSPAC)
T=0072 (266/3708,TWINSUK)
chr18:48167910 (GRCh38.p7) (18q21.1)
AD
GWASdb2
1   publication(s)
See rs on genome
173 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 18NC_000018.10:g.48167910C>A
GRCh38.p7 chr 18NC_000018.10:g.48167910C>T
GRCh37.p13 chr 18NC_000018.9:g.45694281C>A
GRCh37.p13 chr 18NC_000018.9:g.45694281C>T

Gene: ZBTB7C, zinc finger and BTB domain containing 7C(minus strand)

Molecule type Change Amino acid[Codon] SO Term
ZBTB7C transcript variant 1NM_001318841.1:c.N/AIntron Variant
ZBTB7C transcript variant 2NM_001039360.2:c.N/AGenic Upstream Transcript Variant
ZBTB7C transcript variant X13XM_005258229.4:c.N/AIntron Variant
ZBTB7C transcript variant X1XM_011525861.2:c.N/AIntron Variant
ZBTB7C transcript variant X5XM_011525863.2:c.N/AIntron Variant
ZBTB7C transcript variant X6XM_011525864.2:c.N/AIntron Variant
ZBTB7C transcript variant X7XM_011525865.2:c.N/AIntron Variant
ZBTB7C transcript variant X8XM_011525866.2:c.N/AIntron Variant
ZBTB7C transcript variant X9XM_011525867.2:c.N/AIntron Variant
ZBTB7C transcript variant X10XM_011525869.2:c.N/AIntron Variant
ZBTB7C transcript variant X12XM_011525870.2:c.N/AIntron Variant
ZBTB7C transcript variant X2XM_017025605.1:c.N/AIntron Variant
ZBTB7C transcript variant X3XM_017025606.1:c.N/AIntron Variant
ZBTB7C transcript variant X4XM_017025607.1:c.N/AIntron Variant
ZBTB7C transcript variant X10XM_017025608.1:c.N/AIntron Variant
ZBTB7C transcript variant X12XM_017025609.1:c.N/AIntron Variant
ZBTB7C transcript variant X14XM_011525871.2:c.N/AGenic Upstream Transcript Variant

Gene: LOC105372104, uncharacterized LOC105372104(plus strand)

Molecule type Change Amino acid[Codon] SO Term
LOC105372104 transcript variant X3XR_001753438.1:n.N/AIntron Variant
LOC105372104 transcript variant X3XR_001753439.1:n.N/AIntron Variant
LOC105372104 transcript variant X2XR_001753437.1:n.N/AGenic Upstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.625T=0.375
1000GenomesAmericanSub694C=0.780T=0.220
1000GenomesEast AsianSub1008C=0.913T=0.087
1000GenomesEuropeSub1006C=0.935T=0.065
1000GenomesGlobalStudy-wide5008C=0.836T=0.164
1000GenomesSouth AsianSub978C=0.980T=0.020
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.924T=0.076
The Genome Aggregation DatabaseAfricanSub8716C=0.675T=0.325
The Genome Aggregation DatabaseAmericanSub836C=0.750T=0.250
The Genome Aggregation DatabaseEast AsianSub1620C=0.922T=0.078
The Genome Aggregation DatabaseEuropeSub18494C=0.929T=0.070
The Genome Aggregation DatabaseGlobalStudy-wide29968C=0.849T=0.150
The Genome Aggregation DatabaseOtherSub302C=0.840T=0.160
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.928T=0.072
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs65078200.000541alcohol dependence20201924

eQTL of rs6507820 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs6507820 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr184662308246623191E067-46745
chr184662320446623291E067-46645
chr184662334846623408E067-46528
chr184662477246624842E067-45094
chr184662484946625091E067-44845
chr184666743046667789E067-2147
chr184666782346667892E067-2044
chr184669472146695197E06724785
chr184669521146695953E06725275
chr184670857746708696E06738641
chr184670912746709177E06739191
chr184670923346709283E06739297
chr184671026746710563E06740331
chr184671059646710846E06740660
chr184671098146711062E06741045
chr184671588546715925E06745949
chr184671599046716125E06746054
chr184671708546717140E06747149
chr184671720046717254E06747264
chr184671981446719895E06749878
chr184662477246624842E068-45094
chr184662484946625091E068-44845
chr184662559046625748E068-44188
chr184662579746625847E068-44089
chr184666183046661905E068-8031
chr184666219946662278E068-7658
chr184666234546662512E068-7424
chr184666337246663441E068-6495
chr184666609346666370E068-3566
chr184670487946704986E06834943
chr184670512646705541E06835190
chr184670555346705603E06835617
chr184670566246705722E06835726
chr184670605246706125E06836116
chr184671208546712321E06842149
chr184671269946713007E06842763
chr184671588546715925E06845949
chr184671599046716125E06846054
chr184671616446716374E06846228
chr184671649246716886E06846556
chr184671708546717140E06847149
chr184671720046717254E06847264
chr184671772946717811E06847793
chr184671981446719895E06849878
chr184662255046622654E069-47282
chr184662308246623191E069-46745
chr184662320446623291E069-46645
chr184662334846623408E069-46528
chr184662362846623860E069-46076
chr184662415846624232E069-45704
chr184662477246624842E069-45094
chr184662484946625091E069-44845
chr184662559046625748E069-44188
chr184662579746625847E069-44089
chr184666219946662278E069-7658
chr184666234546662512E069-7424
chr184666653546666700E069-3236
chr184666718246667285E069-2651
chr184666743046667789E069-2147
chr184666782346667892E069-2044
chr184669472146695197E06924785
chr184669521146695953E06925275
chr184670405746704823E06934121
chr184670487946704986E06934943
chr184670512646705541E06935190
chr184671026746710563E06940331
chr184671059646710846E06940660
chr184671098146711062E06941045
chr184671208546712321E06942149
chr184671269946713007E06942763
chr184671588546715925E06945949
chr184671599046716125E06946054
chr184671616446716374E06946228
chr184671649246716886E06946556
chr184671708546717140E06947149
chr184664987846650053E070-19883
chr184665006046650137E070-19799
chr184665020546650291E070-19645
chr184666609346666370E070-3566
chr184666653546666700E070-3236
chr184666782346667892E070-2044
chr184670152146701998E07031585
chr184670205046702146E07032114
chr184670218746702305E07032251
chr184662255046622654E071-47282
chr184662308246623191E071-46745
chr184662320446623291E071-46645
chr184662334846623408E071-46528
chr184662415846624232E071-45704
chr184662477246624842E071-45094
chr184662484946625091E071-44845
chr184662559046625748E071-44188
chr184666219946662278E071-7658
chr184666234546662512E071-7424
chr184666609346666370E071-3566
chr184666653546666700E071-3236
chr184666743046667789E071-2147
chr184666782346667892E071-2044
chr184669472146695197E07124785
chr184669521146695953E07125275
chr184670152146701998E07131585
chr184670205046702146E07132114
chr184670218746702305E07132251
chr184670512646705541E07135190
chr184670555346705603E07135617
chr184670566246705722E07135726
chr184670912746709177E07139191
chr184670923346709283E07139297
chr184671269946713007E07142763
chr184671588546715925E07145949
chr184671599046716125E07146054
chr184671616446716374E07146228
chr184671649246716886E07146556
chr184671708546717140E07147149
chr184671720046717254E07147264
chr184671772946717811E07147793
chr184662308246623191E072-46745
chr184662320446623291E072-46645
chr184662334846623408E072-46528
chr184662477246624842E072-45094
chr184662484946625091E072-44845
chr184666743046667789E072-2147
chr184666782346667892E072-2044
chr184670705946707103E07237123
chr184671269946713007E07242763
chr184671588546715925E07245949
chr184671599046716125E07246054
chr184671616446716374E07246228
chr184671649246716886E07246556
chr184671708546717140E07247149
chr184666782346667892E073-2044
chr184670512646705541E07335190
chr184670555346705603E07335617
chr184670566246705722E07335726
chr184671649246716886E07346556
chr184671708546717140E07347149
chr184671720046717254E07347264
chr184671772946717811E07347793
chr184662055146621042E074-48894
chr184662477246624842E074-45094
chr184662484946625091E074-44845
chr184662559046625748E074-44188
chr184662579746625847E074-44089
chr184662610046626200E074-43736
chr184662626846626357E074-43579
chr184662646646626516E074-43420
chr184666183046661905E074-8031
chr184666219946662278E074-7658
chr184666234546662512E074-7424
chr184666609346666370E074-3566
chr184666653546666700E074-3236
chr184666718246667285E074-2651
chr184666743046667789E074-2147
chr184666782346667892E074-2044
chr184669472146695197E07424785
chr184669521146695953E07425275
chr184670857746708696E07438641
chr184670912746709177E07439191
chr184670923346709283E07439297
chr184671026746710563E07440331
chr184671059646710846E07440660
chr184671208546712321E07442149
chr184671269946713007E07442763
chr184671588546715925E07445949
chr184671599046716125E07446054
chr184671616446716374E07446228
chr184671649246716886E07446556
chr184671708546717140E07447149
chr184671720046717254E07447264
chr184671772946717811E07447793
chr184670152146701998E08231585
chr184670205046702146E08232114
chr184670218746702305E08232251