rs6530877

Homo sapiens
C>A / C>G / C>T
None
Check p-value
SNV (Single Nucleotide Variation)
T=0272 (8162/29922,GnomAD)
T=0230 (6715/29118,TOPMED)
T=0176 (883/5008,1000G)
T=0309 (1189/3854,ALSPAC)
T=0319 (1184/3708,TWINSUK)
chr8:15498525 (GRCh38.p7) (8p22)
AD
GWASdb2
1   publication(s)
See rs on genome
14 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 8NC_000008.11:g.15498525C>A
GRCh38.p7 chr 8NC_000008.11:g.15498525C>G
GRCh38.p7 chr 8NC_000008.11:g.15498525C>T
GRCh37.p13 chr 8NC_000008.10:g.15356034C>A
GRCh37.p13 chr 8NC_000008.10:g.15356034C>G
GRCh37.p13 chr 8NC_000008.10:g.15356034C>T

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.871T=0.129
1000GenomesAmericanSub694C=0.760T=0.240
1000GenomesEast AsianSub1008C=0.904T=0.096
1000GenomesEuropeSub1006C=0.697T=0.303
1000GenomesGlobalStudy-wide5008C=0.824T=0.176
1000GenomesSouth AsianSub978C=0.850T=0.150
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.691T=0.309
The Genome Aggregation DatabaseAfricanSub8710C=0.832T=0.168
The Genome Aggregation DatabaseAmericanSub838C=0.780T=0.22,
The Genome Aggregation DatabaseEast AsianSub1614C=0.924T=0.076
The Genome Aggregation DatabaseEuropeSub18460C=0.656T=0.342
The Genome Aggregation DatabaseGlobalStudy-wide29922C=0.727T=0.272
The Genome Aggregation DatabaseOtherSub300C=0.800T=0.20,
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.769T=0.230
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.681T=0.319
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs65308770.00011alcohol dependence(early age of onset)20201924
rs65308770.00073alcohol dependence20201924

eQTL of rs6530877 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs6530877 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr8116089393116089467E067-49652
chr8116123763116123846E070-15273
chr8116123931116124026E070-15093
chr8116124137116124187E070-14932
chr8116124269116124427E070-14692
chr8116124646116124708E070-14411
chr8116127359116127437E071-11682
chr8116127639116127789E071-11330
chr8116115272116115334E081-23785
chr8116115343116115482E081-23637
chr8116115493116115543E081-23576
chr8116115598116115717E081-23402
chr8116115868116116063E081-23056
chr8116155053116155767E08215934