rs6531365

Homo sapiens
A>C
None
Check p-value
SNV (Single Nucleotide Variation)
C=0486 (14506/29798,GnomAD)
A==0494 (14394/29118,TOPMED)
C=0479 (2398/5008,1000G)
C=0491 (1892/3854,ALSPAC)
A==0498 (1848/3708,TWINSUK)
chr4:35513859 (GRCh38.p7) (4p15.1)
ND
GWASdb2
1   publication(s)
See rs on genome
3 Enhancers around
18 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 4NC_000004.12:g.35513859A>C
GRCh37.p13 chr 4NC_000004.11:g.35515481A>C

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.489C=0.511
1000GenomesAmericanSub694A=0.460C=0.540
1000GenomesEast AsianSub1008A=0.707C=0.293
1000GenomesEuropeSub1006A=0.535C=0.465
1000GenomesGlobalStudy-wide5008A=0.521C=0.479
1000GenomesSouth AsianSub978A=0.400C=0.600
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.509C=0.491
The Genome Aggregation DatabaseAfricanSub8694A=0.491C=0.509
The Genome Aggregation DatabaseAmericanSub834A=0.430C=0.570
The Genome Aggregation DatabaseEast AsianSub1588A=0.736C=0.264
The Genome Aggregation DatabaseEuropeSub18380A=0.507C=0.492
The Genome Aggregation DatabaseGlobalStudy-wide29798A=0.513C=0.486
The Genome Aggregation DatabaseOtherSub302A=0.580C=0.420
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.494C=0.505
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.498C=0.502
PMID Title Author Journal
17158188Novel genes identified in a high-density genome wide association study for nicotine dependence.Bierut LJHum Mol Genet

P-Value

SNP ID p-value Traits Study
rs65313650.000343nicotine dependence17158188

eQTL of rs6531365 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs6531365 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr43552673735526787E07411256
chr43553670135536912E08221220
chr43553699835537160E08221517


Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr43546683035466880E067-48601
chr43552687235526986E06811391
chr43552703435527236E06811553
chr43552753335527608E06812052
chr43546683035466880E069-48601
chr43552687235526986E06911391
chr43552703435527236E06911553
chr43546683035466880E071-48601
chr43552687235526986E07111391
chr43552703435527236E07111553
chr43552753335527608E07112052
chr43546683035466880E072-48601
chr43552687235526986E07211391
chr43552703435527236E07211553
chr43552687235526986E07311391
chr43552703435527236E07311553
chr43552687235526986E07411391
chr43552703435527236E07411553