SNP Detail Info-rs6531367

Organism: Homo sapiens

Alleles: A>G

Gene : Feature

None

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

G=0485 (14506/29878,GnomAD)
A==0494 (14394/29118,TOPMED)
G=0478 (2394/5008,1000G)
G=0490 (1889/3854,ALSPAC)
A==0500 (1854/3708,TWINSUK)
G=0500 (1854/3708,TWINSUK)

Position: chr4:35514005 (GRCh38.p7) (4p15.1)

Phenotype: ND

Dataset:

GWASdb2

Publications: 1 publication(s)

Genomic View: See rs on genome

Enhancer: 3 Enhancers around

Promoter: 18 Promoters around

Variant Details Frequency Publications p-values eSNP meSNP

Genomic Coordinates

Sequence Name	Change(s)
GRCh38.p7 chr 4	NC_000004.12:g.35514005A>G
GRCh37.p13 chr 4	NC_000004.11:g.35515627A>G

Population Frequency

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	A=0.489	G=0.511
1000Genomes	American	Sub	694	A=0.460	G=0.540
1000Genomes	East Asian	Sub	1008	A=0.707	G=0.293
1000Genomes	Europe	Sub	1006	A=0.535	G=0.465
1000Genomes	Global	Study-wide	5008	A=0.522	G=0.478
1000Genomes	South Asian	Sub	978	A=0.400	G=0.600
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	A=0.510	G=0.490
The Genome Aggregation Database	African	Sub	8704	A=0.492	G=0.508
The Genome Aggregation Database	American	Sub	834	A=0.430	G=0.570
The Genome Aggregation Database	East Asian	Sub	1602	A=0.740	G=0.260
The Genome Aggregation Database	Europe	Sub	18436	A=0.508	G=0.491
The Genome Aggregation Database	Global	Study-wide	29878	A=0.514	G=0.485
The Genome Aggregation Database	Other	Sub	302	A=0.580	G=0.420
Trans-Omics for Precision Medicine	Global	Study-wide	29118	A=0.494	G=0.505
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	A=0.500	G=0.500

PMID	Title	Author	Journal
17158188	Novel genes identified in a high-density genome wide association study for nicotine dependence.	Bierut LJ	Hum Mol Genet

P-Value

SNP ID	p-value	Traits	Study
rs6531367	0.000276	nicotine dependence	17158188

eQTL of rs6531367 in Brain tissues (GTEx Analysis Release V7)

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

meQTL of rs6531367 in Fetal Brain

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

Chromosome	Start	End	Region	Distance ( -/+ : Up/Downstream )
chr4	35526737	35526787	E074	11110
chr4	35536701	35536912	E082	21074
chr4	35536998	35537160	E082	21371

Promoter Annotation (GRCh37.p13)

Chromosome	Start	End	Region	Distance(-/+:Up/Downstream)
chr4	35466830	35466880	E067	-48747
chr4	35526872	35526986	E068	11245
chr4	35527034	35527236	E068	11407
chr4	35527533	35527608	E068	11906
chr4	35466830	35466880	E069	-48747
chr4	35526872	35526986	E069	11245
chr4	35527034	35527236	E069	11407
chr4	35466830	35466880	E071	-48747
chr4	35526872	35526986	E071	11245
chr4	35527034	35527236	E071	11407
chr4	35527533	35527608	E071	11906
chr4	35466830	35466880	E072	-48747
chr4	35526872	35526986	E072	11245
chr4	35527034	35527236	E072	11407
chr4	35526872	35526986	E073	11245
chr4	35527034	35527236	E073	11407
chr4	35526872	35526986	E074	11245
chr4	35527034	35527236	E074	11407

rs6531367

Genomic Coordinates

Population Frequency

P-Value

eQTL of rs6531367 in Brain tissues (GTEx Analysis Release V7)

meQTL of rs6531367 in Fetal Brain

Genomic View

Chromatin Interaction

Enhancer Annotation (GRCh37.p13)

Promoter Annotation (GRCh37.p13)