rs6531380

Homo sapiens
C>T
None
Check p-value
SNV (Single Nucleotide Variation)
T=0473 (14109/29830,GnomAD)
T=0481 (14016/29118,TOPMED)
T=0466 (2335/5008,1000G)
T=0497 (1917/3854,ALSPAC)
C==0494 (1831/3708,TWINSUK)
chr4:35529029 (GRCh38.p7) (4p15.1)
ND
GWASdb2
1   publication(s)
See rs on genome
3 Enhancers around
14 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 4NC_000004.12:g.35529029C>T
GRCh37.p13 chr 4NC_000004.11:g.35530651C>T

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.554T=0.446
1000GenomesAmericanSub694C=0.470T=0.530
1000GenomesEast AsianSub1008C=0.705T=0.295
1000GenomesEuropeSub1006C=0.527T=0.473
1000GenomesGlobalStudy-wide5008C=0.534T=0.466
1000GenomesSouth AsianSub978C=0.380T=0.620
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.503T=0.497
The Genome Aggregation DatabaseAfricanSub8708C=0.548T=0.452
The Genome Aggregation DatabaseAmericanSub834C=0.430T=0.570
The Genome Aggregation DatabaseEast AsianSub1618C=0.743T=0.257
The Genome Aggregation DatabaseEuropeSub18368C=0.501T=0.498
The Genome Aggregation DatabaseGlobalStudy-wide29830C=0.527T=0.473
The Genome Aggregation DatabaseOtherSub302C=0.570T=0.430
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.518T=0.481
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.494T=0.506
PMID Title Author Journal
17158188Novel genes identified in a high-density genome wide association study for nicotine dependence.Bierut LJHum Mol Genet

P-Value

SNP ID p-value Traits Study
rs65313800.00018nicotine dependence17158188

eQTL of rs6531380 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs6531380 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr43552673735526787E074-3864
chr43553670135536912E0826050
chr43553699835537160E0826347


Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr43552687235526986E068-3665
chr43552703435527236E068-3415
chr43552753335527608E068-3043
chr43552687235526986E069-3665
chr43552703435527236E069-3415
chr43552687235526986E071-3665
chr43552703435527236E071-3415
chr43552753335527608E071-3043
chr43552687235526986E072-3665
chr43552703435527236E072-3415
chr43552687235526986E073-3665
chr43552703435527236E073-3415
chr43552687235526986E074-3665
chr43552703435527236E074-3415