rs6532194

Homo sapiens
C>G / C>T
None
Check p-value
SNV (Single Nucleotide Variation)
T=0276 (8048/29118,TOPMED)
T=0230 (6447/27994,GnomAD)
T=0369 (1850/5008,1000G)
T=0086 (332/3854,ALSPAC)
T=0083 (309/3708,TWINSUK)
chr4:89859751 (GRCh38.p7) (4q22.1)
AD
GWASdb2
5   publication(s)
See rs on genome
0 Enhancer around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 4NC_000004.12:g.89859751C>G
GRCh38.p7 chr 4NC_000004.12:g.89859751C>T
GRCh37.p13 chr 4NC_000004.11:g.90780902C>G
GRCh37.p13 chr 4NC_000004.11:g.90780902C>T

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.492T=0.508
1000GenomesAmericanSub694C=0.680T=0.320
1000GenomesEast AsianSub1008C=0.453T=0.547
1000GenomesEuropeSub1006C=0.907T=0.093
1000GenomesGlobalStudy-wide5008C=0.631T=0.369
1000GenomesSouth AsianSub978C=0.680T=0.320
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.914T=0.086
The Genome Aggregation DatabaseAfricanSub8368C=0.547T=0.453
The Genome Aggregation DatabaseAmericanSub544C=0.720T=0.280
The Genome Aggregation DatabaseEast AsianSub1596C=0.459T=0.541
The Genome Aggregation DatabaseEuropeSub17186C=0.907T=0.092
The Genome Aggregation DatabaseGlobalStudy-wide27994C=0.769T=0.230
The Genome Aggregation DatabaseOtherSub300C=0.840T=0.160
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.723T=0.276
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.917T=0.083
PMID Title Author Journal
21703634A meta-analysis of two genome-wide association studies identifies 3 new loci for alcohol dependence.Wang KSJ Psychiatr Res
21268244Association of GWAS loci with PD in China.Chang XLAm J Med Genet B Neuropsychiatr Genet
22892372Using genome-wide complex trait analysis to quantify 'missing heritability' in Parkinson's disease.Keller MFHum Mol Genet
22086882No association between Parkinson disease alleles and the risk of melanoma.Meng SCancer Epidemiol Biomarkers Prev
22438815Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database.Lill CMPLoS Genet

P-Value

SNP ID p-value Traits Study
rs65321949.69E-05alcohol dependence21703634

eQTL of rs6532194 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs6532194 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.