rs6532798

Homo sapiens
C>T
ADH4 : Intron Variant
LOC100507053 : Non Coding Transcript Variant
Check p-value
SNV (Single Nucleotide Variation)
C==0255 (7657/29920,GnomAD)
C==0243 (7091/29118,TOPMED)
C==0153 (766/5008,1000G)
C==0308 (1187/3854,ALSPAC)
C==0316 (1170/3708,TWINSUK)
chr4:99133676 (GRCh38.p7) (4q23)
AD
GWASCatalog
1   publication(s)
See rs on genome
7 Enhancers around
37 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 4NC_000004.12:g.99133676C>T
GRCh37.p13 chr 4NC_000004.11:g.100054827C>T

Gene: ADH4, alcohol dehydrogenase 4 (class II), pi polypeptide(minus strand)

Molecule type Change Amino acid[Codon] SO Term
ADH4 transcript variant 3NM_000670.4:c.N/AIntron Variant
ADH4 transcript variant 1NM_001306171.1:c.N/AIntron Variant
ADH4 transcript variant 2NM_001306172.1:c.N/AIntron Variant
ADH4 transcript variant X1XM_017007713.1:c.N/AIntron Variant
ADH4 transcript variant X2XM_017007714.1:c.N/AIntron Variant
ADH4 transcript variant X3XM_017007715.1:c.N/AIntron Variant

Gene: LOC100507053, uncharacterized LOC100507053(plus strand)

Molecule type Change Amino acid[Codon] SO Term
LOC100507053 transcriptNR_037884.1:n.550C>TC>TNon Coding Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.139T=0.861
1000GenomesAmericanSub694C=0.230T=0.770
1000GenomesEast AsianSub1008C=0.001T=0.999
1000GenomesEuropeSub1006C=0.303T=0.697
1000GenomesGlobalStudy-wide5008C=0.153T=0.847
1000GenomesSouth AsianSub978C=0.120T=0.880
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.308T=0.692
The Genome Aggregation DatabaseAfricanSub8718C=0.175T=0.825
The Genome Aggregation DatabaseAmericanSub838C=0.250T=0.750
The Genome Aggregation DatabaseEast AsianSub1620C=0.002T=0.998
The Genome Aggregation DatabaseEuropeSub18444C=0.315T=0.684
The Genome Aggregation DatabaseGlobalStudy-wide29920C=0.255T=0.744
The Genome Aggregation DatabaseOtherSub300C=0.310T=0.690
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.243T=0.756
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.316T=0.684
PMID Title Author Journal
24166409Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci.Gelernter JMol Psychiatry

P-Value

SNP ID p-value Traits Study
rs65327987E-06alcohol dependence24166409

eQTL of rs6532798 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs6532798 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr4100006643100006704E070-48123
chr4100006873100006947E070-47880
chr4100012091100012363E071-42464
chr4100006873100006947E081-47880
chr4100007948100008019E081-46808
chr4100006643100006704E082-48123
chr4100006873100006947E082-47880




Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr4100008829100008950E067-45877
chr4100009042100010625E067-44202
chr4100010636100011572E067-43255
chr4100008829100008950E068-45877
chr4100009042100010625E068-44202
chr4100010636100011572E068-43255
chr4100008645100008721E069-46106
chr4100008829100008950E069-45877
chr4100009042100010625E069-44202
chr4100010636100011572E069-43255
chr4100008158100008256E070-46571
chr4100008370100008613E070-46214
chr4100008645100008721E070-46106
chr4100008829100008950E070-45877
chr4100009042100010625E070-44202
chr4100010636100011572E070-43255
chr4100009042100010625E071-44202
chr4100010636100011572E071-43255
chr4100008829100008950E072-45877
chr4100009042100010625E072-44202
chr4100010636100011572E072-43255
chr4100008829100008950E073-45877
chr4100009042100010625E073-44202
chr4100010636100011572E073-43255
chr4100009042100010625E074-44202
chr4100010636100011572E074-43255
chr4100008645100008721E081-46106
chr4100008829100008950E081-45877
chr4100009042100010625E081-44202
chr4100010636100011572E081-43255
chr4100007472100007769E082-47058
chr4100008158100008256E082-46571
chr4100008370100008613E082-46214
chr4100008645100008721E082-46106
chr4100008829100008950E082-45877
chr4100009042100010625E082-44202
chr4100010636100011572E082-43255