rs6536915

Homo sapiens
C>T
CPE : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
C==0292 (8738/29918,GnomAD)
C==0305 (8903/29118,TOPMED)
C==0287 (1436/5008,1000G)
C==0338 (1301/3854,ALSPAC)
C==0333 (1236/3708,TWINSUK)
chr4:165463215 (GRCh38.p7) (4q32.3)
AD
GWASdb2
1   publication(s)
See rs on genome
95 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 4NC_000004.12:g.165463215C>T
GRCh37.p13 chr 4NC_000004.11:g.166384367C>T

Gene: CPE, carboxypeptidase E(plus strand)

Molecule type Change Amino acid[Codon] SO Term
CPE transcriptNM_001873.3:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.190T=0.810
1000GenomesAmericanSub694C=0.370T=0.630
1000GenomesEast AsianSub1008C=0.195T=0.805
1000GenomesEuropeSub1006C=0.333T=0.667
1000GenomesGlobalStudy-wide5008C=0.287T=0.713
1000GenomesSouth AsianSub978C=0.410T=0.590
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.338T=0.662
The Genome Aggregation DatabaseAfricanSub8704C=0.232T=0.768
The Genome Aggregation DatabaseAmericanSub834C=0.410T=0.590
The Genome Aggregation DatabaseEast AsianSub1618C=0.227T=0.773
The Genome Aggregation DatabaseEuropeSub18460C=0.317T=0.682
The Genome Aggregation DatabaseGlobalStudy-wide29918C=0.292T=0.707
The Genome Aggregation DatabaseOtherSub302C=0.470T=0.530
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.305T=0.694
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.333T=0.667
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs65369150.00046alcohol dependence20201924

eQTL of rs6536915 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs6536915 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr4166361272166361388E067-22979
chr4166361537166362053E067-22314
chr4166362349166362444E067-21923
chr4166384764166384821E067397
chr4166385572166385757E0671205
chr4166335973166336035E068-48332
chr4166336107166336178E068-48189
chr4166340406166340481E068-43886
chr4166360488166360542E068-23825
chr4166360599166360821E068-23546
chr4166361272166361388E068-22979
chr4166361537166362053E068-22314
chr4166379268166379334E068-5033
chr4166379773166380065E068-4302
chr4166380380166380567E068-3800
chr4166382401166383095E068-1272
chr4166384764166384821E068397
chr4166385572166385757E0681205
chr4166385882166386278E0681515
chr4166360488166360542E069-23825
chr4166360599166360821E069-23546
chr4166361272166361388E069-22979
chr4166361537166362053E069-22314
chr4166384764166384821E069397
chr4166385572166385757E0691205
chr4166433545166433595E07049178
chr4166433702166433900E07049335
chr4166360488166360542E071-23825
chr4166360599166360821E071-23546
chr4166361272166361388E071-22979
chr4166361537166362053E071-22314
chr4166362349166362444E071-21923
chr4166379268166379334E071-5033
chr4166385572166385757E0711205
chr4166414372166414469E07130005
chr4166414516166414868E07130149
chr4166361537166362053E072-22314
chr4166362349166362444E072-21923
chr4166379268166379334E072-5033
chr4166379773166380065E072-4302
chr4166361537166362053E073-22314
chr4166362349166362444E073-21923
chr4166385572166385757E0731205
chr4166428099166428207E07343732
chr4166360488166360542E074-23825
chr4166360599166360821E074-23546
chr4166361272166361388E074-22979
chr4166361537166362053E074-22314
chr4166362349166362444E074-21923
chr4166379268166379334E074-5033
chr4166382401166383095E074-1272
chr4166385572166385757E0741205
chr4166385882166386278E0741515
chr4166411040166411313E07426673
chr4166428099166428207E07443732
chr4166335627166335693E081-48674
chr4166335973166336035E081-48332
chr4166336107166336178E081-48189
chr4166337205166337320E081-47047
chr4166338457166338570E081-45797
chr4166360488166360542E081-23825
chr4166360599166360821E081-23546
chr4166361272166361388E081-22979
chr4166361537166362053E081-22314
chr4166362349166362444E081-21923
chr4166362946166363021E081-21346
chr4166379131166379187E081-5180
chr4166379268166379334E081-5033
chr4166379773166380065E081-4302
chr4166381409166381508E081-2859
chr4166381671166381746E081-2621
chr4166381780166381831E081-2536
chr4166384764166384821E081397
chr4166385572166385757E0811205
chr4166385882166386278E0811515
chr4166414372166414469E08130005
chr4166414516166414868E08130149
chr4166433545166433595E08149178
chr4166433702166433900E08149335
chr4166335627166335693E082-48674
chr4166335973166336035E082-48332
chr4166336107166336178E082-48189
chr4166360488166360542E082-23825
chr4166360599166360821E082-23546
chr4166361272166361388E082-22979
chr4166361537166362053E082-22314
chr4166362349166362444E082-21923
chr4166379131166379187E082-5180
chr4166379268166379334E082-5033
chr4166381409166381508E082-2859
chr4166381671166381746E082-2621
chr4166384764166384821E082397
chr4166385572166385757E0821205
chr4166433545166433595E08249178
chr4166433702166433900E08249335