SNP Detail Info-rs6536987

Organism: Homo sapiens

Alleles: A>G

Gene : Feature

None

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

A==0449 (13351/29696,GnomAD)
A==0438 (12757/29116,TOPMED)
A==0381 (1906/5008,1000G)
G=0475 (1830/3854,ALSPAC)
G=0477 (1767/3708,TWINSUK)

Position: chr4:166607472 (GRCh38.p7) (4q32.3)

Phenotype: AD

Dataset:

GWASdb2

Publications: 1 publication(s)

Genomic View: See rs on genome

Enhancer: 0 Enhancer around

Promoter: 0 Promoter around

Sequence Name	Change(s)
GRCh38.p7 chr 4	NC_000004.12:g.166607472A>G
GRCh37.p13 chr 4	NC_000004.11:g.167528623A>G

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	A=0.388	G=0.612
1000Genomes	American	Sub	694	A=0.290	G=0.710
1000Genomes	East Asian	Sub	1008	A=0.222	G=0.778
1000Genomes	Europe	Sub	1006	A=0.540	G=0.460
1000Genomes	Global	Study-wide	5008	A=0.381	G=0.619
1000Genomes	South Asian	Sub	978	A=0.430	G=0.570
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	A=0.525	G=0.475
The Genome Aggregation Database	African	Sub	8680	A=0.384	G=0.616
The Genome Aggregation Database	American	Sub	832	A=0.270	G=0.730
The Genome Aggregation Database	East Asian	Sub	1582	A=0.197	G=0.803
The Genome Aggregation Database	Europe	Sub	18300	A=0.510	G=0.489
The Genome Aggregation Database	Global	Study-wide	29696	A=0.449	G=0.550
The Genome Aggregation Database	Other	Sub	302	A=0.450	G=0.550
Trans-Omics for Precision Medicine	Global	Study-wide	29116	A=0.438	G=0.561
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	A=0.523	G=0.477

PMID	Title	Author	Journal
24277619	ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.	Quillen EE	Am J Med Genet B Neuropsychiatr Genet

SNP ID	p-value	Traits	Study
rs6536987	0.000125	alcohol dependence	24277619

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

rs6536987