rs6552767

Homo sapiens
G>A
ENPP6 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
A=0328 (9836/29904,GnomAD)
A=0340 (9906/29118,TOPMED)
A=0259 (1298/5008,1000G)
A=0335 (1293/3854,ALSPAC)
A=0336 (1246/3708,TWINSUK)
chr4:184188841 (GRCh38.p7) (4q35.1)
AD
GWASdb2
1   publication(s)
See rs on genome
73 Enhancers around
34 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 4NC_000004.12:g.184188841G>A
GRCh37.p13 chr 4NC_000004.11:g.185109994G>A

Gene: ENPP6, ectonucleotide pyrophosphatase/phosphodiesterase 6(minus strand)

Molecule type Change Amino acid[Codon] SO Term
ENPP6 transcriptNM_153343.3:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.648A=0.352
1000GenomesAmericanSub694G=0.760A=0.240
1000GenomesEast AsianSub1008G=0.975A=0.025
1000GenomesEuropeSub1006G=0.650A=0.350
1000GenomesGlobalStudy-wide5008G=0.741A=0.259
1000GenomesSouth AsianSub978G=0.700A=0.300
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.665A=0.335
The Genome Aggregation DatabaseAfricanSub8702G=0.622A=0.378
The Genome Aggregation DatabaseAmericanSub838G=0.790A=0.210
The Genome Aggregation DatabaseEast AsianSub1620G=0.969A=0.031
The Genome Aggregation DatabaseEuropeSub18442G=0.664A=0.335
The Genome Aggregation DatabaseGlobalStudy-wide29904G=0.671A=0.328
The Genome Aggregation DatabaseOtherSub302G=0.550A=0.450
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.659A=0.340
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.664A=0.336
PMID Title Author Journal
21314694Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample.Kendler KSAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs65527670.000952alcohol dependence21314694

eQTL of rs6552767 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs6552767 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr4185075087185075154E067-34840
chr4185076687185076735E067-33259
chr4185076799185076897E067-33097
chr4185077325185077721E067-32273
chr4185118948185119204E0678954
chr4185119218185119332E0679224
chr4185119364185119431E0679370
chr4185136918185137151E06726924
chr4185110538185110876E068544
chr4185110895185110955E068901
chr4185111819185112101E0681825
chr4185158717185158856E06848723
chr4185158912185159029E06848918
chr4185076687185076735E069-33259
chr4185076799185076897E069-33097
chr4185077325185077721E069-32273
chr4185111819185112101E0691825
chr4185118948185119204E0698954
chr4185119218185119332E0699224
chr4185119364185119431E0699370
chr4185136620185136745E06926626
chr4185158717185158856E06948723
chr4185158912185159029E06948918
chr4185136139185136551E07026145
chr4185136620185136745E07026626
chr4185136918185137151E07026924
chr4185076687185076735E071-33259
chr4185076799185076897E071-33097
chr4185088708185089365E071-20629
chr4185110538185110876E071544
chr4185110895185110955E071901
chr4185111138185111481E0711144
chr4185111819185112101E0711825
chr4185118948185119204E0718954
chr4185119218185119332E0719224
chr4185119364185119431E0719370
chr4185136620185136745E07126626
chr4185158717185158856E07148723
chr4185158912185159029E07148918
chr4185076687185076735E072-33259
chr4185076799185076897E072-33097
chr4185077325185077721E072-32273
chr4185111819185112101E0721825
chr4185119218185119332E0729224
chr4185119364185119431E0729370
chr4185136620185136745E07226626
chr4185076687185076735E073-33259
chr4185076799185076897E073-33097
chr4185077325185077721E073-32273
chr4185110895185110955E073901
chr4185111138185111481E0731144
chr4185111819185112101E0731825
chr4185077325185077721E074-32273
chr4185090232185090448E074-19546
chr4185110053185110113E07459
chr4185110538185110876E074544
chr4185110895185110955E074901
chr4185111138185111481E0741144
chr4185111819185112101E0741825
chr4185118734185118824E0748740
chr4185118948185119204E0748954
chr4185119218185119332E0749224
chr4185119364185119431E0749370
chr4185136139185136551E07426145
chr4185136620185136745E07426626
chr4185139463185139533E07429469
chr4185158717185158856E07448723
chr4185158912185159029E07448918
chr4185074720185074812E081-35182
chr4185075087185075154E081-34840
chr4185075197185075327E081-34667
chr4185075087185075154E082-34840
chr4185075197185075327E082-34667










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr4185137165185137496E06727171
chr4185137729185138007E06727735
chr4185138351185138495E06728357
chr4185138797185138935E06728803
chr4185139007185139161E06729013
chr4185114636185114712E0684642
chr4185137165185137496E06827171
chr4185137729185138007E06827735
chr4185138351185138495E06828357
chr4185138797185138935E06828803
chr4185139007185139161E06829013
chr4185137165185137496E06927171
chr4185137729185138007E06927735
chr4185138351185138495E06928357
chr4185138797185138935E06928803
chr4185139007185139161E06929013
chr4185137165185137496E07127171
chr4185137729185138007E07127735
chr4185138351185138495E07128357
chr4185138797185138935E07128803
chr4185139007185139161E07129013
chr4185137165185137496E07227171
chr4185137729185138007E07227735
chr4185138351185138495E07228357
chr4185138797185138935E07228803
chr4185137165185137496E07327171
chr4185137729185138007E07327735
chr4185138351185138495E07328357
chr4185138797185138935E07328803
chr4185137165185137496E07427171
chr4185137729185138007E07427735
chr4185138351185138495E07428357
chr4185138797185138935E07428803
chr4185139007185139161E07429013