rs6558545

Homo sapiens
G>A
None
Check p-value
SNV (Single Nucleotide Variation)
G==0391 (11695/29872,GnomAD)
G==0411 (11982/29116,TOPMED)
G==0396 (1984/5008,1000G)
G==0400 (1542/3854,ALSPAC)
G==0412 (1529/3708,TWINSUK)
chr8:1808419 (GRCh38.p7) (8p23.3)
AD
GWASdb2
2   publication(s)
See rs on genome
474 Enhancers around
29 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 8NC_000008.11:g.1808419G>A
GRCh37.p13 chr 8NC_000008.10:g.1756585G>A
GRCh38.p7 chr 8 alt locus HSCHR8_7_CTG1NT_187680.1:g.221077G>A

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.394A=0.606
1000GenomesAmericanSub694G=0.460A=0.540
1000GenomesEast AsianSub1008G=0.291A=0.709
1000GenomesEuropeSub1006G=0.414A=0.586
1000GenomesGlobalStudy-wide5008G=0.396A=0.604
1000GenomesSouth AsianSub978G=0.450A=0.550
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.400A=0.600
The Genome Aggregation DatabaseAfricanSub8684G=0.427A=0.573
The Genome Aggregation DatabaseAmericanSub836G=0.450A=0.550
The Genome Aggregation DatabaseEast AsianSub1614G=0.283A=0.717
The Genome Aggregation DatabaseEuropeSub18436G=0.381A=0.618
The Genome Aggregation DatabaseGlobalStudy-wide29872G=0.391A=0.608
The Genome Aggregation DatabaseOtherSub302G=0.380A=0.620
Trans-Omics for Precision MedicineGlobalStudy-wide29116G=0.411A=0.588
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.412A=0.588
PMID Title Author Journal
24351102Gene variations of ROCKs and risk of ischaemic stroke: the Women's Genome Health Study.Zee RYLClin Sci (Lond)
24277619ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.Quillen EEAm J Med Genet B Neuropsychiatr Genet

P-Value

SNP ID p-value Traits Study
rs65585450.000626alcohol consumption (maxi-drinks)24277619

eQTL of rs6558545 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs6558545 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr817135921714729E067-41856
chr817165351716624E067-39961
chr817166791717154E067-39431
chr817171611717579E067-39006
chr817175831717632E067-38953
chr817176551718072E067-38513
chr817355461736646E067-19939
chr817611531761322E0674568
chr817619791763086E0675394
chr817631661763489E0676581
chr817637771763876E0677192
chr817641901764317E0677605
chr817798741780434E06723289
chr817811601781214E06724575
chr817816521781702E06725067
chr817818931782027E06725308
chr817820601782110E06725475
chr817821131782223E06725528
chr817835831783760E06726998
chr817838281783948E06727243
chr817839631784003E06727378
chr817844961784790E06727911
chr817853981785473E06728813
chr817857151786039E06729130
chr817862031786291E06729618
chr817863471786922E06729762
chr817888721789343E06732287
chr817894701789555E06732885
chr817895631789640E06732978
chr817896421789738E06733057
chr817904001791448E06733815
chr817914581791543E06734873
chr817917241791784E06735139
chr817918441791979E06735259
chr817946151794665E06738030
chr817951221795182E06738537
chr817952411795626E06738656
chr817956901795937E06739105
chr818014921801638E06744907
chr818017561801796E06745171
chr818019411802100E06745356
chr817165351716624E068-39961
chr817166791717154E068-39431
chr817171611717579E068-39006
chr817175831717632E068-38953
chr817266961726915E068-29670
chr817269191726995E068-29590
chr817276641728118E068-28467
chr817281691728832E068-27753
chr817289321728987E068-27598
chr817290081729174E068-27411
chr817291911729231E068-27354
chr817293571729426E068-27159
chr817295151729947E068-26638
chr817299611730011E068-26574
chr817300411730081E068-26504
chr817300911730156E068-26429
chr817342431735103E068-21482
chr817351171735442E068-21143
chr817355461736646E068-19939
chr817611531761322E0684568
chr817614241761556E0684839
chr817615601761654E0684975
chr817617961761849E0685211
chr817619791763086E0685394
chr817631661763489E0686581
chr817637771763876E0687192
chr817641901764317E0687605
chr817703521770691E06813767
chr817707251770837E06814140
chr817708901770957E06814305
chr817710151771059E06814430
chr817811601781214E06824575
chr817835831783760E06826998
chr817853981785473E06828813
chr817857151786039E06829130
chr817862031786291E06829618
chr817863471786922E06829762
chr817875051787559E06830920
chr817888721789343E06832287
chr817894701789555E06832885
chr817895631789640E06832978
chr817896421789738E06833057
chr817897621789894E06833177
chr817898991789986E06833314
chr817904001791448E06833815
chr817914581791543E06834873
chr817917241791784E06835139
chr817918441791979E06835259
chr817940081794413E06837423
chr817946151794665E06838030
chr817951221795182E06838537
chr817952411795626E06838656
chr818019411802100E06845356
chr818050631805113E06848478
chr818051161805217E06848531
chr817135921714729E069-41856
chr817148661715721E069-40864
chr817165351716624E069-39961
chr817166791717154E069-39431
chr817171611717579E069-39006
chr817175831717632E069-38953
chr817176551718072E069-38513
chr817184281718478E069-38107
chr817185591718613E069-37972
chr817238581723936E069-32649
chr817243961724625E069-31960
chr817246321724682E069-31903
chr817246881724764E069-31821
chr817249631725363E069-31222
chr817261361726425E069-30160
chr817266961726915E069-29670
chr817269191726995E069-29590
chr817271861727357E069-29228
chr817274541727571E069-29014
chr817276641728118E069-28467
chr817281691728832E069-27753
chr817289321728987E069-27598
chr817290081729174E069-27411
chr817291911729231E069-27354
chr817293571729426E069-27159
chr817295151729947E069-26638
chr817341581734215E069-22370
chr817342431735103E069-21482
chr817351171735442E069-21143
chr817355461736646E069-19939
chr817369951737735E069-18850
chr817377451737828E069-18757
chr817574241757749E069839
chr817611531761322E0694568
chr817614241761556E0694839
chr817615601761654E0694975
chr817631661763489E0696581
chr817637771763876E0697192
chr817641901764317E0697605
chr817707251770837E06914140
chr817708901770957E06914305
chr817710151771059E06914430
chr817736841775235E06917099
chr817753091775359E06918724
chr817757961775882E06919211
chr817811601781214E06924575
chr817816521781702E06925067
chr817818931782027E06925308
chr817820601782110E06925475
chr817821131782223E06925528
chr817826101782660E06926025
chr817827841782885E06926199
chr817831261783250E06926541
chr817833801783436E06926795
chr817835831783760E06926998
chr817838281783948E06927243
chr817839631784003E06927378
chr817844961784790E06927911
chr817853981785473E06928813
chr817857151786039E06929130
chr817862031786291E06929618
chr817863471786922E06929762
chr817875051787559E06930920
chr817888721789343E06932287
chr817894701789555E06932885
chr817895631789640E06932978
chr817896421789738E06933057
chr817904001791448E06933815
chr817914581791543E06934873
chr817917241791784E06935139
chr817918441791979E06935259
chr817940081794413E06937423
chr817951221795182E06938537
chr817952411795626E06938656
chr817956901795937E06939105
chr817959411796061E06939356
chr817960891796201E06939504
chr817962461796324E06939661
chr817963781796564E06939793
chr817965871796641E06940002
chr818014921801638E06944907
chr818017561801796E06945171
chr818019411802100E06945356
chr818063121806426E06949727
chr817736841775235E07017099
chr817904001791448E07033815
chr817952411795626E07038656
chr817956901795937E07039105
chr817959411796061E07039356
chr817960891796201E07039504
chr817962461796324E07039661
chr817963781796564E07039793
chr817965871796641E07040002
chr817135921714729E071-41856
chr817148661715721E071-40864
chr817165351716624E071-39961
chr817166791717154E071-39431
chr817171611717579E071-39006
chr817175831717632E071-38953
chr817176551718072E071-38513
chr817184281718478E071-38107
chr817185591718613E071-37972
chr817243961724625E071-31960
chr817261361726425E071-30160
chr817266961726915E071-29670
chr817269191726995E071-29590
chr817271861727357E071-29228
chr817274541727571E071-29014
chr817276641728118E071-28467
chr817281691728832E071-27753
chr817289321728987E071-27598
chr817290081729174E071-27411
chr817291911729231E071-27354
chr817340051734138E071-22447
chr817341581734215E071-22370
chr817342431735103E071-21482
chr817351171735442E071-21143
chr817355461736646E071-19939
chr817369951737735E071-18850
chr817574241757749E071839
chr817631661763489E0716581
chr817637771763876E0717192
chr817710151771059E07114430
chr817753091775359E07118724
chr817757961775882E07119211
chr817759931776442E07119408
chr817816521781702E07125067
chr817818931782027E07125308
chr817820601782110E07125475
chr817821131782223E07125528
chr817826101782660E07126025
chr817827841782885E07126199
chr817831261783250E07126541
chr817833801783436E07126795
chr817838281783948E07127243
chr817839631784003E07127378
chr817844961784790E07127911
chr817853981785473E07128813
chr817857151786039E07129130
chr817862031786291E07129618
chr817863471786922E07129762
chr817875051787559E07130920
chr817888721789343E07132287
chr817894701789555E07132885
chr817895631789640E07132978
chr817896421789738E07133057
chr817897621789894E07133177
chr817898991789986E07133314
chr817904001791448E07133815
chr817918441791979E07135259
chr817935911793677E07137006
chr817940081794413E07137423
chr817946151794665E07138030
chr817951221795182E07138537
chr817952411795626E07138656
chr817956901795937E07139105
chr817959411796061E07139356
chr818014921801638E07144907
chr818017561801796E07145171
chr818019411802100E07145356
chr818038511803901E07147266
chr817135921714729E072-41856
chr817165351716624E072-39961
chr817166791717154E072-39431
chr817171611717579E072-39006
chr817175831717632E072-38953
chr817176551718072E072-38513
chr817184281718478E072-38107
chr817185591718613E072-37972
chr817189091718959E072-37626
chr817191131719167E072-37418
chr817192981719358E072-37227
chr817194161719466E072-37119
chr817238581723936E072-32649
chr817243961724625E072-31960
chr817246321724682E072-31903
chr817246881724764E072-31821
chr817266961726915E072-29670
chr817269191726995E072-29590
chr817271861727357E072-29228
chr817274541727571E072-29014
chr817276641728118E072-28467
chr817281691728832E072-27753
chr817289321728987E072-27598
chr817290081729174E072-27411
chr817291911729231E072-27354
chr817351171735442E072-21143
chr817369951737735E072-18850
chr817377451737828E072-18757
chr817574241757749E072839
chr817611531761322E0724568
chr817637771763876E0727192
chr817641901764317E0727605
chr817710151771059E07214430
chr817736841775235E07217099
chr817753091775359E07218724
chr817771271778712E07220542
chr817790021779064E07222417
chr817791921779252E07222607
chr817793751779507E07222790
chr817798741780434E07223289
chr817804371780537E07223852
chr817816521781702E07225067
chr817818931782027E07225308
chr817820601782110E07225475
chr817821131782223E07225528
chr817835831783760E07226998
chr817838281783948E07227243
chr817839631784003E07227378
chr817853981785473E07228813
chr817857151786039E07229130
chr817862031786291E07229618
chr817863471786922E07229762
chr817875051787559E07230920
chr817888721789343E07232287
chr817894701789555E07232885
chr817895631789640E07232978
chr817896421789738E07233057
chr817897621789894E07233177
chr817898991789986E07233314
chr817904001791448E07233815
chr817914581791543E07234873
chr817917241791784E07235139
chr817918441791979E07235259
chr817935911793677E07237006
chr817940081794413E07237423
chr817946151794665E07238030
chr817951221795182E07238537
chr817952411795626E07238656
chr817956901795937E07239105
chr817959411796061E07239356
chr817963781796564E07239793
chr817965871796641E07240002
chr818010081801061E07244423
chr818014921801638E07244907
chr818017561801796E07245171
chr818019411802100E07245356
chr818063121806426E07249727
chr817135921714729E073-41856
chr817148661715721E073-40864
chr817165351716624E073-39961
chr817166791717154E073-39431
chr817171611717579E073-39006
chr817175831717632E073-38953
chr817209871721428E073-35157
chr817216511721733E073-34852
chr817266961726915E073-29670
chr817269191726995E073-29590
chr817271861727357E073-29228
chr817276641728118E073-28467
chr817281691728832E073-27753
chr817341581734215E073-22370
chr817342431735103E073-21482
chr817351171735442E073-21143
chr817355461736646E073-19939
chr817611531761322E0734568
chr817614241761556E0734839
chr817615601761654E0734975
chr817616591761749E0735074
chr817617961761849E0735211
chr817619791763086E0735394
chr817631661763489E0736581
chr817771271778712E07320542
chr817816521781702E07325067
chr817818931782027E07325308
chr817820601782110E07325475
chr817821131782223E07325528
chr817835831783760E07326998
chr817838281783948E07327243
chr817862031786291E07329618
chr817863471786922E07329762
chr817896421789738E07333057
chr817897621789894E07333177
chr817904001791448E07333815
chr817914581791543E07334873
chr817917241791784E07335139
chr817918441791979E07335259
chr817951221795182E07338537
chr817952411795626E07338656
chr817956901795937E07339105
chr817959411796061E07339356
chr817960891796201E07339504
chr817962461796324E07339661
chr817963781796564E07339793
chr817965871796641E07340002
chr817976731797733E07341088
chr818014921801638E07344907
chr818017561801796E07345171
chr818019411802100E07345356
chr817135921714729E074-41856
chr817165351716624E074-39961
chr817166791717154E074-39431
chr817171611717579E074-39006
chr817175831717632E074-38953
chr817176551718072E074-38513
chr817184281718478E074-38107
chr817243961724625E074-31960
chr817246321724682E074-31903
chr817246881724764E074-31821
chr817249631725363E074-31222
chr817266961726915E074-29670
chr817269191726995E074-29590
chr817271861727357E074-29228
chr817274541727571E074-29014
chr817276641728118E074-28467
chr817281691728832E074-27753
chr817289321728987E074-27598
chr817290081729174E074-27411
chr817291911729231E074-27354
chr817340051734138E074-22447
chr817341581734215E074-22370
chr817342431735103E074-21482
chr817351171735442E074-21143
chr817355461736646E074-19939
chr817369951737735E074-18850
chr817574241757749E074839
chr817637771763876E0747192
chr817710151771059E07414430
chr817753091775359E07418724
chr817787691778843E07422184
chr817790021779064E07422417
chr817791921779252E07422607
chr817793751779507E07422790
chr817798741780434E07423289
chr817804371780537E07423852
chr817816521781702E07425067
chr817818931782027E07425308
chr817820601782110E07425475
chr817821131782223E07425528
chr817835831783760E07426998
chr817838281783948E07427243
chr817839631784003E07427378
chr817844961784790E07427911
chr817853981785473E07428813
chr817857151786039E07429130
chr817862031786291E07429618
chr817863471786922E07429762
chr817875051787559E07430920
chr817888721789343E07432287
chr817894701789555E07432885
chr817895631789640E07432978
chr817896421789738E07433057
chr817897621789894E07433177
chr817898991789986E07433314
chr817904001791448E07433815
chr817917241791784E07435139
chr817918441791979E07435259
chr817923461792423E07435761
chr817935911793677E07437006
chr817940081794413E07437423
chr817946151794665E07438030
chr817951221795182E07438537
chr817952411795626E07438656
chr817956901795937E07439105
chr817959411796061E07439356
chr817960891796201E07439504
chr817963781796564E07439793
chr817965871796641E07440002
chr818014921801638E07444907
chr818017561801796E07445171
chr818019411802100E07445356
chr817355461736646E081-19939
chr817736841775235E08117099
chr817753091775359E08118724
chr817952411795626E08138656
chr817956901795937E08139105
chr817959411796061E08139356
chr817960891796201E08139504
chr817962461796324E08139661
chr817963781796564E08139793
chr817965871796641E08140002
chr818063121806426E08149727
chr817952411795626E08238656
chr817956901795937E08239105
chr817959411796061E08239356
chr817960891796201E08239504
chr817962461796324E08239661
chr817963781796564E08239793










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr817105071711590E067-44995
chr817117561713532E067-43053
chr817710931772751E06714508
chr817105071711590E068-44995
chr817117561713532E068-43053
chr817710931772751E06814508
chr817105071711590E069-44995
chr817117561713532E069-43053
chr817710931772751E06914508
chr817105071711590E070-44995
chr817117561713532E070-43053
chr817710931772751E07014508
chr817729461773229E07016361
chr817105071711590E071-44995
chr817117561713532E071-43053
chr817710931772751E07114508
chr817105071711590E072-44995
chr817117561713532E072-43053
chr817710931772751E07214508
chr817105071711590E073-44995
chr817117561713532E073-43053
chr817710931772751E07314508
chr817105071711590E074-44995
chr817117561713532E074-43053
chr817710931772751E07414508
chr817105071711590E081-44995
chr817105071711590E082-44995
chr817117561713532E082-43053
chr817710931772751E08214508