rs6583607

Homo sapiens
T>C
TSNARE1 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
T==0483 (14351/29678,GnomAD)
T==0430 (12537/29118,TOPMED)
T==0410 (2053/5008,1000G)
C=0441 (1700/3854,ALSPAC)
C=0431 (1599/3708,TWINSUK)
chr8:142243038 (GRCh38.p7) (8q24.3)
AD
GWASdb2
1   publication(s)
See rs on genome
129 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 8NC_000008.11:g.142243038T>C
GRCh37.p13 chr 8NC_000008.10:g.143324399T>C

Gene: TSNARE1, t-SNARE domain containing 1(minus strand)

Molecule type Change Amino acid[Codon] SO Term
TSNARE1 transcript variant 1NM_145003.4:c.N/AIntron Variant
TSNARE1 transcript variant 2NM_001291931.1:c.N/AGenic Downstream Transcript Variant
TSNARE1 transcript variant X11XM_017013176.1:c.N/AIntron Variant
TSNARE1 transcript variant X15XM_017013177.1:c.N/AIntron Variant
TSNARE1 transcript variant X16XM_017013178.1:c.N/AIntron Variant
TSNARE1 transcript variant X1XM_011516912.1:c.N/AGenic Downstream Transcript Variant
TSNARE1 transcript variant X6XM_011516913.2:c.N/AGenic Downstream Transcript Variant
TSNARE1 transcript variant X1XM_011516914.1:c.N/AGenic Downstream Transcript Variant
TSNARE1 transcript variant X2XM_011516915.2:c.N/AGenic Downstream Transcript Variant
TSNARE1 transcript variant X3XM_011516916.1:c.N/AGenic Downstream Transcript Variant
TSNARE1 transcript variant X4XM_011516917.2:c.N/AGenic Downstream Transcript Variant
TSNARE1 transcript variant X7XM_011516918.1:c.N/AGenic Downstream Transcript Variant
TSNARE1 transcript variant X12XM_011516919.1:c.N/AGenic Downstream Transcript Variant
TSNARE1 transcript variant X13XM_011516920.1:c.N/AGenic Downstream Transcript Variant
TSNARE1 transcript variant X19XM_011516921.1:c.N/AGenic Downstream Transcript Variant
TSNARE1 transcript variant X20XM_011516922.1:c.N/AGenic Downstream Transcript Variant
TSNARE1 transcript variant X21XM_011516923.2:c.N/AGenic Downstream Transcript Variant
TSNARE1 transcript variant X23XM_011516924.1:c.N/AGenic Downstream Transcript Variant
TSNARE1 transcript variant X8XM_017013175.1:c.N/AGenic Downstream Transcript Variant
TSNARE1 transcript variant X17XM_017013179.1:c.N/AGenic Downstream Transcript Variant
TSNARE1 transcript variant X18XM_017013180.1:c.N/AGenic Downstream Transcript Variant
TSNARE1 transcript variant X22XM_017013181.1:c.N/AGenic Downstream Transcript Variant
TSNARE1 transcript variant X9XR_928307.2:n.N/AGenic Downstream Transcript Variant
TSNARE1 transcript variant X10XR_928308.1:n.N/AGenic Downstream Transcript Variant
TSNARE1 transcript variant X14XR_928309.1:n.N/AGenic Downstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.261C=0.739
1000GenomesAmericanSub694T=0.370C=0.630
1000GenomesEast AsianSub1008T=0.494C=0.506
1000GenomesEuropeSub1006T=0.569C=0.431
1000GenomesGlobalStudy-wide5008T=0.410C=0.590
1000GenomesSouth AsianSub978T=0.390C=0.610
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.559C=0.441
The Genome Aggregation DatabaseAfricanSub8634T=0.323C=0.677
The Genome Aggregation DatabaseAmericanSub832T=0.380C=0.620
The Genome Aggregation DatabaseEast AsianSub1608T=0.483C=0.517
The Genome Aggregation DatabaseEuropeSub18304T=0.562C=0.437
The Genome Aggregation DatabaseGlobalStudy-wide29678T=0.483C=0.516
The Genome Aggregation DatabaseOtherSub300T=0.570C=0.430
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.430C=0.569
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.569C=0.431
PMID Title Author Journal
21314694Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample.Kendler KSAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs65836070.000891alcohol dependence21314694

eQTL of rs6583607 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs6583607 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr8143370417143370507E06746018
chr8143370541143370675E06746142
chr8143370747143370873E06746348
chr8143274593143274785E068-49614
chr8143274905143275130E068-49269
chr8143284525143284871E068-39528
chr8143284937143285549E068-38850
chr8143285791143285841E068-38558
chr8143285984143286036E068-38363
chr8143286206143286246E068-38153
chr8143286296143286346E068-38053
chr8143372956143373046E06848557
chr8143373102143373161E06848703
chr8143370339143370389E06945940
chr8143370417143370507E06946018
chr8143370541143370675E06946142
chr8143370747143370873E06946348
chr8143291713143292311E070-32088
chr8143370339143370389E07045940
chr8143370417143370507E07046018
chr8143370541143370675E07046142
chr8143370747143370873E07046348
chr8143371079143371419E07046680
chr8143371507143371563E07047108
chr8143371618143371708E07047219
chr8143371727143372009E07047328
chr8143372152143372232E07047753
chr8143372348143372419E07047949
chr8143370339143370389E07145940
chr8143370417143370507E07146018
chr8143370541143370675E07146142
chr8143370747143370873E07146348
chr8143371079143371419E07146680
chr8143371507143371563E07147108
chr8143371618143371708E07147219
chr8143371727143372009E07147328
chr8143372152143372232E07147753
chr8143274593143274785E072-49614
chr8143274905143275130E072-49269
chr8143275185143275274E072-49125
chr8143275346143275410E072-48989
chr8143275536143275621E072-48778
chr8143369982143370167E07245583
chr8143370339143370389E07245940
chr8143371727143372009E07247328
chr8143372152143372232E07247753
chr8143372348143372419E07247949
chr8143372667143372789E07248268
chr8143372956143373046E07248557
chr8143373102143373161E07248703
chr8143373518143373582E07249119
chr8143274593143274785E073-49614
chr8143274905143275130E073-49269
chr8143369982143370167E07345583
chr8143370339143370389E07345940
chr8143370417143370507E07346018
chr8143370541143370675E07346142
chr8143370747143370873E07346348
chr8143372152143372232E07347753
chr8143372348143372419E07347949
chr8143372667143372789E07348268
chr8143373518143373582E07349119
chr8143373975143374049E07349576
chr8143374160143374210E07349761
chr8143274905143275130E074-49269
chr8143275185143275274E074-49125
chr8143274593143274785E081-49614
chr8143274905143275130E081-49269
chr8143275185143275274E081-49125
chr8143275346143275410E081-48989
chr8143293917143293967E081-30432
chr8143294048143294106E081-30293
chr8143294219143294807E081-29592
chr8143294863143294913E081-29486
chr8143294983143295033E081-29366
chr8143295053143295228E081-29171
chr8143295488143295564E081-28835
chr8143296980143297240E081-27159
chr8143297334143297405E081-26994
chr8143297563143297753E081-26646
chr8143297807143297887E081-26512
chr8143297951143298024E081-26375
chr8143305927143306470E081-17929
chr8143306572143306622E081-17777
chr8143330596143330664E0816197
chr8143330728143330806E0816329
chr8143330843143331158E0816444
chr8143331199143331371E0816800
chr8143331430143331654E0817031
chr8143331770143332028E0817371
chr8143332071143332121E0817672
chr8143334994143335038E08110595
chr8143335393143335648E08110994
chr8143335693143335978E08111294
chr8143339439143339766E08115040
chr8143355948143355998E08131549
chr8143356138143356348E08131739
chr8143369982143370167E08145583
chr8143370339143370389E08145940
chr8143370417143370507E08146018
chr8143370541143370675E08146142
chr8143370747143370873E08146348
chr8143371079143371419E08146680
chr8143371507143371563E08147108
chr8143371618143371708E08147219
chr8143371727143372009E08147328
chr8143372152143372232E08147753
chr8143372348143372419E08147949
chr8143372667143372789E08148268
chr8143372956143373046E08148557
chr8143373102143373161E08148703
chr8143373518143373582E08149119
chr8143274593143274785E082-49614
chr8143274905143275130E082-49269
chr8143294219143294807E082-29592
chr8143294863143294913E082-29486
chr8143294983143295033E082-29366
chr8143295053143295228E082-29171
chr8143297807143297887E082-26512
chr8143297951143298024E082-26375
chr8143330728143330806E0826329
chr8143330843143331158E0826444
chr8143331199143331371E0826800
chr8143331430143331654E0827031
chr8143331770143332028E0827371
chr8143334994143335038E08210595
chr8143371727143372009E08247328
chr8143372152143372232E08247753
chr8143372348143372419E08247949