rs6585783

Homo sapiens
T>C
None
Check p-value
SNV (Single Nucleotide Variation)
T==0461 (13797/29892,GnomAD)
T==0373 (10860/29118,TOPMED)
T==0391 (1959/5008,1000G)
C=0408 (1571/3854,ALSPAC)
C=0399 (1481/3708,TWINSUK)
chr10:84029554 (GRCh38.p7) (10q23.1)
AD
GWASdb2
2   publication(s)
See rs on genome
3 Enhancers around
2 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 10NC_000010.11:g.84029554T>C
GRCh37.p13 chr 10NC_000010.10:g.85789310T>C

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.051C=0.949
1000GenomesAmericanSub694T=0.480C=0.520
1000GenomesEast AsianSub1008T=0.490C=0.510
1000GenomesEuropeSub1006T=0.604C=0.396
1000GenomesGlobalStudy-wide5008T=0.391C=0.609
1000GenomesSouth AsianSub978T=0.470C=0.530
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.592C=0.408
The Genome Aggregation DatabaseAfricanSub8698T=0.137C=0.863
The Genome Aggregation DatabaseAmericanSub836T=0.510C=0.490
The Genome Aggregation DatabaseEast AsianSub1610T=0.555C=0.445
The Genome Aggregation DatabaseEuropeSub18446T=0.605C=0.394
The Genome Aggregation DatabaseGlobalStudy-wide29892T=0.461C=0.538
The Genome Aggregation DatabaseOtherSub302T=0.390C=0.610
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.373C=0.627
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.601C=0.399
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res
20202923A genome-wide association study of alcohol dependence.Bierut LJProc Natl Acad Sci U S A

P-Value

SNP ID p-value Traits Study
rs65857830.00000802alcohol dependence20202923
rs65857830.00034alcohol dependence(Early onset)20201924
rs65857830.00044alcohol dependence20201924

eQTL of rs6585783 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs6585783 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr108575954585759629E070-29681
chr108575974285759810E070-29500
chr108576019985760257E070-29053

Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr108580917085809315E06819860
chr108580917085809315E07119860