rs6586879

Homo sapiens
C>T
LOC107986921 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
T=0113 (3409/29944,GnomAD)
T=0175 (5098/29118,TOPMED)
T=0130 (653/5008,1000G)
T=0021 (82/3854,ALSPAC)
T=0021 (79/3708,TWINSUK)
chr8:19905221 (GRCh38.p7) (8p21.3)
AD
GWASdb2
1   publication(s)
See rs on genome
27 Enhancers around
11 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 8NC_000008.11:g.19905221C>T
GRCh37.p13 chr 8NC_000008.10:g.19762732C>T

Gene: LOC107986921, uncharacterized LOC107986921(plus strand)

Molecule type Change Amino acid[Codon] SO Term
LOC107986921 transcriptXR_001745822.1:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.557T=0.443
1000GenomesAmericanSub694C=0.970T=0.030
1000GenomesEast AsianSub1008C=0.999T=0.001
1000GenomesEuropeSub1006C=0.989T=0.011
1000GenomesGlobalStudy-wide5008C=0.870T=0.130
1000GenomesSouth AsianSub978C=0.970T=0.030
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.979T=0.021
The Genome Aggregation DatabaseAfricanSub8692C=0.636T=0.364
The Genome Aggregation DatabaseAmericanSub838C=0.980T=0.020
The Genome Aggregation DatabaseEast AsianSub1620C=1.000T=0.000
The Genome Aggregation DatabaseEuropeSub18492C=0.988T=0.011
The Genome Aggregation DatabaseGlobalStudy-wide29944C=0.886T=0.113
The Genome Aggregation DatabaseOtherSub302C=0.950T=0.050
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.824T=0.175
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.979T=0.021
PMID Title Author Journal
21314694Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample.Kendler KSAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs65868790.000245alcohol dependence21314694

eQTL of rs6586879 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs6586879 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr81975899719759301E067-3431
chr81979848319798691E06735751
chr81971275919712897E068-49835
chr81975899719759301E068-3431
chr81971275919712897E069-49835
chr81975899719759301E069-3431
chr81981145619811506E07048724
chr81981156619811760E07048834
chr81971538919715488E071-47244
chr81971552119715587E071-47145
chr81975899719759301E071-3431
chr81975899719759301E072-3431
chr81971275919712897E073-49835
chr81971498519715298E073-47434
chr81971538919715488E073-47244
chr81971552119715587E073-47145
chr81975899719759301E074-3431
chr81979848319798691E07435751
chr81971275919712897E081-49835
chr81971715919717775E081-44957
chr81971780119718152E081-44580
chr81979421119794312E08131479
chr81979438419795353E08131652
chr81979872419799068E08135992
chr81979917519799271E08136443
chr81980200919802214E08139277
chr81979438419795353E08231652










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr81979587019798424E06733138
chr81979587019798424E06833138
chr81979943319799550E06836701
chr81979587019798424E06933138
chr81979587019798424E07133138
chr81979587019798424E07233138
chr81979587019798424E07333138
chr81979587019798424E07433138
chr81979587019798424E08133138
chr81979587019798424E08233138
chr81979943319799550E08236701