rs663749

Homo sapiens
G>C
None
Check p-value
SNV (Single Nucleotide Variation)
C=0310 (9300/29910,GnomAD)
C=0327 (9541/29118,TOPMED)
C=0354 (1771/5008,1000G)
C=0270 (1042/3854,ALSPAC)
C=0265 (981/3708,TWINSUK)
chr18:11957686 (GRCh38.p7) (18p11.21)
AD
GWASdb2
1   publication(s)
See rs on genome
46 Enhancers around
15 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 18NC_000018.10:g.11957686G>C
GRCh37.p13 chr 18NC_000018.9:g.11957685G>C

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.611C=0.389
1000GenomesAmericanSub694G=0.740C=0.260
1000GenomesEast AsianSub1008G=0.572C=0.428
1000GenomesEuropeSub1006G=0.772C=0.228
1000GenomesGlobalStudy-wide5008G=0.646C=0.354
1000GenomesSouth AsianSub978G=0.570C=0.430
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.730C=0.270
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.672C=0.327
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.735C=0.265
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs6637490.00038alcohol dependence20201924

eQTL of rs663749 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs663749 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr181196275411962961E0675069
chr181196306811963176E0675383
chr181199417211996346E06736487
chr181195434411954832E068-2853
chr181195485311955116E068-2569
chr181195517011955236E068-2449
chr181195526511956010E068-1675
chr181199417211996346E06836487
chr181195485311955116E070-2569
chr181195517011955236E070-2449
chr181195526511956010E070-1675
chr181198686311986913E07029178
chr181199700711997225E07039322
chr181199732011997389E07039635
chr181199768111997764E07039996
chr181199781511997880E07040130
chr181199796311998007E07040278
chr181199811311998163E07040428
chr181199824311998534E07040558
chr181199861711998676E07040932
chr181199953911999650E07041854
chr181199978111999835E07042096
chr181195434411954832E071-2853
chr181195485311955116E071-2569
chr181195517011955236E071-2449
chr181195526511956010E071-1675
chr181196275411962961E0715069
chr181196306811963176E0715383
chr181199417211996346E07136487
chr181199635311996452E07138668
chr181199655611996606E07138871
chr181199662611996775E07138941
chr181199686111996981E07139176
chr181199700711997225E07139322
chr181199732011997389E07139635
chr181199768111997764E07139996
chr181199781511997880E07140130
chr181199796311998007E07140278
chr181199811311998163E07140428
chr181199824311998534E07140558
chr181199417211996346E07236487
chr181199417211996346E07336487
chr181195526511956010E074-1675
chr181199905211999127E08241367
chr181199953911999650E08241854
chr181199978111999835E08242096








Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr181194605311948381E067-9304
chr181197988711982541E06722202
chr181194605311948381E068-9304
chr181197988711982541E06822202
chr181194605311948381E069-9304
chr181197988711982541E06922202
chr181197988711982541E07022202
chr181194605311948381E071-9304
chr181197988711982541E07122202
chr181197988711982541E07222202
chr181194605311948381E073-9304
chr181197988711982541E07322202
chr181194605311948381E074-9304
chr181197988711982541E07422202
chr181197988711982541E08222202