rs6657754

Homo sapiens
C>A / C>T
None
Check p-value
SNV (Single Nucleotide Variation)
A=0296 (8874/29942,GnomAD)
A=0358 (10434/29116,TOPMED)
A=0345 (1728/5008,1000G)
A=0162 (625/3854,ALSPAC)
A=0167 (620/3708,TWINSUK)
chr1:242710653 (GRCh38.p7) (1q43)
AD
GWASdb2
1   publication(s)
See rs on genome

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 1NC_000001.11:g.242710653C>A
GRCh38.p7 chr 1NC_000001.11:g.242710653C>T
GRCh37.p13 chr 1NC_000001.10:g.242873955C>A
GRCh37.p13 chr 1NC_000001.10:g.242873955C>T

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.375A=0.625
1000GenomesAmericanSub694C=0.730A=0.270
1000GenomesEast AsianSub1008C=0.676A=0.324
1000GenomesEuropeSub1006C=0.832A=0.168
1000GenomesGlobalStudy-wide5008C=0.655A=0.345
1000GenomesSouth AsianSub978C=0.780A=0.220
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.838A=0.162
The Genome Aggregation DatabaseAfricanSub8708C=0.450A=0.550
The Genome Aggregation DatabaseAmericanSub838C=0.730A=0.27,
The Genome Aggregation DatabaseEast AsianSub1616C=0.678A=0.322
The Genome Aggregation DatabaseEuropeSub18478C=0.823A=0.176
The Genome Aggregation DatabaseGlobalStudy-wide29942C=0.703A=0.296
The Genome Aggregation DatabaseOtherSub302C=0.740A=0.26,
Trans-Omics for Precision MedicineGlobalStudy-wide29116C=0.641A=0.358
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.833A=0.167
PMID Title Author Journal
24277619ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.Quillen EEAm J Med Genet B Neuropsychiatr Genet

P-Value

SNP ID p-value Traits Study
rs66577544.1E-05alcohol consumption (maxi-drinks)24277619

eQTL of rs6657754 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs6657754 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr177293367730002E067-49089
chr177300967730344E067-48747
chr177304187730841E067-48250
chr177309717731039E067-48052
chr177630527763177E067-15914
chr177632197763279E067-15812
chr177808837780972E0671792
chr177812487781310E0672157
chr177866297787057E0677538
chr177886147788674E0679523
chr177889917789110E0679900
chr178123517813427E06733260
chr178204947820618E06741403
chr178212637821404E06742172
chr177517407751922E068-27169
chr177520747752124E068-26967
chr177522007752401E068-26690
chr177544937754606E068-24485
chr177551297755174E068-23917
chr177554977755547E068-23544
chr177556227755785E068-23306
chr177625277762700E068-16391
chr177630527763177E068-15914
chr177825727782631E0683481
chr177866297787057E0687538
chr177889917789110E0689900
chr178123517813427E06833260
chr177304187730841E069-48250
chr177551297755174E069-23917
chr177554977755547E069-23544
chr177625277762700E069-16391
chr177630527763177E069-15914
chr177765567777141E069-1950
chr177889917789110E0699900
chr178123517813427E06933260
chr178204947820618E06941403
chr178212637821404E06942172
chr177300967730344E070-48747
chr177304187730841E070-48250
chr177309717731039E070-48052
chr177327967732905E070-46186
chr177329577733376E070-45715
chr177334827733532E070-45559
chr177387677739067E070-40024
chr177395807739766E070-39325
chr177423077742367E070-36724
chr177444177744480E070-34611
chr177445007744592E070-34499
chr177446767744730E070-34361
chr177479747748064E070-31027
chr177554977755547E070-23544
chr177556227755785E070-23306
chr177578247757878E070-21213
chr177630527763177E070-15914
chr177882667788436E0709175
chr178123517813427E07033260
chr177293367730002E071-49089
chr177300967730344E071-48747
chr177304187730841E071-48250
chr177309717731039E071-48052
chr177414417741495E071-37596
chr177415547741664E071-37427
chr177497007749803E071-29288
chr177630527763177E071-15914
chr177632197763279E071-15812
chr177866297787057E0717538
chr178123517813427E07133260
chr177304187730841E072-48250
chr177309717731039E072-48052
chr177387677739067E072-40024
chr177395807739766E072-39325
chr177414417741495E072-37596
chr177415547741664E072-37427
chr177554977755547E072-23544
chr177556227755785E072-23306
chr177625277762700E072-16391
chr177630527763177E072-15914
chr177632197763279E072-15812
chr177765567777141E072-1950
chr177866297787057E0727538
chr177889917789110E0729900
chr177895687789757E07210477
chr178123517813427E07233260
chr178204947820618E07241403
chr177304187730841E073-48250
chr177309717731039E073-48052
chr177395807739766E073-39325
chr177625277762700E073-16391
chr177630527763177E073-15914
chr177632197763279E073-15812
chr177866297787057E0737538
chr177889917789110E0739900
chr178123517813427E07333260
chr178204947820618E07341403
chr177293367730002E074-49089
chr177300967730344E074-48747
chr177625277762700E074-16391
chr177630527763177E074-15914
chr177632197763279E074-15812
chr177866297787057E0747538
chr177886147788674E0749523
chr177889917789110E0749900
chr178123517813427E07433260
chr178204947820618E07441403
chr177293367730002E081-49089
chr177300967730344E081-48747
chr177304187730841E081-48250
chr177309717731039E081-48052
chr177395807739766E081-39325
chr177414417741495E081-37596
chr177415547741664E081-37427
chr177554977755547E081-23544
chr177556227755785E081-23306
chr177625277762700E081-16391
chr177630527763177E081-15914
chr177632197763279E081-15812
chr177673087767348E081-11743
chr177758677775944E081-3147
chr177765567777141E081-1950
chr177778837778384E081-707
chr177808837780972E0811792
chr177812487781310E0812157
chr177866297787057E0817538
chr177882667788436E0819175
chr177886147788674E0819523
chr177889917789110E0819900
chr178123517813427E08133260
chr177293367730002E082-49089
chr177300967730344E082-48747
chr177304187730841E082-48250
chr177309717731039E082-48052
chr177673087767348E082-11743
chr177674387767497E082-11594
chr177758677775944E082-3147
chr177765567777141E082-1950
chr177808837780972E0821792
chr177812487781310E0822157
chr177825727782631E0823481
chr177826727782738E0823581
chr177827417782945E0823650
chr177886147788674E0829523
chr177889917789110E0829900










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr177400557741372E067-37719
chr177637947763895E067-15196
chr177638997764274E067-14817
chr177642867764361E067-14730
chr177644487765049E067-14042
chr177650967765199E067-13892
chr177652347765343E067-13748
chr177654067766078E067-13013
chr177400557741372E068-37719
chr177637947763895E068-15196
chr177638997764274E068-14817
chr177650967765199E068-13892
chr177652347765343E068-13748
chr177654067766078E068-13013
chr177660797766556E068-12535
chr177400557741372E069-37719
chr177637947763895E069-15196
chr177638997764274E069-14817
chr177642867764361E069-14730
chr177644487765049E069-14042
chr177650967765199E069-13892
chr177652347765343E069-13748
chr177654067766078E069-13013
chr177660797766556E069-12535
chr177400557741372E070-37719
chr177637947763895E070-15196
chr177638997764274E070-14817
chr177642867764361E070-14730
chr177644487765049E070-14042
chr177650967765199E070-13892
chr177654067766078E070-13013
chr177660797766556E070-12535
chr177400557741372E071-37719
chr177637947763895E071-15196
chr177638997764274E071-14817
chr177642867764361E071-14730
chr177644487765049E071-14042
chr177650967765199E071-13892
chr177652347765343E071-13748
chr177654067766078E071-13013
chr177660797766556E071-12535
chr177400557741372E072-37719
chr177637947763895E072-15196
chr177638997764274E072-14817
chr177642867764361E072-14730
chr177644487765049E072-14042
chr177650967765199E072-13892
chr177652347765343E072-13748
chr177654067766078E072-13013
chr177660797766556E072-12535
chr177400557741372E073-37719
chr177650967765199E073-13892
chr177652347765343E073-13748
chr177654067766078E073-13013
chr177660797766556E073-12535
chr177400557741372E074-37719
chr177652347765343E074-13748
chr177654067766078E074-13013
chr177660797766556E074-12535
chr177637947763895E081-15196
chr177654067766078E081-13013
chr177660797766556E081-12535
chr177400557741372E082-37719
chr177637947763895E082-15196
chr177638997764274E082-14817
chr177642867764361E082-14730
chr177644487765049E082-14042
chr177650967765199E082-13892
chr177652347765343E082-13748
chr177654067766078E082-13013
chr177660797766556E082-12535