SNP Detail Info-rs6677435

Organism: Homo sapiens

Alleles: G>A

Gene : Feature

None

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

A=0052 (1579/29950,GnomAD)
A=0042 (1222/29118,TOPMED)
A=0100 (500/5008,1000G)
A=0040 (154/3854,ALSPAC)
A=0046 (169/3708,TWINSUK)

Position: chr1:195821528 (GRCh38.p7) (1q31.3)

Phenotype: CD

Dataset:

GWASdb2 | GWASCatalog

Publications: 1 publication(s)

Genomic View: See rs on genome

Enhancer: 3 Enhancers around

Promoter: 0 Promoter around

Sequence Name	Change(s)
GRCh38.p7 chr 1	NC_000001.11:g.195821528G>A
GRCh37.p13 chr 1	NC_000001.10:g.195790658G>A

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	G=0.994	A=0.006
1000Genomes	American	Sub	694	G=0.870	A=0.130
1000Genomes	East Asian	Sub	1008	G=0.733	A=0.267
1000Genomes	Europe	Sub	1006	G=0.958	A=0.042
1000Genomes	Global	Study-wide	5008	G=0.900	A=0.100
1000Genomes	South Asian	Sub	978	G=0.910	A=0.090
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	G=0.960	A=0.040
The Genome Aggregation Database	African	Sub	8718	G=0.985	A=0.015
The Genome Aggregation Database	American	Sub	836	G=0.860	A=0.140
The Genome Aggregation Database	East Asian	Sub	1614	G=0.708	A=0.292
The Genome Aggregation Database	Europe	Sub	18480	G=0.954	A=0.045
The Genome Aggregation Database	Global	Study-wide	29950	G=0.947	A=0.052
The Genome Aggregation Database	Other	Sub	302	G=0.950	A=0.050
Trans-Omics for Precision Medicine	Global	Study-wide	29118	G=0.958	A=0.042
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	G=0.954	A=0.046

PMID	Title	Author	Journal
23958962	Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene.	Gelernter J	Mol Psychiatry

SNP ID	p-value	Traits	Study
rs6677435	0.000009	cocaine dependence	23958962
rs6677435	9.00E-06	cocaine dependence	23958962

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

Chromosome	Start	End	Region	Distance ( -/+ : Up/Downstream )
chr1	195835188	195835756	E074	44530
chr1	195835188	195835756	E081	44530
chr1	195750810	195750918	E082	-39740

rs6677435