rs6677615

Organism: Homo sapiens

Alleles: G>A

Gene : Feature

None

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

A=0323 (9658/29832,GnomAD)
A=0351 (10221/29118,TOPMED)
A=0362 (1813/5008,1000G)
A=0304 (1173/3854,ALSPAC)
A=0293 (1087/3708,TWINSUK)

Position: chr1:23616312 (GRCh38.p7) (1p36.11)

Phenotype: AD

Dataset:

GWASdb2

Publications: 1 publication(s)

Genomic View: See rs on genome

Enhancer: 85 Enhancers around

Promoter: 17 Promoters around

Variant Details Frequency Publications p-values eSNP meSNP

Genomic Coordinates

Sequence Name	Change(s)
GRCh38.p7 chr 1	NC_000001.11:g.23616312G>A
GRCh37.p13 chr 1	NC_000001.10:g.23942802G>A

Population Frequency

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	G=0.594	A=0.406
1000Genomes	American	Sub	694	G=0.580	A=0.420
1000Genomes	East Asian	Sub	1008	G=0.717	A=0.283
1000Genomes	Europe	Sub	1006	G=0.695	A=0.305
1000Genomes	Global	Study-wide	5008	G=0.638	A=0.362
1000Genomes	South Asian	Sub	978	G=0.600	A=0.400
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	G=0.696	A=0.304
The Genome Aggregation Database	African	Sub	8652	G=0.604	A=0.396
The Genome Aggregation Database	American	Sub	836	G=0.540	A=0.460
The Genome Aggregation Database	East Asian	Sub	1606	G=0.683	A=0.317
The Genome Aggregation Database	Europe	Sub	18436	G=0.716	A=0.283
The Genome Aggregation Database	Global	Study-wide	29832	G=0.676	A=0.323
The Genome Aggregation Database	Other	Sub	302	G=0.640	A=0.360
Trans-Omics for Precision Medicine	Global	Study-wide	29118	G=0.649	A=0.351
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	G=0.707	A=0.293

PMID	Title	Author	Journal
20201924	Genome-wide association study of alcohol dependence implicates a region on chromosome 11.	Edenberg HJ	Alcohol Clin Exp Res

P-Value

SNP ID	p-value	Traits	Study
rs6677615	0.00026	alcohol dependence(early age of onset)	20201924
rs6677615	0.00072	alcohol dependence	20201924

eQTL of rs6677615 in Brain tissues (GTEx Analysis Release V7)

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

meQTL of rs6677615 in Fetal Brain

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome	Start	End	Region	Distance ( -/+ : Up/Downstream )
chr1	23896046	23896214	E067	-46588
chr1	23902865	23903094	E067	-39708
chr1	23903180	23903268	E067	-39534
chr1	23903372	23903440	E067	-39362
chr1	23903576	23904312	E067	-38490
chr1	23904341	23904416	E067	-38386
chr1	23907482	23907532	E067	-35270
chr1	23907613	23908132	E067	-34670
chr1	23924067	23925551	E067	-17251
chr1	23960933	23961029	E067	18131
chr1	23961056	23961157	E067	18254
chr1	23961185	23961230	E067	18383
chr1	23896046	23896214	E068	-46588
chr1	23896291	23896349	E068	-46453
chr1	23903180	23903268	E068	-39534
chr1	23903372	23903440	E068	-39362
chr1	23903576	23904312	E068	-38490
chr1	23904341	23904416	E068	-38386
chr1	23904526	23904685	E068	-38117
chr1	23904897	23905091	E068	-37711
chr1	23907482	23907532	E068	-35270
chr1	23907613	23908132	E068	-34670
chr1	23924067	23925551	E068	-17251
chr1	23960933	23961029	E068	18131
chr1	23961056	23961157	E068	18254
chr1	23961185	23961230	E068	18383
chr1	23896046	23896214	E069	-46588
chr1	23896291	23896349	E069	-46453
chr1	23903576	23904312	E069	-38490
chr1	23907482	23907532	E069	-35270
chr1	23907613	23908132	E069	-34670
chr1	23924067	23925551	E069	-17251
chr1	23960933	23961029	E069	18131
chr1	23961056	23961157	E069	18254
chr1	23961185	23961230	E069	18383
chr1	23896046	23896214	E070	-46588
chr1	23896291	23896349	E070	-46453
chr1	23892802	23893155	E071	-49647
chr1	23893321	23893372	E071	-49430
chr1	23893569	23894028	E071	-48774
chr1	23896291	23896349	E071	-46453
chr1	23903576	23904312	E071	-38490
chr1	23904341	23904416	E071	-38386
chr1	23904526	23904685	E071	-38117
chr1	23904897	23905091	E071	-37711
chr1	23907482	23907532	E071	-35270
chr1	23924067	23925551	E071	-17251
chr1	23950883	23950978	E071	8081
chr1	23960933	23961029	E071	18131
chr1	23961056	23961157	E071	18254
chr1	23961185	23961230	E071	18383
chr1	23896046	23896214	E072	-46588
chr1	23896291	23896349	E072	-46453
chr1	23902865	23903094	E072	-39708
chr1	23903180	23903268	E072	-39534
chr1	23903372	23903440	E072	-39362
chr1	23903576	23904312	E072	-38490
chr1	23904341	23904416	E072	-38386
chr1	23907482	23907532	E072	-35270
chr1	23907613	23908132	E072	-34670
chr1	23924067	23925551	E072	-17251
chr1	23960933	23961029	E072	18131
chr1	23961056	23961157	E072	18254
chr1	23896046	23896214	E073	-46588
chr1	23896291	23896349	E073	-46453
chr1	23902865	23903094	E073	-39708
chr1	23903180	23903268	E073	-39534
chr1	23903372	23903440	E073	-39362
chr1	23903576	23904312	E073	-38490
chr1	23904341	23904416	E073	-38386
chr1	23904526	23904685	E073	-38117
chr1	23904897	23905091	E073	-37711
chr1	23924067	23925551	E073	-17251
chr1	23960933	23961029	E073	18131
chr1	23961056	23961157	E073	18254
chr1	23896046	23896214	E074	-46588
chr1	23896291	23896349	E074	-46453
chr1	23904897	23905091	E074	-37711
chr1	23907482	23907532	E074	-35270
chr1	23907613	23908132	E074	-34670
chr1	23924067	23925551	E074	-17251
chr1	23960933	23961029	E074	18131
chr1	23961056	23961157	E074	18254
chr1	23961185	23961230	E074	18383
chr1	23962197	23962321	E074	19395

Promoter Annotation (GRCh37.p13)

Chromosome	Start	End	Region	Distance(-/+:Up/Downstream)
chr1	23894288	23894552	E067	-48250
chr1	23894599	23895909	E067	-46893
chr1	23894288	23894552	E068	-48250
chr1	23894599	23895909	E068	-46893
chr1	23894288	23894552	E069	-48250
chr1	23894599	23895909	E069	-46893
chr1	23894288	23894552	E070	-48250
chr1	23894599	23895909	E070	-46893
chr1	23894288	23894552	E071	-48250
chr1	23894599	23895909	E071	-46893
chr1	23894288	23894552	E072	-48250
chr1	23894599	23895909	E072	-46893
chr1	23894288	23894552	E073	-48250
chr1	23894599	23895909	E073	-46893
chr1	23894599	23895909	E074	-46893
chr1	23894288	23894552	E082	-48250
chr1	23894599	23895909	E082	-46893