rs6681981

Homo sapiens
A>G
NOS1AP : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
G=0317 (9492/29886,GnomAD)
G=0261 (7615/29118,TOPMED)
G=0311 (1558/5008,1000G)
G=0378 (1456/3854,ALSPAC)
G=0359 (1331/3708,TWINSUK)
chr1:162361831 (GRCh38.p7) (1q23.3)
AD
GWASdb2
1   publication(s)
See rs on genome
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 1NC_000001.11:g.162361831A>G
GRCh37.p13 chr 1NC_000001.10:g.162331621A>G
NOS1AP RefSeqGeneNG_015979.1:g.297041A>G

Gene: NOS1AP, nitric oxide synthase 1 adaptor protein(plus strand)

Molecule type Change Amino acid[Codon] SO Term
NOS1AP transcript variant 3NM_001164757.1:c.N/AIntron Variant
NOS1AP transcript variant 1NM_014697.2:c.N/AIntron Variant
NOS1AP transcript variant 2NM_001126060.1:c.N/AGenic Upstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.896G=0.104
1000GenomesAmericanSub694A=0.600G=0.400
1000GenomesEast AsianSub1008A=0.455G=0.545
1000GenomesEuropeSub1006A=0.607G=0.393
1000GenomesGlobalStudy-wide5008A=0.689G=0.311
1000GenomesSouth AsianSub978A=0.790G=0.210
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.622G=0.378
The Genome Aggregation DatabaseAfricanSub8706A=0.880G=0.120
The Genome Aggregation DatabaseAmericanSub834A=0.580G=0.420
The Genome Aggregation DatabaseEast AsianSub1616A=0.478G=0.522
The Genome Aggregation DatabaseEuropeSub18428A=0.610G=0.389
The Genome Aggregation DatabaseGlobalStudy-wide29886A=0.682G=0.317
The Genome Aggregation DatabaseOtherSub302A=0.730G=0.270
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.738G=0.261
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.641G=0.359
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs66819810.00057alcohol dependence20201924

eQTL of rs6681981 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs6681981 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr1162305025162305275E067-26346
chr1162289330162289913E068-41708
chr1162305025162305275E069-26346
chr1162304017162304135E070-27486
chr1162304758162304825E070-26796
chr1162305025162305275E070-26346
chr1162326728162326823E070-4798
chr1162327556162327793E070-3828
chr1162328402162328580E070-3041
chr1162330041162330477E070-1144
chr1162330840162330976E070-645
chr1162331337162331394E070-227
chr1162359750162359829E07028129
chr1162359830162359963E07028209
chr1162359984162360123E07028363
chr1162361609162361953E07029988
chr1162289330162289913E071-41708
chr1162294180162294727E071-36894
chr1162305025162305275E071-26346
chr1162361609162361953E07129988
chr1162304758162304825E072-26796
chr1162305025162305275E072-26346
chr1162361609162361953E07229988
chr1162289330162289913E073-41708
chr1162305025162305275E073-26346
chr1162323642162323776E073-7845
chr1162361609162361953E07329988
chr1162305025162305275E074-26346
chr1162305025162305275E081-26346
chr1162330041162330477E081-1144
chr1162330840162330976E081-645
chr1162298461162298567E082-33054