SNP Detail Info-rs6701037

Organism: Homo sapiens

Alleles: A>C

Gene : Feature

None

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

C=0404 (12064/29860,GnomAD)
C=0359 (10461/29118,TOPMED)
C=0287 (1435/5008,1000G)
C=0464 (1789/3854,ALSPAC)
C=0489 (1812/3708,TWINSUK)

Position: chr1:175150943 (GRCh38.p7) (1q25.1)

Phenotype: AD

Dataset:

GWASdb2 | GWASCatalog

Publications: 6 publication(s)

Genomic View: See rs on genome

Enhancer: 22 Enhancers around

Promoter: 8 Promoters around

Sequence Name	Change(s)
GRCh38.p7 chr 1	NC_000001.11:g.175150943A>C
GRCh37.p13 chr 1	NC_000001.10:g.175120079A>C

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	A=0.680	C=0.320
1000Genomes	American	Sub	694	A=0.690	C=0.310
1000Genomes	East Asian	Sub	1008	A=0.903	C=0.097
1000Genomes	Europe	Sub	1006	A=0.551	C=0.449
1000Genomes	Global	Study-wide	5008	A=0.713	C=0.287
1000Genomes	South Asian	Sub	978	A=0.750	C=0.250
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	A=0.536	C=0.464
The Genome Aggregation Database	African	Sub	8690	A=0.672	C=0.328
The Genome Aggregation Database	American	Sub	836	A=0.740	C=0.260
The Genome Aggregation Database	East Asian	Sub	1612	A=0.899	C=0.101
The Genome Aggregation Database	Europe	Sub	18422	A=0.525	C=0.474
The Genome Aggregation Database	Global	Study-wide	29860	A=0.596	C=0.404
The Genome Aggregation Database	Other	Sub	300	A=0.700	C=0.300
Trans-Omics for Precision Medicine	Global	Study-wide	29118	A=0.640	C=0.359
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	A=0.511	C=0.489

PMID	Title	Author	Journal
21703634	A meta-analysis of two genome-wide association studies identifies 3 new loci for alcohol dependence.	Wang KS	J Psychiatr Res
21956439	Genome-wide association study of alcohol dependence implicates KIAA0040 on chromosome 1q.	Zuo L	Neuropsychopharmacology
20012890	A genome-wide association study of social and non-social autistic-like traits in the general population using pooled DNA, 500 K SNP microarrays and both community and diagnosed autism replication samples.	Ronald A	Behav Genet
23365539	Large scale association analysis for drug addiction: results from SNP to gene.	Guo X	ScientificWorldJournal
20202923	A genome-wide association study of alcohol dependence.	Bierut LJ	Proc Natl Acad Sci U S A
25043041	Neuropsychosocial profiles of current and future adolescent alcohol misusers.	Whelan R	Nature

SNP ID	p-value	Traits	Study
rs6701037	0.0000002	alcohol dependence	21703634
rs6701037	0.00000175	alcohol dependence	20202923
rs6701037	0.00023	alcohol dependence	21956439

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

Chromosome	Start	End	Region	Distance ( -/+ : Up/Downstream )
chr1	175127262	175127638	E067	7183
chr1	175127726	175127793	E067	7647
chr1	175121212	175121706	E069	1133
chr1	175138495	175138718	E069	18416
chr1	175117508	175117593	E070	-2486
chr1	175131566	175131616	E070	11487
chr1	175131702	175131793	E070	11623
chr1	175131845	175132044	E070	11766
chr1	175132208	175132358	E070	12129
chr1	175169465	175169525	E071	49386
chr1	175121212	175121706	E072	1133
chr1	175115170	175115364	E081	-4715
chr1	175115429	175115500	E081	-4579
chr1	175115737	175116333	E081	-3746
chr1	175116438	175116534	E081	-3545
chr1	175116763	175117071	E081	-3008
chr1	175117325	175117401	E081	-2678
chr1	175117508	175117593	E081	-2486
chr1	175120951	175121040	E081	872
chr1	175121212	175121706	E081	1133
chr1	175127262	175127638	E082	7183
chr1	175127726	175127793	E082	7647

Chromosome	Start	End	Region	Distance(-/+:Up/Downstream)
chr1	175160861	175163201	E067	40782
chr1	175160861	175163201	E068	40782
chr1	175160861	175163201	E069	40782
chr1	175160861	175163201	E071	40782
chr1	175160861	175163201	E072	40782
chr1	175160861	175163201	E073	40782
chr1	175160861	175163201	E074	40782
chr1	175160861	175163201	E082	40782

rs6701037