27827401 | Alcohol consumption, genetic variants in the alcohol- and folate metabolic pathways and colorectal cancer risk: the JPHC Study. | Svensson T | Sci Rep |
21455501 | Genetic variants on chromosome 8q24 and colorectal neoplasia risk: a case-control study in China and a meta-analysis of the published literature. | Li M | PLoS One |
21351086 | Shortened telomeres in individuals with abuse in alcohol consumption. | Pavanello S | Int J Cancer |
20010786 | Alcohol dehydrogenase-2 and aldehyde dehydrogenase-2 genotypes, alcohol drinking and the risk for esophageal cancer in a Chinese population. | Ding JH | J Hum Genet |
22010049 | Loci affecting gamma-glutamyl transferase in adults and adolescents show age x SNP interaction and cardiometabolic disease associations. | Middelberg RP | Hum Mol Genet |
27038040 | ADH1B and ALDH2 are associated with metachronous SCC after endoscopic submucosal dissection of esophageal squamous cell carcinoma. | Kagemoto K | Cancer Med |
19698717 | Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal cancer risk. | Cui R | Gastroenterology |
27118149 | Risk and predictors of hepatocellular carcinoma for chronic hepatitis B patients with newly developed cirrhosis. | Chien J | J Gastroenterol Hepatol |
20518787 | Comparison between self-reported facial flushing after alcohol consumption and ALDH2 Glu504Lys polymorphism for risk of upper aerodigestive tract cancer in a Japanese population. | Oze I | Cancer Sci |
26130061 | Aldehyde dehydrogenase 2 genetic variations may increase susceptibility to Parkinson's disease in Han Chinese population. | Zhang X | Neurobiol Aging |
21315679 | Green tea consumption, inflammation and the risk of primary hepatocellular carcinoma in a Chinese population. | Li Y | Cancer Epidemiol |
4065146 | Mitochondrial aldehyde dehydrogenase from human liver. Primary structure, differences in relation to the cytosolic enzyme, and functional correlations. | Hempel J | Eur J Biochem |
25636114 | [Advance in research on the association of ALDH2 gene polymorphisms with cancer susceptibility in drinkers]. | Chen C | Zhonghua Yi Xue Yi Chuan Xue Za Zhi |
10627091 | Hangover symptoms in Asian Americans with variations in the aldehyde dehydrogenase (ALDH2) gene. | Wall TL | J Stud Alcohol |
26356841 | Alcohol Use and Gamma-Glutamyltransferase Using a Mendelian Randomization Design in the Guangzhou Biobank Cohort Study. | Xu L | PLoS One |
25411394 | Genetic alcohol sensitivity regulated by ALDH2 and ADH1B polymorphisms as indicator of mental disorders in Japanese employees. | Yoshimasu K | Alcohol Alcohol |
26364564 | Exploring causal associations of alcohol with cardiovascular and metabolic risk factors in a Chinese population using Mendelian randomization analysis. | Taylor AE | Sci Rep |
27181629 | Identification of rs671, a common variant of ALDH2, as a gout susceptibility locus. | Sakiyama M | Sci Rep |
22560290 | A comparison of Val81Met and other polymorphisms of alcohol metabolising genes in patients and controls in Northern Spain. | Celorrio D | Alcohol |
26770579 | Genetic variants at 6p21, 10q23, 16q21 and 22q12 are associated with esophageal cancer risk in a Chinese Han population. | Jia X | Int J Clin Exp Med |
22004471 | Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster. | Frank J | Addict Biol |
21367945 | Genome-wide association studies of alcohol intake--a promising cocktail? | Agrawal A | Am J Clin Nutr |
26599441 | Association of Genetically Determined Aldehyde Dehydrogenase 2 Activity with Diabetic Complications in Relation to Alcohol Consumption in Japanese Patients with Type 2 Diabetes Mellitus: The Fukuoka Diabetes Registry. | Idewaki Y | PLoS One |
26992901 | Aldehyde dehydrogenase 2 (ALDH2) and alcohol dehydrogenase 1B (ADH1B) polymorphisms exacerbate bladder cancer risk associated with alcohol drinking: gene-environment interaction. | Masaoka H | Carcinogenesis |
21900886 | Pharmacogenetics of naltrexone in asian americans: a randomized placebo-controlled laboratory study. | Ray LA | Neuropsychopharmacology |
21576033 | ADH1B and ALDH2 polymorphisms and their associations with increased risk of squamous cell carcinoma of the head and neck in the Korean population. | Ji YB | Oral Oncol |
22171074 | A genome-wide association and gene-environment interaction study for serum triglycerides levels in a healthy Chinese male population. | Tan A | Hum Mol Genet |
19262484 | Gene-environmental interaction regarding alcohol-metabolizing enzymes in the Japanese general population. | Tsuchihashi-Makaya M | Hypertens Res |
25427900 | Genetic-epidemiological evidence for the role of acetaldehyde in cancers related to alcohol drinking. | Eriksson CJ | Adv Exp Med Biol |
25403981 | Meta-analysis of association between ALDH2 rs671 polymorphism and essential hypertension in Asian populations. | Zhang SY | Herz |
24968322 | Single nucleotide polymorphisms associated with colorectal cancer susceptibility and loss of heterozygosity in a Taiwanese population. | Yang CY | PLoS One |
26174136 | Three missense variants of metabolic syndrome-related genes are associated with alpha-1 antitrypsin levels. | Setoh K | Nat Commun |
21437268 | A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium. | McKay JD | PLoS Genet |
21338875 | Genetic vulnerability and susceptibility to substance dependence. | Bierut LJ | Neuron |
26827895 | Alcohol Drinking Mediates the Association between Polymorphisms of ADH1B and ALDH2 and Hepatitis B-Related Hepatocellular Carcinoma. | Liu J | Cancer Epidemiol Biomarkers Prev |
25313998 | The ALDH2 rs671 polymorphism affects post-stroke epilepsy susceptibility and plasma 4-HNE levels. | Yang H | PLoS One |
15654505 | Association of habitual smoking and drinking with single nucleotide polymorphism (SNP) in 40 candidate genes: data from random population-based Japanese samples. | Liu Y | J Hum Genet |
22839215 | Common ALDH2 genetic variants predict development of hypertension in the SAPPHIRe prospective cohort: gene-environmental interaction with alcohol consumption. | Chang YC | BMC Cardiovasc Disord |
19041386 | Genetic-epidemiological evidence on genes associated with HDL cholesterol levels: a systematic in-depth review. | Boes E | Exp Gerontol |
20585100 | Genome-wide association studies of cancer. | Stadler ZK | J Clin Oncol |
20417517 | The ALDH2 Glu504Lys polymorphism is associated with coronary artery disease in Han Chinese: Relation with endothelial ADMA levels. | Guo YJ | Atherosclerosis |
22507220 | Epidemiologic differences in esophageal cancer between Asian and Western populations. | Zhang HZ | Chin J Cancer |
25803854 | Genotyping on ALDH2: comparison of four different technologies. | Zhang L | PLoS One |
2987944 | Cloning of cDNAs for human aldehyde dehydrogenases 1 and 2. | Hsu LC | Proc Natl Acad Sci U S A |
18331377 | Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) sample. | Kuo PH | Alcohol Clin Exp Res |
20093384 | Impact of smoking on lung cancer risk is stronger in those with the homozygous aldehyde dehydrogenase 2 null allele in a Japanese population. | Park JY | Carcinogenesis |
22102315 | Strong protective effect of the aldehyde dehydrogenase gene (ALDH2) 504lys (*2) allele against alcoholism and alcohol-induced medical diseases in Asians. | Li D | Hum Genet |
21946912 | Folate, alcohol, and aldehyde dehydrogenase 2 polymorphism and the risk of oral and pharyngeal cancer in Japanese. | Matsuo K | Eur J Cancer Prev |
25047496 | Synergistic association between two alcohol metabolism relevant genes and coronary artery disease among Chinese hypertensive patients. | Wang Y | PLoS One |
21917409 | Alcohol drinking, mean corpuscular volume of erythrocytes, and alcohol metabolic genotypes in drunk drivers. | Pavanello S | Alcohol |
27588484 | Gene-gene interactions in gastrointestinal cancer susceptibility. | Kim J | Oncotarget |
20100738 | Prevalence and persistence of chromosomal damage and susceptible genotypes of metabolic and DNA repair genes in Chinese vinyl chloride-exposed workers. | Ji F | Carcinogenesis |
20616999 | Usefulness of Mendelian randomization in observational epidemiology. | Bochud M | Int J Environ Res Public Health |
18056758 | Major genetic components underlying alcoholism in Korean population. | Kim DJ | Hum Mol Genet |
27453488 | Aldehyde dehydrogenase 2 is associated with cognitive functions in patients with Parkinson's disease. | Yu RL | Sci Rep |
22551939 | Association of a functional single-nucleotide polymorphism in the ALDH2 gene with essential hypertension depends on drinking behavior in a Chinese Han population. | Wang Y | J Hum Hypertens |
21083667 | Haplotype-based study of the association of alcohol-metabolizing genes with alcohol dependence in four independent populations. | Liu J | Alcohol Clin Exp Res |
27986911 | Aldehyde Dehydrogenase 2 Polymorphism Is a Predictor of Smoking Cessation. | Masaoka H | Nicotine Tob Res |
26687910 | Alcohol intake and cardiovascular risk factors: A Mendelian randomisation study. | Cho Y | Sci Rep |
22806211 | The genetics of addiction-a translational perspective. | Agrawal A | Transl Psychiatry |
22301922 | Measuring alcohol consumption for genomic meta-analyses of alcohol intake: opportunities and challenges. | Agrawal A | Am J Clin Nutr |
22675424 | ADH1C Ile350Val polymorphism and cancer risk: evidence from 35 case-control studies. | Xue Y | PLoS One |
8903321 | The mutation in the mitochondrial aldehyde dehydrogenase (ALDH2) gene responsible for alcohol-induced flushing increases turnover of the enzyme tetramers in a dominant fashion. | Xiao Q | J Clin Invest |
21926110 | Population-specific genetic associations with oesophageal squamous cell carcinoma in South Africa. | Bye H | Carcinogenesis |
26125444 | Family history of cancer and the risk of squamous cell carcinoma of oesophagus: a case-control study in Kashmir, India. | Bhat GA | Br J Cancer |
20505153 | A compendium of genome-wide associations for cancer: critical synopsis and reappraisal. | Ioannidis JP | J Natl Cancer Inst |
27191745 | Aldehyde dehydrogenase 2 inhibits inflammatory response and regulates atherosclerotic plaque. | Pan C | Oncotarget |
21467728 | Profile of participants and genotype distributions of 108 polymorphisms in a cross-sectional study of associations of genotypes with lifestyle and clinical factors: a project in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. | Wakai K | J Epidemiol |
22004425 | Genetic risk of hepatocellular carcinoma in patients with hepatitis C virus: a case control study. | Tomoda T | J Gastroenterol Hepatol |
23685282 | Association of genetic polymorphisms in ADH and ALDH2 with risk of coronary artery disease and myocardial infarction: a meta-analysis. | Han H | Gene |
21372407 | Confirmation of ALDH2 as a Major locus of drinking behavior and of its variants regulating multiple metabolic phenotypes in a Japanese population. | Takeuchi F | Circ J |
27437086 | Allele Frequencies of the Single Nucleotide Polymorphisms Related to the Body Burden of Heavy Metals in the Korean Population and Their Ethnic Differences. | Eom SY | Toxicol Res |
16046871 | Hangover susceptibility in relation to aldehyde dehydrogenase-2 genotype, alcohol flushing, and mean corpuscular volume in Japanese workers. | Yokoyama M | Alcohol Clin Exp Res |
27991683 | Platelet Counts and Genetic Polymorphisms of Alcohol Dehydrogenase-1B and Aldehyde Dehydrogenase-2 in Japanese Alcoholic Men. | Yokoyama A | Alcohol Clin Exp Res |
10780266 | Involvement of acetaldehyde for full protection against alcoholism by homozygosity of the variant allele of mitochondrial aldehyde dehydrogenase gene in Asians. | Peng GS | Pharmacogenetics |
22508505 | Aldehyde-stress resulting from Aldh2 mutation promotes osteoporosis due to impaired osteoblastogenesis. | Hoshi H | J Bone Miner Res |
19706845 | A novel polymorphism rs1329149 of CYP2E1 and a known polymorphism rs671 of ALDH2 of alcohol metabolizing enzymes are associated with colorectal cancer in a southwestern Chinese population. | Yang H | Cancer Epidemiol Biomarkers Prev |
26848030 | Effects of Obesity Related Genetic Variations on Visceral and Subcutaneous Fat Distribution in a Chinese Population. | Wang T | Sci Rep |
19826048 | Candidate gene association study of esophageal squamous cell carcinoma in a high-risk region in Iran. | Akbari MR | Cancer Res |
24861553 | Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index. | Wen W | Hum Mol Genet |
21971053 | Genome-wide association study of coronary artery disease in the Japanese. | Takeuchi F | Eur J Hum Genet |
23629646 | Epidemiology of esophageal cancer in Japan and China. | Lin Y | J Epidemiol |
22640768 | The genetic basis of addictive disorders. | Ducci F | Psychiatr Clin North Am |
23697560 | ALDH2 rs671 Polymorphism and coronary heart disease risk among Asian populations: a meta-analysis and meta-regression. | Wang Q | DNA Cell Biol |
16440063 | Mitochondrial aldehyde dehydrogenase-2 (ALDH2) Glu504Lys polymorphism contributes to the variation in efficacy of sublingual nitroglycerin. | Li Y | J Clin Invest |
23455379 | The aldehyde dehydrogenase 2 (ALDH2) Glu504Lys polymorphism interacts with alcohol drinking in the risk of stomach cancer. | Matsuo K | Carcinogenesis |
27927211 | Genetic variations of aldehyde dehydrogenase 2 and alcohol dehydrogenase 1B are associated with the etiology of atrial fibrillation in Japanese. | Nakano Y | J Biomed Sci |
19430479 | Genome-wide association study of blood pressure and hypertension. | Levy D | Nat Genet |
26284938 | Alcohol Dehydrogenase-1B (rs1229984) and Aldehyde Dehydrogenase-2 (rs671) Genotypes Are Strong Determinants of the Serum Triglyceride and Cholesterol Levels of Japanese Alcoholic Men. | Yokoyama A | PLoS One |
26954674 | Alteration of Antiviral Signalling by Single Nucleotide Polymorphisms (SNPs) of Mitochondrial Antiviral Signalling Protein (MAVS). | Xing F | PLoS One |
25045619 | The Genetics, Neurogenetics and Pharmacogenetics of Addiction. | Demers CH | Curr Behav Neurosci Rep |
26995653 | Impacts of common variants in ALDH2 on coronary artery disease patients. | Zhao J | Gene |
28212632 | Exome-wide association study identifies genetic polymorphisms of C12orf51, MYL2, and ALDH2 associated with blood lead levels in the general Korean population. | Eom SY | Environ Health |
22930414 | Single nucleotide polymorphisms of ADH1B, ADH1C and ALDH2 genes and esophageal cancer: a population-based case-control study in China. | Wu M | Int J Cancer |
18996923 | Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis. | Macgregor S | Hum Mol Genet |
28371326 | Susceptibility loci for metabolic syndrome and metabolic components identified in Han Chinese: a multi-stage genome-wide association study. | Zhu Y | J Cell Mol Med |
22865593 | Distinct genetic association at the PLCE1 locus with oesophageal squamous cell carcinoma in the South African population. | Bye H | Carcinogenesis |
23243119 | Is aldehyde dehydrogenase 2 a credible genetic instrument for alcohol use in Mendelian randomization analysis in Southern Chinese men? | Au Yeung SL | Int J Epidemiol |
23088731 | Tag single nucleotide polymorphisms of alcohol-metabolizing enzymes modify the risk of upper aerodigestive tract cancers: HapMap database analysis. | Chung CS | Dis Esophagus |
24037726 | Variant ALDH2 is associated with accelerated progression of bone marrow failure in Japanese Fanconi anemia patients. | Hira A | Blood |
16595073 | Functional nsSNPs from carcinogenesis-related genes expressed in breast tissue: potential breast cancer risk alleles and their distribution across human populations. | Savas S | Hum Genomics |
26891264 | No Interaction with Alcohol Consumption, but Independent Effect of C12orf51 (HECTD4) on Type 2 Diabetes Mellitus in Korean Adults Aged 40-69 Years: The KoGES_Ansan and Ansung Study. | Kim J | PLoS One |
6582480 | Molecular abnormality of an inactive aldehyde dehydrogenase variant commonly found in Orientals. | Yoshida A | Proc Natl Acad Sci U S A |
20729852 | A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma. | Abnet CC | Nat Genet |
20833657 | Strong interaction between the effects of alcohol consumption and smoking on oesophageal squamous cell carcinoma among individuals with ADH1B and/or ALDH2 risk alleles. | Tanaka F | Gut |
24277619 | ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample. | Quillen EE | Am J Med Genet B Neuropsychiatr Genet |
23072573 | Multiplex allele-specific amplification from whole blood for detecting multiple polymorphisms simultaneously. | Zhu J | Genet Test Mol Biomarkers |
23430454 | Genetic variants at 4q21, 4q23 and 12q24 are associated with esophageal squamous cell carcinoma risk in a Chinese population. | Gao Y | Hum Genet |
7593603 | The aldehyde dehydrogenase ALDH2*2 allele exhibits dominance over ALDH2*1 in transduced HeLa cells. | Xiao Q | J Clin Invest |
26833210 | Evaluation of pleiotropic effects among common genetic loci identified for cardio-metabolic traits in a Korean population. | Kim YK | Cardiovasc Diabetol |
7180842 | Structural mutation in a major human aldehyde dehydrogenase gene results in loss of enzyme activity. | Impraim C | Am J Hum Genet |
25133033 | Epidemiological studies of esophageal cancer in the era of genome-wide association studies. | Wang AH | World J Gastrointest Pathophysiol |
23969552 | Blood ethanol levels of nonabstinent Japanese alcoholic men in the morning after drinking and their ADH1B and ALDH2 genotypes. | Yokoyama A | Alcohol Alcohol |
19641380 | Candidate gene polymorphisms for diabetes mellitus, cardiovascular disease and cancer are associated with longevity in Koreans. | Park JW | Exp Mol Med |
26785701 | Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference. | Wen W | Sci Rep |
17885622 | Pharmacokinetic and pharmacodynamic basis for partial protection against alcoholism in Asians, heterozygous for the variant ALDH2*2 gene allele. | Peng GS | Pharmacogenet Genomics |
23364009 | Common variants at 12q24 are associated with drinking behavior in Han Chinese. | Yang X | Am J Clin Nutr |
21572416 | Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians. | Kato N | Nat Genet |
23555315 | Genome-wide testing of putative functional exonic variants in relationship with breast and prostate cancer risk in a multiethnic population. | Haiman CA | PLoS Genet |
18317873 | Statistical analysis of the associations between polymorphisms within aldehyde dehydrogenase 2 (ALDH2), and quantitative and qualitative traits extracted from a large-scale database of Japanese single-nucleotide polymorphisms (SNPs). | Nose J | J Hum Genet |
20981351 | Promoter Polymorphism of RGS2 Gene Is Associated with Change of Blood Pressure in Subjects with Antihypertensive Treatment: The Azelnidipine and Temocapril in Hypertensive Patients with Type 2 Diabetes Study. | Sugimoto K | Int J Hypertens |
25680115 | Association between Glu504Lys polymorphism of ALDH2 gene and cancer risk: a meta-analysis. | Cai Q | PLoS One |
24652602 | Alcohol consumption and lifetime change in cognitive ability: a gene x environment interaction study. | Ritchie SJ | Age (Dordr) |
25573768 | Effects of genetic variants of ADH1B and ALDH2 and social network on continued alcohol drinking among young adolescents in Taiwan. | Ting TT | Drug Alcohol Depend |
26542604 | Alcohol Dehydrogenase-1B (rs1229984) and Aldehyde Dehydrogenase-2 (rs671) Genotypes and Alcoholic Ketosis Are Associated with the Serum Uric Acid Level in Japanese Alcoholic Men. | Yokoyama A | Alcohol Alcohol |
26825972 | Relationships of alcohol dehydrogenase 1B (ADH1B) and aldehyde dehydrogenase 2 (ALDH2) genotypes with alcohol sensitivity, drinking behavior and problem drinking in Japanese older men. | Hashimoto M | Environ Health Prev Med |
24274136 | Biobanking across the phenome - at the center of chronic disease research. | Imboden M | BMC Public Health |
27294413 | Human genome meeting 2016 : Houston, TX, USA. 28 February - 2 March 2016. | - | Hum Genomics |
24633362 | ALDH2 and ADH1 genetic polymorphisms may contribute to the risk of gastric cancer: a meta-analysis. | Wang HL | PLoS One |
25543168 | Genetic alcohol sensitivity regulated by ALDH2 and ADH1B polymorphisms is strongly associated with depression and anxiety in Japanese employees. | Yoshimasu K | Drug Alcohol Depend |
22674868 | Genetic variants at 4q23 and 12q24 are associated with head and neck cancer risk in China. | Yuan H | Mol Carcinog |