rs671

Homo sapiens
G>A
ALDH2 : Missense Variant
Check p-value
SNV (Single Nucleotide Variation)
A=0021 (1878/88224,ExAC)
A=0014 (434/29938,GnomAD)
A=0000 (11/29118,TOPMED)
A=0036 (179/5008,1000G)
A=0001 (4/3854,ALSPAC)
A=0000 (0/3708,TWINSUK)
chr12:111803962 (GRCh38.p7) (12q24.12)
AD
GWASdb2 | GWASCatalog
See rs on genome

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 12NC_000012.12:g.111803962G>A
GRCh37.p13 chr 12NC_000012.11:g.112241766G>A
ALDH2 RefSeqGeneNG_012250.1:g.42421G>A

Gene: ALDH2, aldehyde dehydrogenase 2 family (mitochondrial)(plus strand)

Molecule type Change Amino acid[Codon] SO Term
ALDH2 transcript variant 1NM_000690.3:c.151...NM_000690.3:c.1510G>AE [GAA]> K [AAA]Coding Sequence Variant
aldehyde dehydrogenase, mitochondrial isoform 1 precursorNP_000681.2:p.Glu...NP_000681.2:p.Glu504LysE [Glu]> K [Lys]Missense Variant
ALDH2 transcript variant 2NM_001204889.1:c....NM_001204889.1:c.1369G>AE [GAA]> K [AAA]Coding Sequence Variant
aldehyde dehydrogenase, mitochondrial isoform 2 precursorNP_001191818.1:p....NP_001191818.1:p.Glu457LysE [Glu]> K [Lys]Missense Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.998A=0.002
1000GenomesAmericanSub694G=1.000A=0.000
1000GenomesEast AsianSub1008G=0.826A=0.174
1000GenomesEuropeSub1006G=1.000A=0.000
1000GenomesGlobalStudy-wide5008G=0.964A=0.036
1000GenomesSouth AsianSub978G=1.000A=0.000
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.999A=0.001
The Exome Aggregation ConsortiumAmericanSub14916G=0.999A=0.000
The Exome Aggregation ConsortiumAsianSub19698G=0.905A=0.094
The Exome Aggregation ConsortiumEuropeSub52942G=0.999A=0.000
The Exome Aggregation ConsortiumGlobalStudy-wide88224G=0.978A=0.021
The Exome Aggregation ConsortiumOtherSub668G=1.000A=0.000
The Genome Aggregation DatabaseAfricanSub8706G=1.000A=0.000
The Genome Aggregation DatabaseAmericanSub838G=1.000A=0.000
The Genome Aggregation DatabaseEast AsianSub1608G=0.733A=0.267
The Genome Aggregation DatabaseEuropeSub18484G=0.999A=0.000
The Genome Aggregation DatabaseGlobalStudy-wide29938G=0.985A=0.014
The Genome Aggregation DatabaseOtherSub302G=1.000A=0.000
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.999A=0.000
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=1.000A=0.000
PMID Title Author Journal
27827401Alcohol consumption, genetic variants in the alcohol- and folate metabolic pathways and colorectal cancer risk: the JPHC Study.Svensson TSci Rep
21455501Genetic variants on chromosome 8q24 and colorectal neoplasia risk: a case-control study in China and a meta-analysis of the published literature.Li MPLoS One
21351086Shortened telomeres in individuals with abuse in alcohol consumption.Pavanello SInt J Cancer
20010786Alcohol dehydrogenase-2 and aldehyde dehydrogenase-2 genotypes, alcohol drinking and the risk for esophageal cancer in a Chinese population.Ding JHJ Hum Genet
22010049Loci affecting gamma-glutamyl transferase in adults and adolescents show age x SNP interaction and cardiometabolic disease associations.Middelberg RPHum Mol Genet
27038040ADH1B and ALDH2 are associated with metachronous SCC after endoscopic submucosal dissection of esophageal squamous cell carcinoma.Kagemoto KCancer Med
19698717Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal cancer risk.Cui RGastroenterology
27118149Risk and predictors of hepatocellular carcinoma for chronic hepatitis B patients with newly developed cirrhosis.Chien JJ Gastroenterol Hepatol
20518787Comparison between self-reported facial flushing after alcohol consumption and ALDH2 Glu504Lys polymorphism for risk of upper aerodigestive tract cancer in a Japanese population.Oze ICancer Sci
26130061Aldehyde dehydrogenase 2 genetic variations may increase susceptibility to Parkinson's disease in Han Chinese population.Zhang XNeurobiol Aging
21315679Green tea consumption, inflammation and the risk of primary hepatocellular carcinoma in a Chinese population.Li YCancer Epidemiol
4065146Mitochondrial aldehyde dehydrogenase from human liver. Primary structure, differences in relation to the cytosolic enzyme, and functional correlations.Hempel JEur J Biochem
25636114[Advance in research on the association of ALDH2 gene polymorphisms with cancer susceptibility in drinkers].Chen CZhonghua Yi Xue Yi Chuan Xue Za Zhi
10627091Hangover symptoms in Asian Americans with variations in the aldehyde dehydrogenase (ALDH2) gene.Wall TLJ Stud Alcohol
26356841Alcohol Use and Gamma-Glutamyltransferase Using a Mendelian Randomization Design in the Guangzhou Biobank Cohort Study.Xu LPLoS One
25411394Genetic alcohol sensitivity regulated by ALDH2 and ADH1B polymorphisms as indicator of mental disorders in Japanese employees.Yoshimasu KAlcohol Alcohol
26364564Exploring causal associations of alcohol with cardiovascular and metabolic risk factors in a Chinese population using Mendelian randomization analysis.Taylor AESci Rep
27181629Identification of rs671, a common variant of ALDH2, as a gout susceptibility locus.Sakiyama MSci Rep
22560290A comparison of Val81Met and other polymorphisms of alcohol metabolising genes in patients and controls in Northern Spain.Celorrio DAlcohol
26770579Genetic variants at 6p21, 10q23, 16q21 and 22q12 are associated with esophageal cancer risk in a Chinese Han population.Jia XInt J Clin Exp Med
22004471Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster.Frank JAddict Biol
21367945Genome-wide association studies of alcohol intake--a promising cocktail?Agrawal AAm J Clin Nutr
26599441Association of Genetically Determined Aldehyde Dehydrogenase 2 Activity with Diabetic Complications in Relation to Alcohol Consumption in Japanese Patients with Type 2 Diabetes Mellitus: The Fukuoka Diabetes Registry.Idewaki YPLoS One
26992901Aldehyde dehydrogenase 2 (ALDH2) and alcohol dehydrogenase 1B (ADH1B) polymorphisms exacerbate bladder cancer risk associated with alcohol drinking: gene-environment interaction.Masaoka HCarcinogenesis
21900886Pharmacogenetics of naltrexone in asian americans: a randomized placebo-controlled laboratory study.Ray LANeuropsychopharmacology
21576033ADH1B and ALDH2 polymorphisms and their associations with increased risk of squamous cell carcinoma of the head and neck in the Korean population.Ji YBOral Oncol
22171074A genome-wide association and gene-environment interaction study for serum triglycerides levels in a healthy Chinese male population.Tan AHum Mol Genet
19262484Gene-environmental interaction regarding alcohol-metabolizing enzymes in the Japanese general population.Tsuchihashi-Makaya MHypertens Res
25427900Genetic-epidemiological evidence for the role of acetaldehyde in cancers related to alcohol drinking.Eriksson CJAdv Exp Med Biol
25403981Meta-analysis of association between ALDH2 rs671 polymorphism and essential hypertension in Asian populations.Zhang SYHerz
24968322Single nucleotide polymorphisms associated with colorectal cancer susceptibility and loss of heterozygosity in a Taiwanese population.Yang CYPLoS One
26174136Three missense variants of metabolic syndrome-related genes are associated with alpha-1 antitrypsin levels.Setoh KNat Commun
21437268A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium.McKay JDPLoS Genet
21338875Genetic vulnerability and susceptibility to substance dependence.Bierut LJNeuron
26827895Alcohol Drinking Mediates the Association between Polymorphisms of ADH1B and ALDH2 and Hepatitis B-Related Hepatocellular Carcinoma.Liu JCancer Epidemiol Biomarkers Prev
25313998The ALDH2 rs671 polymorphism affects post-stroke epilepsy susceptibility and plasma 4-HNE levels.Yang HPLoS One
15654505Association of habitual smoking and drinking with single nucleotide polymorphism (SNP) in 40 candidate genes: data from random population-based Japanese samples.Liu YJ Hum Genet
22839215Common ALDH2 genetic variants predict development of hypertension in the SAPPHIRe prospective cohort: gene-environmental interaction with alcohol consumption.Chang YCBMC Cardiovasc Disord
19041386Genetic-epidemiological evidence on genes associated with HDL cholesterol levels: a systematic in-depth review.Boes EExp Gerontol
20585100Genome-wide association studies of cancer.Stadler ZKJ Clin Oncol
20417517The ALDH2 Glu504Lys polymorphism is associated with coronary artery disease in Han Chinese: Relation with endothelial ADMA levels.Guo YJAtherosclerosis
22507220Epidemiologic differences in esophageal cancer between Asian and Western populations.Zhang HZChin J Cancer
25803854Genotyping on ALDH2: comparison of four different technologies.Zhang LPLoS One
2987944Cloning of cDNAs for human aldehyde dehydrogenases 1 and 2.Hsu LCProc Natl Acad Sci U S A
18331377Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) sample.Kuo PHAlcohol Clin Exp Res
20093384Impact of smoking on lung cancer risk is stronger in those with the homozygous aldehyde dehydrogenase 2 null allele in a Japanese population.Park JYCarcinogenesis
22102315Strong protective effect of the aldehyde dehydrogenase gene (ALDH2) 504lys (*2) allele against alcoholism and alcohol-induced medical diseases in Asians.Li DHum Genet
21946912Folate, alcohol, and aldehyde dehydrogenase 2 polymorphism and the risk of oral and pharyngeal cancer in Japanese.Matsuo KEur J Cancer Prev
25047496Synergistic association between two alcohol metabolism relevant genes and coronary artery disease among Chinese hypertensive patients.Wang YPLoS One
21917409Alcohol drinking, mean corpuscular volume of erythrocytes, and alcohol metabolic genotypes in drunk drivers.Pavanello SAlcohol
27588484Gene-gene interactions in gastrointestinal cancer susceptibility.Kim JOncotarget
20100738Prevalence and persistence of chromosomal damage and susceptible genotypes of metabolic and DNA repair genes in Chinese vinyl chloride-exposed workers.Ji FCarcinogenesis
20616999Usefulness of Mendelian randomization in observational epidemiology.Bochud MInt J Environ Res Public Health
18056758Major genetic components underlying alcoholism in Korean population.Kim DJHum Mol Genet
27453488Aldehyde dehydrogenase 2 is associated with cognitive functions in patients with Parkinson's disease.Yu RLSci Rep
22551939Association of a functional single-nucleotide polymorphism in the ALDH2 gene with essential hypertension depends on drinking behavior in a Chinese Han population.Wang YJ Hum Hypertens
21083667Haplotype-based study of the association of alcohol-metabolizing genes with alcohol dependence in four independent populations.Liu JAlcohol Clin Exp Res
27986911Aldehyde Dehydrogenase 2 Polymorphism Is a Predictor of Smoking Cessation.Masaoka HNicotine Tob Res
26687910Alcohol intake and cardiovascular risk factors: A Mendelian randomisation study.Cho YSci Rep
22806211The genetics of addiction-a translational perspective.Agrawal ATransl Psychiatry
22301922Measuring alcohol consumption for genomic meta-analyses of alcohol intake: opportunities and challenges.Agrawal AAm J Clin Nutr
22675424ADH1C Ile350Val polymorphism and cancer risk: evidence from 35 case-control studies.Xue YPLoS One
8903321The mutation in the mitochondrial aldehyde dehydrogenase (ALDH2) gene responsible for alcohol-induced flushing increases turnover of the enzyme tetramers in a dominant fashion.Xiao QJ Clin Invest
21926110Population-specific genetic associations with oesophageal squamous cell carcinoma in South Africa.Bye HCarcinogenesis
26125444Family history of cancer and the risk of squamous cell carcinoma of oesophagus: a case-control study in Kashmir, India.Bhat GABr J Cancer
20505153A compendium of genome-wide associations for cancer: critical synopsis and reappraisal.Ioannidis JPJ Natl Cancer Inst
27191745Aldehyde dehydrogenase 2 inhibits inflammatory response and regulates atherosclerotic plaque.Pan COncotarget
21467728Profile of participants and genotype distributions of 108 polymorphisms in a cross-sectional study of associations of genotypes with lifestyle and clinical factors: a project in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study.Wakai KJ Epidemiol
22004425Genetic risk of hepatocellular carcinoma in patients with hepatitis C virus: a case control study.Tomoda TJ Gastroenterol Hepatol
23685282Association of genetic polymorphisms in ADH and ALDH2 with risk of coronary artery disease and myocardial infarction: a meta-analysis.Han HGene
21372407Confirmation of ALDH2 as a Major locus of drinking behavior and of its variants regulating multiple metabolic phenotypes in a Japanese population.Takeuchi FCirc J
27437086Allele Frequencies of the Single Nucleotide Polymorphisms Related to the Body Burden of Heavy Metals in the Korean Population and Their Ethnic Differences.Eom SYToxicol Res
16046871Hangover susceptibility in relation to aldehyde dehydrogenase-2 genotype, alcohol flushing, and mean corpuscular volume in Japanese workers.Yokoyama MAlcohol Clin Exp Res
27991683Platelet Counts and Genetic Polymorphisms of Alcohol Dehydrogenase-1B and Aldehyde Dehydrogenase-2 in Japanese Alcoholic Men.Yokoyama AAlcohol Clin Exp Res
10780266Involvement of acetaldehyde for full protection against alcoholism by homozygosity of the variant allele of mitochondrial aldehyde dehydrogenase gene in Asians.Peng GSPharmacogenetics
22508505Aldehyde-stress resulting from Aldh2 mutation promotes osteoporosis due to impaired osteoblastogenesis.Hoshi HJ Bone Miner Res
19706845A novel polymorphism rs1329149 of CYP2E1 and a known polymorphism rs671 of ALDH2 of alcohol metabolizing enzymes are associated with colorectal cancer in a southwestern Chinese population.Yang HCancer Epidemiol Biomarkers Prev
26848030Effects of Obesity Related Genetic Variations on Visceral and Subcutaneous Fat Distribution in a Chinese Population.Wang TSci Rep
19826048Candidate gene association study of esophageal squamous cell carcinoma in a high-risk region in Iran.Akbari MRCancer Res
24861553Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.Wen WHum Mol Genet
21971053Genome-wide association study of coronary artery disease in the Japanese.Takeuchi FEur J Hum Genet
23629646Epidemiology of esophageal cancer in Japan and China.Lin YJ Epidemiol
22640768The genetic basis of addictive disorders.Ducci FPsychiatr Clin North Am
23697560ALDH2 rs671 Polymorphism and coronary heart disease risk among Asian populations: a meta-analysis and meta-regression.Wang QDNA Cell Biol
16440063Mitochondrial aldehyde dehydrogenase-2 (ALDH2) Glu504Lys polymorphism contributes to the variation in efficacy of sublingual nitroglycerin.Li YJ Clin Invest
23455379The aldehyde dehydrogenase 2 (ALDH2) Glu504Lys polymorphism interacts with alcohol drinking in the risk of stomach cancer.Matsuo KCarcinogenesis
27927211Genetic variations of aldehyde dehydrogenase 2 and alcohol dehydrogenase 1B are associated with the etiology of atrial fibrillation in Japanese.Nakano YJ Biomed Sci
19430479Genome-wide association study of blood pressure and hypertension.Levy DNat Genet
26284938Alcohol Dehydrogenase-1B (rs1229984) and Aldehyde Dehydrogenase-2 (rs671) Genotypes Are Strong Determinants of the Serum Triglyceride and Cholesterol Levels of Japanese Alcoholic Men.Yokoyama APLoS One
26954674Alteration of Antiviral Signalling by Single Nucleotide Polymorphisms (SNPs) of Mitochondrial Antiviral Signalling Protein (MAVS).Xing FPLoS One
25045619The Genetics, Neurogenetics and Pharmacogenetics of Addiction.Demers CHCurr Behav Neurosci Rep
26995653Impacts of common variants in ALDH2 on coronary artery disease patients.Zhao JGene
28212632Exome-wide association study identifies genetic polymorphisms of C12orf51, MYL2, and ALDH2 associated with blood lead levels in the general Korean population.Eom SYEnviron Health
22930414Single nucleotide polymorphisms of ADH1B, ADH1C and ALDH2 genes and esophageal cancer: a population-based case-control study in China.Wu MInt J Cancer
18996923Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis.Macgregor SHum Mol Genet
28371326Susceptibility loci for metabolic syndrome and metabolic components identified in Han Chinese: a multi-stage genome-wide association study.Zhu YJ Cell Mol Med
22865593Distinct genetic association at the PLCE1 locus with oesophageal squamous cell carcinoma in the South African population.Bye HCarcinogenesis
23243119Is aldehyde dehydrogenase 2 a credible genetic instrument for alcohol use in Mendelian randomization analysis in Southern Chinese men?Au Yeung SLInt J Epidemiol
23088731Tag single nucleotide polymorphisms of alcohol-metabolizing enzymes modify the risk of upper aerodigestive tract cancers: HapMap database analysis.Chung CSDis Esophagus
24037726Variant ALDH2 is associated with accelerated progression of bone marrow failure in Japanese Fanconi anemia patients.Hira ABlood
16595073Functional nsSNPs from carcinogenesis-related genes expressed in breast tissue: potential breast cancer risk alleles and their distribution across human populations.Savas SHum Genomics
26891264No Interaction with Alcohol Consumption, but Independent Effect of C12orf51 (HECTD4) on Type 2 Diabetes Mellitus in Korean Adults Aged 40-69 Years: The KoGES_Ansan and Ansung Study.Kim JPLoS One
6582480Molecular abnormality of an inactive aldehyde dehydrogenase variant commonly found in Orientals.Yoshida AProc Natl Acad Sci U S A
20729852A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma.Abnet CCNat Genet
20833657Strong interaction between the effects of alcohol consumption and smoking on oesophageal squamous cell carcinoma among individuals with ADH1B and/or ALDH2 risk alleles.Tanaka FGut
24277619ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.Quillen EEAm J Med Genet B Neuropsychiatr Genet
23072573Multiplex allele-specific amplification from whole blood for detecting multiple polymorphisms simultaneously.Zhu JGenet Test Mol Biomarkers
23430454Genetic variants at 4q21, 4q23 and 12q24 are associated with esophageal squamous cell carcinoma risk in a Chinese population.Gao YHum Genet
7593603The aldehyde dehydrogenase ALDH2*2 allele exhibits dominance over ALDH2*1 in transduced HeLa cells.Xiao QJ Clin Invest
26833210Evaluation of pleiotropic effects among common genetic loci identified for cardio-metabolic traits in a Korean population.Kim YKCardiovasc Diabetol
7180842Structural mutation in a major human aldehyde dehydrogenase gene results in loss of enzyme activity.Impraim CAm J Hum Genet
25133033Epidemiological studies of esophageal cancer in the era of genome-wide association studies.Wang AHWorld J Gastrointest Pathophysiol
23969552Blood ethanol levels of nonabstinent Japanese alcoholic men in the morning after drinking and their ADH1B and ALDH2 genotypes.Yokoyama AAlcohol Alcohol
19641380Candidate gene polymorphisms for diabetes mellitus, cardiovascular disease and cancer are associated with longevity in Koreans.Park JWExp Mol Med
26785701Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference.Wen WSci Rep
17885622Pharmacokinetic and pharmacodynamic basis for partial protection against alcoholism in Asians, heterozygous for the variant ALDH2*2 gene allele.Peng GSPharmacogenet Genomics
23364009Common variants at 12q24 are associated with drinking behavior in Han Chinese.Yang XAm J Clin Nutr
21572416Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.Kato NNat Genet
23555315Genome-wide testing of putative functional exonic variants in relationship with breast and prostate cancer risk in a multiethnic population.Haiman CAPLoS Genet
18317873Statistical analysis of the associations between polymorphisms within aldehyde dehydrogenase 2 (ALDH2), and quantitative and qualitative traits extracted from a large-scale database of Japanese single-nucleotide polymorphisms (SNPs).Nose JJ Hum Genet
20981351Promoter Polymorphism of RGS2 Gene Is Associated with Change of Blood Pressure in Subjects with Antihypertensive Treatment: The Azelnidipine and Temocapril in Hypertensive Patients with Type 2 Diabetes Study.Sugimoto KInt J Hypertens
25680115Association between Glu504Lys polymorphism of ALDH2 gene and cancer risk: a meta-analysis.Cai QPLoS One
24652602Alcohol consumption and lifetime change in cognitive ability: a gene x environment interaction study.Ritchie SJAge (Dordr)
25573768Effects of genetic variants of ADH1B and ALDH2 and social network on continued alcohol drinking among young adolescents in Taiwan.Ting TTDrug Alcohol Depend
26542604Alcohol Dehydrogenase-1B (rs1229984) and Aldehyde Dehydrogenase-2 (rs671) Genotypes and Alcoholic Ketosis Are Associated with the Serum Uric Acid Level in Japanese Alcoholic Men.Yokoyama AAlcohol Alcohol
26825972Relationships of alcohol dehydrogenase 1B (ADH1B) and aldehyde dehydrogenase 2 (ALDH2) genotypes with alcohol sensitivity, drinking behavior and problem drinking in Japanese older men.Hashimoto MEnviron Health Prev Med
24274136Biobanking across the phenome - at the center of chronic disease research.Imboden MBMC Public Health
27294413Human genome meeting 2016 : Houston, TX, USA. 28 February - 2 March 2016.-Hum Genomics
24633362ALDH2 and ADH1 genetic polymorphisms may contribute to the risk of gastric cancer: a meta-analysis.Wang HLPLoS One
25543168Genetic alcohol sensitivity regulated by ALDH2 and ADH1B polymorphisms is strongly associated with depression and anxiety in Japanese employees.Yoshimasu KDrug Alcohol Depend
22674868Genetic variants at 4q23 and 12q24 are associated with head and neck cancer risk in China.Yuan HMol Carcinog

P-Value

SNP ID p-value Traits Study
rs6716.32E-86alcohol (ever vs. never)23555315
rs6715.00E-26response to alcohol24277619
rs6711.00E-16alcohol consumption (maxi-drinks)24277619
rs6711.00E-16alcohol drinking24277619
rs6712.77E-09alcohol consumption23555315
rs6710.00000005alcohol dependence24277619

eQTL of rs671 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs671 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr12112192887112192956E067-48810
chr12112211077112211234E067-30532
chr12112211239112211372E067-30394
chr12112211459112214305E067-27461
chr12112214755112214834E067-26932
chr12112214875112215915E067-25851
chr12112226052112226466E067-15300
chr12112250781112251588E0679015
chr12112277752112277915E06735986
chr12112278075112278149E06736309
chr12112281800112281856E06740034
chr12112282228112282278E06740462
chr12112282350112282404E06740584
chr12112282773112282823E06741007
chr12112282990112283030E06741224
chr12112283223112283273E06741457
chr12112283296112283369E06741530
chr12112283860112284229E06742094
chr12112191808112191862E068-49904
chr12112191936112192017E068-49749
chr12112192094112192356E068-49410
chr12112192413112192846E068-48920
chr12112193493112193555E068-48211
chr12112193706112193829E068-47937
chr12112194124112194251E068-47515
chr12112194358112194424E068-47342
chr12112194468112194518E068-47248
chr12112194589112194676E068-47090
chr12112194787112194870E068-46896
chr12112194873112194955E068-46811
chr12112194958112196457E068-45309
chr12112196517112196597E068-45169
chr12112206883112207004E068-34762
chr12112207057112207139E068-34627
chr12112207231112207372E068-34394
chr12112211077112211234E068-30532
chr12112211239112211372E068-30394
chr12112211459112214305E068-27461
chr12112214755112214834E068-26932
chr12112250781112251588E0689015
chr12112281800112281856E06840034
chr12112282228112282278E06840462
chr12112282350112282404E06840584
chr12112282773112282823E06841007
chr12112282990112283030E06841224
chr12112191808112191862E069-49904
chr12112191936112192017E069-49749
chr12112192094112192356E069-49410
chr12112192413112192846E069-48920
chr12112194124112194251E069-47515
chr12112194358112194424E069-47342
chr12112194468112194518E069-47248
chr12112194589112194676E069-47090
chr12112194787112194870E069-46896
chr12112194873112194955E069-46811
chr12112194958112196457E069-45309
chr12112206883112207004E069-34762
chr12112211077112211234E069-30532
chr12112211239112211372E069-30394
chr12112211459112214305E069-27461
chr12112226052112226466E069-15300
chr12112250781112251588E0699015
chr12112277752112277915E06935986
chr12112278075112278149E06936309
chr12112282350112282404E06940584
chr12112282773112282823E06941007
chr12112282990112283030E06941224
chr12112194958112196457E070-45309
chr12112206883112207004E070-34762
chr12112256486112256526E07014720
chr12112257111112257217E07015345
chr12112257250112258148E07015484
chr12112258245112258347E07016479
chr12112277649112277701E07035883
chr12112277752112277915E07035986
chr12112281800112281856E07040034
chr12112282228112282278E07040462
chr12112282350112282404E07040584
chr12112282773112282823E07041007
chr12112191808112191862E071-49904
chr12112191936112192017E071-49749
chr12112192094112192356E071-49410
chr12112192413112192846E071-48920
chr12112192887112192956E071-48810
chr12112194958112196457E071-45309
chr12112196517112196597E071-45169
chr12112203436112203528E071-38238
chr12112203536112203790E071-37976
chr12112206883112207004E071-34762
chr12112211077112211234E071-30532
chr12112211239112211372E071-30394
chr12112211459112214305E071-27461
chr12112214755112214834E071-26932
chr12112226052112226466E071-15300
chr12112250781112251588E0719015
chr12112281800112281856E07140034
chr12112282228112282278E07140462
chr12112282350112282404E07140584
chr12112282773112282823E07141007
chr12112282990112283030E07141224
chr12112192094112192356E072-49410
chr12112192413112192846E072-48920
chr12112194468112194518E072-47248
chr12112194589112194676E072-47090
chr12112194787112194870E072-46896
chr12112194873112194955E072-46811
chr12112194958112196457E072-45309
chr12112206883112207004E072-34762
chr12112207057112207139E072-34627
chr12112211077112211234E072-30532
chr12112211239112211372E072-30394
chr12112211459112214305E072-27461
chr12112214755112214834E072-26932
chr12112226052112226466E072-15300
chr12112250781112251588E0729015
chr12112281800112281856E07240034
chr12112282228112282278E07240462
chr12112282350112282404E07240584
chr12112282773112282823E07241007
chr12112282990112283030E07241224
chr12112191808112191862E073-49904
chr12112191936112192017E073-49749
chr12112192094112192356E073-49410
chr12112192413112192846E073-48920
chr12112192887112192956E073-48810
chr12112194589112194676E073-47090
chr12112194787112194870E073-46896
chr12112194873112194955E073-46811
chr12112194958112196457E073-45309
chr12112206883112207004E073-34762
chr12112207057112207139E073-34627
chr12112207231112207372E073-34394
chr12112207485112207617E073-34149
chr12112207987112208189E073-33577
chr12112211077112211234E073-30532
chr12112211239112211372E073-30394
chr12112211459112214305E073-27461
chr12112214755112214834E073-26932
chr12112214875112215915E073-25851
chr12112244239112244304E0732473
chr12112250781112251588E0739015
chr12112277649112277701E07335883
chr12112277752112277915E07335986
chr12112278075112278149E07336309
chr12112282350112282404E07340584
chr12112282773112282823E07341007
chr12112191808112191862E074-49904
chr12112191936112192017E074-49749
chr12112192094112192356E074-49410
chr12112192413112192846E074-48920
chr12112194124112194251E074-47515
chr12112194358112194424E074-47342
chr12112194468112194518E074-47248
chr12112194589112194676E074-47090
chr12112194787112194870E074-46896
chr12112206883112207004E074-34762
chr12112207231112207372E074-34394
chr12112207485112207617E074-34149
chr12112207987112208189E074-33577
chr12112211077112211234E074-30532
chr12112211239112211372E074-30394
chr12112211459112214305E074-27461
chr12112214755112214834E074-26932
chr12112214875112215915E074-25851
chr12112225114112225224E074-16542
chr12112225257112225450E074-16316
chr12112250781112251588E0749015
chr12112281800112281856E07440034
chr12112282228112282278E07440462
chr12112282350112282404E07440584
chr12112282773112282823E07441007
chr12112282990112283030E07441224
chr12112283860112284229E07442094
chr12112191808112191862E081-49904
chr12112191936112192017E081-49749
chr12112192094112192356E081-49410
chr12112192413112192846E081-48920
chr12112192887112192956E081-48810
chr12112193192112193259E081-48507
chr12112193317112193367E081-48399
chr12112193493112193555E081-48211
chr12112193706112193829E081-47937
chr12112194124112194251E081-47515
chr12112194358112194424E081-47342
chr12112194468112194518E081-47248
chr12112194589112194676E081-47090
chr12112194787112194870E081-46896
chr12112194873112194955E081-46811
chr12112194958112196457E081-45309
chr12112196517112196597E081-45169
chr12112196660112196779E081-44987
chr12112277649112277701E08135883
chr12112277752112277915E08135986
chr12112278075112278149E08136309
chr12112281800112281856E08140034
chr12112282228112282278E08140462
chr12112282350112282404E08140584
chr12112282773112282823E08141007
chr12112192413112192846E082-48920
chr12112192887112192956E082-48810
chr12112194958112196457E082-45309
chr12112196517112196597E082-45169
chr12112272767112273138E08231001
chr12112277409112277512E08235643
chr12112281800112281856E08240034
chr12112282228112282278E08240462
chr12112282350112282404E08240584
chr12112282773112282823E08241007
chr12112282990112283030E08241224
chr12112283223112283273E08241457
chr12112283296112283369E08241530










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr12112204096112206016E067-35750
chr12112278853112281024E06737087
chr12112204096112206016E068-35750
chr12112278853112281024E06837087
chr12112204096112206016E069-35750
chr12112278853112281024E06937087
chr12112204096112206016E070-35750
chr12112278853112281024E07037087
chr12112204096112206016E071-35750
chr12112278853112281024E07137087
chr12112204096112206016E072-35750
chr12112278853112281024E07237087
chr12112204096112206016E073-35750
chr12112278853112281024E07337087
chr12112204096112206016E074-35750
chr12112278853112281024E07437087
chr12112204096112206016E081-35750
chr12112204096112206016E082-35750
chr12112278853112281024E08237087