rs6733455

Homo sapiens
C>T
None
Check p-value
SNV (Single Nucleotide Variation)
T=0315 (9436/29920,GnomAD)
T=0315 (9188/29116,TOPMED)
T=0319 (1597/5008,1000G)
T=0283 (1092/3854,ALSPAC)
T=0280 (1037/3708,TWINSUK)
chr2:42123347 (GRCh38.p7) (2p21)
AD
GWASdb2
1   publication(s)
See rs on genome
84 Enhancers around
10 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 2NC_000002.12:g.42123347C>T
GRCh37.p13 chr 2NC_000002.11:g.42350487C>T

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.582T=0.418
1000GenomesAmericanSub694C=0.780T=0.220
1000GenomesEast AsianSub1008C=0.788T=0.212
1000GenomesEuropeSub1006C=0.704T=0.296
1000GenomesGlobalStudy-wide5008C=0.681T=0.319
1000GenomesSouth AsianSub978C=0.620T=0.380
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.717T=0.283
The Genome Aggregation DatabaseAfricanSub8696C=0.613T=0.387
The Genome Aggregation DatabaseAmericanSub838C=0.750T=0.250
The Genome Aggregation DatabaseEast AsianSub1620C=0.766T=0.234
The Genome Aggregation DatabaseEuropeSub18464C=0.707T=0.292
The Genome Aggregation DatabaseGlobalStudy-wide29920C=0.684T=0.315
The Genome Aggregation DatabaseOtherSub302C=0.690T=0.310
Trans-Omics for Precision MedicineGlobalStudy-wide29116C=0.684T=0.315
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.720T=0.280
PMID Title Author Journal
21314694Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample.Kendler KSAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs67334550.000708alcohol dependence21314694

eQTL of rs6733455 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs6733455 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr24231351942314060E067-36427
chr24231421142314261E067-36226
chr24231427742314339E067-36148
chr24231481442314919E067-35568
chr24231500042315256E067-35231
chr24231892442319874E067-30613
chr24233781142338213E067-12274
chr24235930542361097E0678818
chr24236828342369863E06717796
chr24231351942314060E068-36427
chr24231876742318835E068-31652
chr24231892442319874E068-30613
chr24235527242355696E0684785
chr24235930542361097E0688818
chr24236828342369863E06817796
chr24236989142370293E06819404
chr24231351942314060E069-36427
chr24231421142314261E069-36226
chr24231427742314339E069-36148
chr24231500042315256E069-35231
chr24231876742318835E069-31652
chr24231892442319874E069-30613
chr24232300442323662E069-26825
chr24233781142338213E069-12274
chr24235527242355696E0694785
chr24235930542361097E0698818
chr24237029842370379E07019811
chr24231351942314060E071-36427
chr24231421142314261E071-36226
chr24231427742314339E071-36148
chr24231481442314919E071-35568
chr24231500042315256E071-35231
chr24232402942324647E071-25840
chr24232479042324869E071-25618
chr24232487942324929E071-25558
chr24232497942325076E071-25411
chr24232723342327293E071-23194
chr24232738442327492E071-22995
chr24232751942327625E071-22862
chr24232764442327860E071-22627
chr24233057842330701E071-19786
chr24233781142338213E071-12274
chr24234460842344716E071-5771
chr24234508842345846E071-4641
chr24235930542361097E0718818
chr24236375842363837E07113271
chr24236405842364114E07113571
chr24236412242364182E07113635
chr24236828342369863E07117796
chr24236989142370293E07119404
chr24237456842375530E07124081
chr24231351942314060E072-36427
chr24231421142314261E072-36226
chr24231427742314339E072-36148
chr24231481442314919E072-35568
chr24231500042315256E072-35231
chr24231892442319874E072-30613
chr24232300442323662E072-26825
chr24233781142338213E072-12274
chr24235930542361097E0728818
chr24231351942314060E073-36427
chr24231421142314261E073-36226
chr24231427742314339E073-36148
chr24231892442319874E073-30613
chr24234508842345846E073-4641
chr24234598242346058E073-4429
chr24235527242355696E0734785
chr24235930542361097E0738818
chr24236828342369863E07317796
chr24231351942314060E074-36427
chr24231421142314261E074-36226
chr24231427742314339E074-36148
chr24231892442319874E074-30613
chr24233753342337768E074-12719
chr24233781142338213E074-12274
chr24236828342369863E07417796
chr24236989142370293E07419404
chr24233753342337768E081-12719
chr24233781142338213E081-12274
chr24235930542361097E0818818
chr24236828342369863E08117796
chr24239065842390938E08140171
chr24235527242355696E0824785
chr24239940742399479E08248920










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr24239575842397630E06745271
chr24239575842397630E06845271
chr24239575842397630E06945271
chr24239575842397630E07045271
chr24239575842397630E07145271
chr24239575842397630E07245271
chr24239575842397630E07345271
chr24239575842397630E07445271
chr24239575842397630E08145271
chr24239575842397630E08245271