rs6743661

Homo sapiens
T>G
TTC27 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
G=0174 (5179/29760,GnomAD)
G=0152 (4434/29116,TOPMED)
G=0234 (1171/5008,1000G)
G=0221 (850/3854,ALSPAC)
G=0216 (800/3708,TWINSUK)
chr2:32708028 (GRCh38.p7) (2p22.3)
AD
GWASdb2
1   publication(s)
See rs on genome
44 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 2NC_000002.12:g.32708028T>G
GRCh37.p13 chr 2NC_000002.11:g.32933095T>G

Gene: TTC27, tetratricopeptide repeat domain 27(plus strand)

Molecule type Change Amino acid[Codon] SO Term
TTC27 transcript variant 2NM_001193509.1:c.N/AIntron Variant
TTC27 transcript variant 1NM_017735.4:c.N/AIntron Variant
TTC27 transcript variant X2XM_005264416.1:c.N/AIntron Variant
TTC27 transcript variant X1XM_011532958.1:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.970G=0.030
1000GenomesAmericanSub694T=0.810G=0.190
1000GenomesEast AsianSub1008T=0.662G=0.338
1000GenomesEuropeSub1006T=0.774G=0.226
1000GenomesGlobalStudy-wide5008T=0.766G=0.234
1000GenomesSouth AsianSub978T=0.560G=0.440
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.779G=0.221
The Genome Aggregation DatabaseAfricanSub8678T=0.936G=0.064
The Genome Aggregation DatabaseAmericanSub824T=0.750G=0.250
The Genome Aggregation DatabaseEast AsianSub1612T=0.639G=0.361
The Genome Aggregation DatabaseEuropeSub18344T=0.794G=0.205
The Genome Aggregation DatabaseGlobalStudy-wide29760T=0.826G=0.174
The Genome Aggregation DatabaseOtherSub302T=0.760G=0.240
Trans-Omics for Precision MedicineGlobalStudy-wide29116T=0.847G=0.152
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.784G=0.216
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs67436610.00011alcohol dependence20201924

eQTL of rs6743661 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs6743661 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr23293623232936608E0673137
chr23293665432936704E0673559
chr23293705032937172E0673955
chr23293719232937325E0674097
chr23296024632960438E06727151
chr23293623232936608E0693137
chr23293783232937905E0694737
chr23297712032977378E06944025
chr23297741232977537E06944317
chr23297787632977952E06944781
chr23297796532978338E06944870
chr23296388532964023E07030790
chr23296419332964291E07031098
chr23296449832964622E07031403
chr23296484932965306E07031754
chr23293623232936608E0713137
chr23293665432936704E0713559
chr23293705032937172E0713955
chr23293719232937325E0714097
chr23293768232937732E0714587
chr23293775632937822E0714661
chr23293783232937905E0714737
chr23293803432938215E0714939
chr23294049532940661E0717400
chr23297712032977378E07144025
chr23297741232977537E07144317
chr23297787632977952E07144781
chr23297796532978338E07144870
chr23297712032977378E07244025
chr23297741232977537E07244317
chr23297787632977952E07244781
chr23297796532978338E07244870
chr23292739232927640E073-5455
chr23289734832897576E074-35519
chr23292739232927640E074-5455
chr23293623232936608E0743137
chr23293665432936704E0743559
chr23293705032937172E0743955
chr23293719232937325E0744097
chr23297741232977537E07444317
chr23294094232941090E0817847
chr23294118032941343E0818085
chr23296449832964622E08231403
chr23296484932965306E08231754