rs6754001

Homo sapiens
A>G
None
Check p-value
SNV (Single Nucleotide Variation)
G=0251 (7525/29952,GnomAD)
G=0243 (7089/29116,TOPMED)
G=0308 (1541/5008,1000G)
G=0182 (702/3854,ALSPAC)
G=0182 (674/3708,TWINSUK)
chr2:111670832 (GRCh38.p7) (2q13)
ND
GWASdb2
1   publication(s)
See rs on genome
30 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 2NC_000002.12:g.111670832A>G
GRCh37.p13 chr 2NC_000002.11:g.112428409A>G

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.685G=0.315
1000GenomesAmericanSub694A=0.670G=0.330
1000GenomesEast AsianSub1008A=0.576G=0.424
1000GenomesEuropeSub1006A=0.825G=0.175
1000GenomesGlobalStudy-wide5008A=0.692G=0.308
1000GenomesSouth AsianSub978A=0.700G=0.300
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.818G=0.182
The Genome Aggregation DatabaseAfricanSub8708A=0.696G=0.304
The Genome Aggregation DatabaseAmericanSub838A=0.660G=0.340
The Genome Aggregation DatabaseEast AsianSub1618A=0.547G=0.453
The Genome Aggregation DatabaseEuropeSub18486A=0.793G=0.206
The Genome Aggregation DatabaseGlobalStudy-wide29952A=0.748G=0.251
The Genome Aggregation DatabaseOtherSub302A=0.880G=0.120
Trans-Omics for Precision MedicineGlobalStudy-wide29116A=0.756G=0.243
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.818G=0.182
PMID Title Author Journal
22377092ANAPC1 and SLCO3A1 are associated with nicotine dependence: meta-analysis of genome-wide association studies.Wang KSDrug Alcohol Depend

P-Value

SNP ID p-value Traits Study
rs67540011.52E-05nicotine dependence (smoking)22377092

eQTL of rs6754001 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs6754001 in Fetal Brain

Probe ID Position Gene beta p-value
cg23262488chr2:112468472-0.03981815111571357.3123e-9

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr2112462901112464321E07034492
chr2112464516112464643E07036107
chr2112433581112433731E0725172
chr2112419497112419604E081-8805
chr2112419728112420435E081-7974
chr2112420457112420513E081-7896
chr2112420740112420891E081-7518
chr2112433352112433490E0814943
chr2112433581112433731E0815172
chr2112434054112434302E0815645
chr2112434448112434529E0816039
chr2112435017112435057E0816608
chr2112435151112435211E0816742
chr2112435485112435572E0817076
chr2112435883112436108E0817474
chr2112436209112436591E0817800
chr2112436641112436704E0818232
chr2112436753112437061E0818344
chr2112449091112449472E08120682
chr2112449553112449603E08121144
chr2112449709112449759E08121300
chr2112449868112450073E08121459
chr2112456326112457104E08127917
chr2112462901112464321E08134492
chr2112465304112465370E08136895
chr2112466166112466234E08137757
chr2112466329112466623E08137920
chr2112436209112436591E0827800
chr2112456326112457104E08227917
chr2112462901112464321E08234492