rs6770678

Homo sapiens
C>T
FAM19A4 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
C==0325 (9726/29904,GnomAD)
C==0260 (7597/29118,TOPMED)
C==0402 (2013/5008,1000G)
C==0328 (1264/3854,ALSPAC)
C==0318 (1180/3708,TWINSUK)
chr3:68911859 (GRCh38.p7) (3p14.1)
AD
GWASdb2
1   publication(s)
See rs on genome
9 Enhancers around
30 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 3NC_000003.12:g.68911859C>T
GRCh37.p13 chr 3NC_000003.11:g.68961010C>T

Gene: FAM19A4, family with sequence similarity 19 (chemokine (C-C motif)-like), member A4(minus strand)

Molecule type Change Amino acid[Codon] SO Term
FAM19A4 transcript variant 2NM_001005527.2:c.N/AIntron Variant
FAM19A4 transcript variant 1NM_182522.4:c.N/AIntron Variant
FAM19A4 transcript variant X1XM_011533371.1:c.N/AIntron Variant
FAM19A4 transcript variant X2XM_011533372.1:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.123T=0.877
1000GenomesAmericanSub694C=0.520T=0.480
1000GenomesEast AsianSub1008C=0.662T=0.338
1000GenomesEuropeSub1006C=0.308T=0.692
1000GenomesGlobalStudy-wide5008C=0.402T=0.598
1000GenomesSouth AsianSub978C=0.530T=0.470
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.328T=0.672
The Genome Aggregation DatabaseAfricanSub8718C=0.164T=0.836
The Genome Aggregation DatabaseAmericanSub838C=0.540T=0.460
The Genome Aggregation DatabaseEast AsianSub1604C=0.638T=0.362
The Genome Aggregation DatabaseEuropeSub18442C=0.365T=0.634
The Genome Aggregation DatabaseGlobalStudy-wide29904C=0.325T=0.674
The Genome Aggregation DatabaseOtherSub302C=0.260T=0.740
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.260T=0.739
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.318T=0.682
PMID Title Author Journal
21314694Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample.Kendler KSAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs67706780.000529alcohol dependence21314694

eQTL of rs6770678 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs6770678 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr36900309469003435E06942084
chr36900353969003707E06942529
chr36893148468931643E070-29367
chr36896266868962722E0701658
chr36900309469003435E07142084
chr36900353969003707E07142529
chr36900309469003435E07242084
chr36900309469003435E07442084
chr36900353969003707E07442529





Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr36898064568980730E06719635
chr36898078068980898E06719770
chr36898095568981322E06719945
chr36898137968982140E06720369
chr36898064568980730E06819635
chr36898078068980898E06819770
chr36898095568981322E06819945
chr36898137968982140E06820369
chr36898064568980730E06919635
chr36898078068980898E06919770
chr36898095568981322E06919945
chr36898137968982140E06920369
chr36898064568980730E07119635
chr36898078068980898E07119770
chr36898095568981322E07119945
chr36898137968982140E07120369
chr36898064568980730E07219635
chr36898078068980898E07219770
chr36898095568981322E07219945
chr36898137968982140E07220369
chr36898078068980898E07319770
chr36898095568981322E07319945
chr36898137968982140E07320369
chr36898064568980730E07419635
chr36898078068980898E07419770
chr36898095568981322E07419945
chr36898137968982140E07420369
chr36898078068980898E08219770
chr36898095568981322E08219945
chr36898137968982140E08220369