rs6818704

Homo sapiens
A>G
None
Check p-value
SNV (Single Nucleotide Variation)
G=0189 (5682/29928,GnomAD)
G=0236 (6886/29118,TOPMED)
G=0171 (854/5008,1000G)
G=0152 (584/3854,ALSPAC)
G=0149 (554/3708,TWINSUK)
chr4:185125319 (GRCh38.p7) (4q35.1)
AD
GWASdb2
1   publication(s)
See rs on genome
48 Enhancers around
26 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 4NC_000004.12:g.185125319A>G
GRCh37.p13 chr 4NC_000004.11:g.186046473A>G

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.598G=0.402
1000GenomesAmericanSub694A=0.890G=0.110
1000GenomesEast AsianSub1008A=0.996G=0.004
1000GenomesEuropeSub1006A=0.867G=0.133
1000GenomesGlobalStudy-wide5008A=0.829G=0.171
1000GenomesSouth AsianSub978A=0.890G=0.110
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.848G=0.152
The Genome Aggregation DatabaseAfricanSub8700A=0.636G=0.364
The Genome Aggregation DatabaseAmericanSub838A=0.920G=0.080
The Genome Aggregation DatabaseEast AsianSub1606A=0.994G=0.006
The Genome Aggregation DatabaseEuropeSub18482A=0.869G=0.130
The Genome Aggregation DatabaseGlobalStudy-wide29928A=0.810G=0.189
The Genome Aggregation DatabaseOtherSub302A=0.910G=0.090
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.763G=0.236
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.851G=0.149
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs68187040.0000466alcoholismpha002891
rs68187040.0000466alcohol dependence20201924

eQTL of rs6818704 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs6818704 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr4186067116186067225E06720643
chr4186067549186067664E06721076
chr4186067680186067833E06721207
chr4186092669186092786E06746196
chr4186092943186093097E06746470
chr4186067116186067225E06820643
chr4186067549186067664E06821076
chr4186092943186093097E06846470
chr4186093587186093726E06847114
chr4186000396186000517E069-45956
chr4186000619186001119E069-45354
chr4186055442186055988E0698969
chr4186055999186056055E0699526
chr4186066113186066429E06919640
chr4186067116186067225E06920643
chr4186067549186067664E06921076
chr4186067680186067833E06921207
chr4186092943186093097E06946470
chr4186093587186093726E06947114
chr4186066894186067065E07020421
chr4186093587186093726E07047114
chr4186000396186000517E071-45956
chr4186066894186067065E07120421
chr4186087298186087377E07140825
chr4186092669186092786E07146196
chr4186092943186093097E07146470
chr4186000396186000517E072-45956
chr4186000619186001119E072-45354
chr4186087298186087377E07240825
chr4186092943186093097E07246470
chr4186093587186093726E07247114
chr4186094046186094258E07247573
chr4186067116186067225E07320643
chr4186067549186067664E07321076
chr4186067680186067833E07321207
chr4186066113186066429E07419640
chr4186066894186067065E07420421
chr4186067116186067225E07420643
chr4186067549186067664E07421076
chr4186067680186067833E07421207
chr4186092669186092786E07446196
chr4186092943186093097E07446470
chr4186093587186093726E07447114
chr4186044966186045016E081-1457
chr4186066113186066429E08119640
chr4186066894186067065E08120421
chr4186066113186066429E08219640
chr4186093587186093726E08247114










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr4186048213186049252E0671740
chr4186049393186050471E0672920
chr4186063565186065181E06717092
chr4186048213186049252E0681740
chr4186049393186050471E0682920
chr4186063565186065181E06817092
chr4186048213186049252E0691740
chr4186049393186050471E0692920
chr4186063565186065181E06917092
chr4186063565186065181E07017092
chr4186048213186049252E0711740
chr4186049393186050471E0712920
chr4186063565186065181E07117092
chr4186048213186049252E0721740
chr4186049393186050471E0722920
chr4186063565186065181E07217092
chr4186048213186049252E0731740
chr4186049393186050471E0732920
chr4186063565186065181E07317092
chr4186048213186049252E0741740
chr4186049393186050471E0742920
chr4186063565186065181E07417092
chr4186063565186065181E08117092
chr4186048213186049252E0821740
chr4186049393186050471E0822920
chr4186063565186065181E08217092