rs6827035

Homo sapiens
G>A / G>C
None
Check p-value
SNV (Single Nucleotide Variation)
G==0480 (14307/29798,GnomAD)
G==0453 (13194/29118,TOPMED)
G==0474 (2374/5008,1000G)
C=0496 (1911/3854,ALSPAC)
G==0494 (1831/3708,TWINSUK)
chr4:35473477 (GRCh38.p7) (4p15.1)
ND
GWASdb2
1   publication(s)
See rs on genome
3 Enhancers around
14 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 4NC_000004.12:g.35473477G>A
GRCh38.p7 chr 4NC_000004.12:g.35473477G>C
GRCh37.p13 chr 4NC_000004.11:g.35475099G>A
GRCh37.p13 chr 4NC_000004.11:g.35475099G>C

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.380C=0.620
1000GenomesAmericanSub694G=0.450C=0.550
1000GenomesEast AsianSub1008G=0.643C=0.357
1000GenomesEuropeSub1006G=0.533C=0.467
1000GenomesGlobalStudy-wide5008G=0.474C=0.526
1000GenomesSouth AsianSub978G=0.390C=0.610
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.504C=0.496
The Genome Aggregation DatabaseAfricanSub8696G=0.400A=0.000
The Genome Aggregation DatabaseAmericanSub826G=0.430A=0.00,
The Genome Aggregation DatabaseEast AsianSub1608G=0.672A=0.000
The Genome Aggregation DatabaseEuropeSub18366G=0.502A=0.000
The Genome Aggregation DatabaseGlobalStudy-wide29798G=0.480A=0.000
The Genome Aggregation DatabaseOtherSub302G=0.580A=0.00,
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.453C=0.546
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.494C=0.506
PMID Title Author Journal
17158188Novel genes identified in a high-density genome wide association study for nicotine dependence.Bierut LJHum Mol Genet

P-Value

SNP ID p-value Traits Study
rs68270350.000288nicotine dependence17158188

eQTL of rs6827035 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs6827035 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr43552673735526787E0749581
chr43553670135536912E08219545
chr43553699835537160E08219842


Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr43552687235526986E0689716
chr43552703435527236E0689878
chr43552753335527608E06810377
chr43552687235526986E0699716
chr43552703435527236E0699878
chr43552687235526986E0719716
chr43552703435527236E0719878
chr43552753335527608E07110377
chr43552687235526986E0729716
chr43552703435527236E0729878
chr43552687235526986E0739716
chr43552703435527236E0739878
chr43552687235526986E0749716
chr43552703435527236E0749878