rs6874566

Homo sapiens
T>C
LINC01331 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
C=0341 (10208/29922,GnomAD)
C=0361 (10519/29118,TOPMED)
C=0351 (1760/5008,1000G)
C=0270 (1039/3854,ALSPAC)
C=0259 (961/3708,TWINSUK)
chr5:74491055 (GRCh38.p7) (5q13.3)
AD
GWASdb2
1   publication(s)
See rs on genome
64 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 5NC_000005.10:g.74491055T>C
GRCh37.p13 chr 5NC_000005.9:g.73786880T>C

Gene: LINC01331, long intergenic non-protein coding RNA 1331(minus strand)

Molecule type Change Amino acid[Codon] SO Term
LINC01331 transcriptNR_126354.1:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.515C=0.485
1000GenomesAmericanSub694T=0.640C=0.360
1000GenomesEast AsianSub1008T=0.753C=0.247
1000GenomesEuropeSub1006T=0.728C=0.272
1000GenomesGlobalStudy-wide5008T=0.649C=0.351
1000GenomesSouth AsianSub978T=0.650C=0.350
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.730C=0.270
The Genome Aggregation DatabaseAfricanSub8706T=0.541C=0.459
The Genome Aggregation DatabaseAmericanSub834T=0.700C=0.300
The Genome Aggregation DatabaseEast AsianSub1618T=0.784C=0.216
The Genome Aggregation DatabaseEuropeSub18462T=0.701C=0.298
The Genome Aggregation DatabaseGlobalStudy-wide29922T=0.658C=0.341
The Genome Aggregation DatabaseOtherSub302T=0.700C=0.300
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.638C=0.361
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.741C=0.259
PMID Title Author Journal
24277619ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.Quillen EEAm J Med Genet B Neuropsychiatr Genet

P-Value

SNP ID p-value Traits Study
rs68745660.000874alcohol dependence24277619

eQTL of rs6874566 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs6874566 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr57377837273778641E067-8239
chr57377895073779144E067-7736
chr57383369673833919E06846816
chr57383400573834512E06847125
chr57375671373756794E070-30086
chr57375702373757063E070-29817
chr57375713073757622E070-29258
chr57375800273758057E070-28823
chr57375828573758478E070-28402
chr57376383973763927E070-22953
chr57376469373764787E070-22093
chr57376489873764954E070-21926
chr57376545873765636E070-21244
chr57376567873765821E070-21059
chr57376626473766324E070-20556
chr57376638773766644E070-20236
chr57377232073772635E070-14245
chr57377266873772718E070-14162
chr57377298973773066E070-13814
chr57377837273778641E070-8239
chr57378781973787892E070939
chr57378793373788617E0701053
chr57379504373795432E0708163
chr57379546273795777E0708582
chr57379591373796384E0709033
chr57379643873796677E0709558
chr57380320573803521E07016325
chr57380359873803698E07016718
chr57380373473804406E07016854
chr57383184773832120E07044967
chr57383219573832245E07045315
chr57383236173832528E07045481
chr57377837273778641E071-8239
chr57377837273778641E072-8239
chr57377895073779144E072-7736
chr57379546273795777E0728582
chr57379591373796384E0729033
chr57381820573818396E07231325
chr57381321473813391E07326334
chr57381408373814167E07327203
chr57377895073779144E074-7736
chr57375702373757063E081-29817
chr57376545873765636E081-21244
chr57376567873765821E081-21059
chr57376626473766324E081-20556
chr57376638773766644E081-20236
chr57377195173772222E081-14658
chr57377232073772635E081-14245
chr57377266873772718E081-14162
chr57377298973773066E081-13814
chr57379546273795777E0818582
chr57379591373796384E0819033
chr57379643873796677E0819558
chr57375671373756794E082-30086
chr57375702373757063E082-29817
chr57375713073757622E082-29258
chr57375800273758057E082-28823
chr57376545873765636E082-21244
chr57376567873765821E082-21059
chr57377195173772222E082-14658
chr57377232073772635E082-14245
chr57377266873772718E082-14162
chr57377298973773066E082-13814
chr57377837273778641E082-8239